IFNB1

IFNB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1AU1
Identifiers
Aliases	IFNB1 , IFB, IFF, IFNB, IFN-beta, interferon beta 1
External IDs	OMIM: 147640 MGI: 107657 HomoloGene: 1640 GeneCards: IFNB1
Gene location (Human)
Chr.	Chromosome 9 (human)
End	21,077,942 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	88,441,011 bp
RNA expression pattern
	Top expressed in
	bone; ; bone marrow; ; islet of Langerhans; ; upper lobe of lung; ; upper lobe of left lung; ; left lobe of thyroid gland;
	Top expressed in
	sternocleidomastoid muscle; ; triceps brachii muscle; ; temporal muscle; ; digastric muscle; ; artery; ; skin of abdomen; ; carotid body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytokine activity ; cytokine receptor binding ; chloramphenicol O-acetyltransferase activity ; type I interferon receptor binding ;
Cellular component	extracellular space ; extracellular region ;
Biological process	positive regulation of peptidyl-serine phosphorylation of STAT protein ; blood coagulation ; B cell differentiation ; cellular response to interferon-beta ; regulation of MHC class I biosynthetic process ; negative regulation of viral genome replication ; natural killer cell activation ; B cell activation involved in immune response ; positive regulation of apoptotic signaling pathway ; cell surface receptor signaling pathway ; natural killer cell activation involved in immune response ; response to exogenous dsRNA ; response to virus ; T cell activation involved in immune response ; positive regulation of transcription by RNA polymerase II ; defense response ; negative regulation of T cell differentiation ; positive regulation of innate immune response ; cellular response to exogenous dsRNA ; negative regulation of T-helper 2 cell cytokine production ; defense response to virus ; type I interferon signaling pathway ; regulation of signaling receptor activity ; humoral immune response ; B cell proliferation ; adaptive immune response ; cytokine-mediated signaling pathway ;
	Sources:Amigo / QuickGO
Orthologs
	3456
	15977
	ENSG00000171855
	ENSMUSG00000048806
	P01574
	P01575
	NM_002176
	NM_010510
	NP_002167
	NP_034640
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated May 18, 2024

Interferon beta is a protein that in humans is encoded by the IFNB1 gene.^[5] The natural and recombinant protein forms have antiviral, antibacterial, and anticancer properties.

Interferon beta 1a (tradenames: Avonex and Rebif) and Interferon beta 1b (tradenames: Betaseron/Betaferon) are used as drugs.

Related Research Articles

Interferons are a group of signaling proteins made and released by host cells in response to the presence of several viruses. In a typical scenario, a virus-infected cell will release interferons causing nearby cells to heighten their anti-viral defenses.

Chemokine ligands 4 previously known as macrophage inflammatory protein (MIP-1β), is a protein which in humans is encoded by the CCL4 gene. CCL4 belongs to a cluster of genes located on 17q11-q21 of the chromosomal region. Identification and localization of the gene on the chromosome 17 was in 1990 although the discovery of MIP-1 was initiated in 1988 with the purification of a protein doublet corresponding to inflammatory activity from supernatant of endotoxin-stimulated murine macrophages. At that time, it was also named as "macrophage inflammatory protein-1" (MIP-1) due to its inflammatory properties.

Signal transducer and activator of transcription 2 is a protein that in humans is encoded by the STAT2 gene. It is a member of the STAT protein family. This protein is critical to the biological response of type I interferons (IFNs). It functions as a transcription factor downstream of type I interferons. STAT2 sequence identity between mouse and human is only 68%.

Interferon-stimulated gene 15 (ISG15) is a 17 kDA secreted protein that in humans is encoded by the ISG15 gene. ISG15 is induced by type I interferon (IFN) and serves many functions, acting both as an extracellular cytokine and an intracellular protein modifier. The precise functions are diverse and vary among species but include potentiation of Interferon gamma (IFN-II) production in lymphocytes, ubiquitin-like conjugation to newly-synthesized proteins and negative regulation of the IFN-I response.

