Alpha-taxilin

TXLNA
Identifiers
Aliases	TXLNA , IL14, TXLN, IL-14, taxilin alpha
External IDs	OMIM: 608676 MGI: 105968 HomoloGene: 14062 GeneCards: TXLNA
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p35.2 Start 32,179,675 bp [1] End 32,198,285 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4 D2.2|4 63.26 cM Start 129,519,871 bp [2] End 129,534,858 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium Right adrenal gland Left adrenal gland right coronary artery left uterine tube anterior pituitary right lobe of liver islet of Langerhans ascending aorta right lobe of thyroid gland Top expressed in hand lip maxillary prominence foot otolith organ yolk sac utricle thymus neural tube calvaria More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytokine activity syntaxin binding protein binding high molecular weight B cell growth factor receptor binding Cellular component cytoplasm membrane extracellular region cytosol Biological process B cell activation cell population proliferation exocytosis regulation of signaling receptor activity cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 200081 109658 Ensembl ENSG00000084652 ENSMUSG00000053841 UniProt P40222 Q6PAM1 RefSeq (mRNA) NM_175852 NM_001376857 NM_001376858 NM_001376859 NM_001005506 NM_001199695 RefSeq (protein) NP_787048 NP_001363786 NP_001363787 NP_001363788 NP_001005506 NP_001186624 Location (UCSC) Chr 1: 32.18 – 32.2 Mb Chr 4: 129.52 – 129.53 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Alpha-taxilin also known as interleukin-14 (IL-14) or high molecular weight B-cell growth factor (HMW-BCGF) is a protein that in humans is encoded by the TXLNA gene. ^{[5] [6] [7]}

Interleukin-14 is a cytokine that controls the growth and proliferation of both normal and cancerous B cells. ^[8] This molecule was also recently designated taxilin. ^[9] IL-14 induces B-cell proliferation, inhibits antibody secretion, and expands selected B-cell subgroups. This interleukin is produced mainly by T cells and certain malignant B cells.

Gene

In murine models, two distinct transcripts are produced from opposite strands of the il14 gene that are called IL-14α and IL-14β. ^[10] The il14 locus is near the gene for LCK on chromosome 1 in humans.

References

1. GRCh38: Ensembl release 89: ENSG00000084652 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000053841 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nogami S, Satoh S, Tanaka-Nakadate S, Yoshida K, Nakano M, Terano A, Shirataki H (Jun 2004). "Identification and characterization of taxilin isoforms". Biochem. Biophys. Res. Commun. 319 (3): 936–43. doi:10.1016/j.bbrc.2004.05.073. PMID   15184072.
6. Nogami S, Satoh S, Nakano M, Terano A, Shirataki H (Nov 2003). "Interaction of taxilin with syntaxin which does not form the SNARE complex". Biochem. Biophys. Res. Commun. 311 (4): 797–802. doi:10.1016/j.bbrc.2003.10.069. PMID   14623251.
7. "Entrez Gene: TXLNA taxilin alpha".
8. Ambrus JL, Pippin J, Joseph A, Xu C, Blumenthal D, Tamayo A, Claypool K, McCourt D, Srikiatchatochorn A, Ford RJ (July 1993). "Identification of a cDNA for a human high-molecular-weight B-cell growth factor". Proc. Natl. Acad. Sci. U.S.A. 90 (13): 6330–4. Bibcode:1993PNAS...90.6330A. doi: 10.1073/pnas.90.13.6330 . PMC   46922 . PMID   8327514.
9. Nogami S, Satoh S, Nakano M, Shimizu H, Fukushima H, Maruyama A, Terano A, Shirataki H (January 2003). "Taxilin; a novel syntaxin-binding protein that is involved in Ca2+-dependent exocytosis in neuroendocrine cells". Genes Cells. 8 (1): 17–28. doi: 10.1046/j.1365-2443.2003.00612.x . PMID   12558796.
10. Shen L, Zhang C, Wang T, Brooks S, Ford RJ, Lin-Lee YC, Kasianowicz A, Kumar V, Martin L, Liang P, Cowell J, Ambrus JL (October 2006). "Development of autoimmunity in IL-14alpha-transgenic mice". J. Immunol. 177 (8): 5676–86. doi: 10.4049/jimmunol.177.8.5676 . PMID   17015757. S2CID   86324456.

External links

• Human TXLNA genome location and TXLNA gene details page in the UCSC Genome Browser .

Further reading

• Ambrus JL, Pippin J, Joseph A, et al. (1993). "Identification of a cDNA for a human high-molecular-weight B-cell growth factor". Proc. Natl. Acad. Sci. U.S.A. 90 (13): 6330–4. Bibcode:1993PNAS...90.6330A. doi: 10.1073/pnas.90.13.6330 . PMC   46922 . PMID   8327514.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
• Ambrus JL, Pippin J, Joseph A, et al. (1996). "Identification of a cDNA for a human high molecular-weight B-cell growth factor". Proc. Natl. Acad. Sci. U.S.A. 93 (15): 8154. PMC   38894 . PMID   8755619.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Nogami S, Satoh S, Nakano M, et al. (2003). "Taxilin; a novel syntaxin-binding protein that is involved in Ca2+-dependent exocytosis in neuroendocrine cells". Genes Cells. 8 (1): 17–28. doi: 10.1046/j.1365-2443.2003.00612.x . PMID   12558796.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID   14743216. S2CID   11683986.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.
• Shen L, Zhang C, Wang T, et al. (2007). "Development of autoimmunity in IL-14alpha-transgenic mice". J. Immunol. 177 (8): 5676–86. doi: 10.4049/jimmunol.177.8.5676 . PMID   17015757. S2CID   86324456.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.