IFNA14

IFNA14
Identifiers
Aliases	IFNA14 , IFN-alphaH, LEIF2H, interferon alpha 14
External IDs	OMIM: 147579 HomoloGene: 122139 GeneCards: IFNA14
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9p21.3 Start 21,239,002 bp [1] End 21,240,005 bp [1]
Gene ontology Molecular function • cytokine activity • type I interferon receptor binding • cytokine receptor binding Cellular component • extracellular region • extracellular space Biological process • natural killer cell activation involved in immune response • B cell differentiation • defense response • B cell proliferation • blood coagulation • positive regulation of peptidyl-serine phosphorylation of STAT protein • humoral immune response • adaptive immune response • defense response to virus • type I interferon signaling pathway • response to exogenous dsRNA • T cell activation involved in immune response • innate immune response • cytokine-mediated signaling pathway • regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3448	n/a
Ensembl	ENSG00000228083	n/a
UniProt	P01570	n/a
RefSeq (mRNA)	NM_002172	n/a
RefSeq (protein)	NP_002163	n/a
Location (UCSC)	Chr 9: 21.24 – 21.24 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

Interferon alpha-14 is a protein that in humans is encoded by the IFNA14 gene. ^{[3] [4]}

References

1. GRCh38: Ensembl release 89: ENSG00000228083 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM, Diaz MO (Dec 1992). "Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia". Genomics. 14 (2): 437–43. doi:10.1016/S0888-7543(05)80238-1. PMID   1385305.
4. "Entrez Gene: IFNA14 interferon, alpha 14".

Further reading

• Sen GC, Lengyel P (1992). "The interferon system. A bird's eye view of its biochemistry". J. Biol. Chem. 267 (8): 5017–20. doi: 10.1016/S0021-9258(18)42719-6 . PMID   1371992.
• Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID   1602151.
• Henco K, Brosius J, Fujisawa A, et al. (1985). "Structural relationship of human interferon alpha genes and pseudogenes". J. Mol. Biol. 185 (2): 227–60. doi:10.1016/0022-2836(85)90401-2. PMID   4057246.
• Goeddel DV, Leung DW, Dull TJ, et al. (1981). "The structure of eight distinct cloned human leukocyte interferon cDNAs". Nature. 290 (5801): 20–6. Bibcode:1981Natur.290...20G. doi:10.1038/290020a0. PMID   6163083. S2CID   1900300.
• Lawn RM, Adelman J, Dull TJ, et al. (1981). "DNA sequence of two closely linked human leukocyte interferon genes". Science. 212 (4499): 1159–62. Bibcode:1981Sci...212.1159L. doi:10.1126/science.6165082. PMID   6165082.
• Tiefenbrun N, Melamed D, Levy N, et al. (1996). "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest". Mol. Cell. Biol. 16 (7): 3934–44. doi:10.1128/MCB.16.7.3934. PMC   231390 . PMID   8668211.
• Hussain M, Gill DS, Liao MJ (1997). "Identification of interferon-alpha 7, -alpha 14, and -alpha 21 variants in the genome of a large human population". J. Interferon Cytokine Res. 16 (10): 853–9. doi:10.1089/jir.1996.16.853. PMID   8910771.
• Nyman TA, Tölö H, Parkkinen J, Kalkkinen N (1998). "Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes". Biochem. J. 329 (Pt 2): 295–302. doi:10.1042/bj3290295. PMC   1219044 . PMID   9425112.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.