Interferon regulatory factor 2 is a protein that in humans is encoded by the IRF2 gene.

Interferon alpha-1 is a protein that in humans is encoded by the IFNA1 gene.

Sodium/potassium-transporting ATPase subunit beta-1 is an enzyme that in humans is encoded by the ATP1B1 gene.

Ski-like protein is a protein that in humans is encoded by the SKIL gene.

Interferon alpha-inducible protein 27 is a protein that in humans is encoded by the IFI27 gene.

MDA5 is a RIG-I-like receptor dsRNA helicase enzyme that is encoded by the IFIH1 gene in humans. MDA5 is part of the RIG-I-like receptor (RLR) family, which also includes RIG-I and LGP2, and functions as a pattern recognition receptor capable of detecting viruses. It is generally believed that MDA5 recognizes double stranded RNA (dsRNA) over 2000nts in length, however it has been shown that whilst MDA5 can detect and bind to cytoplasmic dsRNA, it is also activated by a high molecular weight RNA complex composed of ssRNA and dsRNA. For many viruses, effective MDA5-mediated antiviral responses are dependent on functionally active LGP2. The signaling cascades in MDA5 is initiated via CARD domain. Some observations made in cancer cells show that MDA5 also interacts with cellular RNA is able to induce an autoinflammatory response.

Interferon alpha-inducible protein 6 is a protein that in humans is encoded by the IFI6 gene.

Interferon alpha-7 is a protein that in humans is encoded by the IFNA7 gene.

Interferon omega-1 is a protein that in humans is encoded by the IFNW1 gene.

Interferon alpha-8 is a protein that in humans is encoded by the IFNA8 gene.

Interferon alpha-10 is a protein that in humans is encoded by the IFNA10 gene.

Interferon alpha-5 is a protein that in humans is encoded by the IFNA5 gene.

Ras-related protein Rap-1b, also known as GTP-binding protein smg p21B, is a protein that in humans is encoded by the RAP1B gene.

Interferon alpha-1/13, also known as IFN-alpha-1/13, is a protein that in humans is encoded by the IFNA1 and IFNA13 genes.

DNA polymerase alpha catalytic subunit is an enzyme that in humans is encoded by the POLA1 gene.

Serum amyloid A-like 1 is a protein in humans encoded by the SAAL1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000171855 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000048806 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: IFNB1 interferon, beta 1, fibroblast".

Biron CA, Nguyen KB, Pien GC (2002). "Innate Immune Responses to LCMV Infections: Natural Killer Cells and Cytokines". Arenaviruses II. Current Topics in Microbiology and Immunology. Vol. 263. pp. 7–27. doi:10.1007/978-3-642-56055-2_2. ISBN 978-3-642-62724-8. PMID 11987821.{{cite book}}: |journal= ignored (help)
Conti L, Fantuzzi L, Del Cornò M, et al. (2005). "Immunomodulatory effects of the HIV-1 gp120 protein on antigen presenting cells: implications for AIDS pathogenesis". Immunobiology. 209 (1–2): 99–115. doi:10.1016/j.imbio.2004.02.008. PMID 15481145.
Bekisz J, Schmeisser H, Hernandez J, et al. (2005). "Human interferons alpha, beta and omega". Growth Factors. 22 (4): 243–51. doi:10.1080/08977190400000833. PMID 15621727. S2CID 84918367.
Copeland KF (2006). "Modulation of HIV-1 transcription by cytokines and chemokines". Mini Reviews in Medicinal Chemistry. 5 (12): 1093–101. doi:10.2174/138955705774933383. PMID 16375755.
Silverman RH, Sengupta DN (1991). "Translational regulation by HIV leader RNA, TAT, and interferon-inducible enzymes". J. Exp. Pathol. 5 (2): 69–77. PMID 1708818.
Flores I, Mariano TM, Pestka S (1991). "Human interferon omega (omega) binds to the alpha/beta receptor". J. Biol. Chem. 266 (30): 19875–7. doi: 10.1016/S0021-9258(18)54862-6 . PMID 1834641.
May LT, Sehgal PB (1985). "On the relationship between human interferon alpha 1 and beta 1 genes". J. Interferon Res. 5 (3): 521–6. doi:10.1089/jir.1985.5.521. PMID 2414376.
Francois DT, Katona IM, June CH, et al. (1988). "Examination of the inhibitory and stimulatory effects of IFN-alpha, -beta, and -gamma on human B-cell proliferation induced by various B-cell mitogens". Clin. Immunol. Immunopathol. 48 (3): 297–306. doi:10.1016/0090-1229(88)90023-2. PMID 3135963.
Conradt HS, Egge H, Peter-Katalinic J, et al. (1987). "Structure of the carbohydrate moiety of human interferon-beta secreted by a recombinant Chinese hamster ovary cell line". J. Biol. Chem. 262 (30): 14600–5. doi: 10.1016/S0021-9258(18)47838-6 . PMID 3667593.
Blank KJ, McKernan LN, Murasko DM (1985). "Poly I:C or IFN-alpha/beta treatment inhibits macrophage induced T cell proliferation". J. Interferon Res. 5 (1): 215–21. doi:10.1089/jir.1985.5.215. PMID 3872918.
Derynck R, Content J, DeClercq E, et al. (1980). "Isolation and structure of a human fibroblast interferon gene". Nature. 285 (5766): 542–7. Bibcode:1980Natur.285..542D. doi:10.1038/285542a0. PMID 6157094. S2CID 4272787.
Taniguchi T, Ohno S, Fujii-Kuriyama Y, Muramatsu M (1980). "The nucleotide sequence of human fibroblast interferon cDNA". Gene. 10 (1): 11–5. doi:10.1016/0378-1119(80)90138-9. PMID 6157601.
Houghton M, Easton MA, Stewart AG, et al. (1981). "The complete amino acid sequence of human fibroblast interferon as deduced using synthetic oligodeoxyribonucleotide primers of reverse transcriptase". Nucleic Acids Res. 8 (13): 2885–94. doi:10.1093/nar/8.13.2885. PMC 324132 . PMID 6159580.
Goeddel DV, Shepard HM, Yelverton E, et al. (1981). "Synthesis of human fibroblast interferon by E. coli". Nucleic Acids Res. 8 (18): 4057–74. doi:10.1093/nar/8.18.4057. PMC 324219 . PMID 6159584.
Houghton M, Stewart AG, Doel SM, et al. (1981). "The amino-terminal sequence of human fibroblast interferon as deduced from reverse transcripts obtained using synthetic oligonucleotide primers". Nucleic Acids Res. 8 (9): 1913–31. doi:10.1093/nar/8.9.1913. PMC 324047 . PMID 6159597.
Wetzel R (1981). "Assignment of the disulphide bonds of leukocyte interferon". Nature. 289 (5798): 606–7. Bibcode:1981Natur.289..606W. doi:10.1038/289606a0. PMID 6162107. S2CID 4327734.
Lawn RM, Adelman J, Franke AE, et al. (1981). "Human fibroblast interferon gene lacks introns". Nucleic Acids Res. 9 (5): 1045–52. doi:10.1093/nar/9.5.1045. PMC 326735 . PMID 6164984.
Shepard HM, Leung D, Stebbing N, Goeddel DV (1982). "A single amino acid change in IFN-beta1 abolishes its antiviral activity". Nature. 294 (5841): 563–5. doi:10.1038/294563a0. PMID 6171735. S2CID 4344841.
Content J, De Wit L, Pierard D, et al. (1982). "Secretory proteins induced in human fibroblasts under conditions used for the production of interferon beta". Proc. Natl. Acad. Sci. U.S.A. 79 (9): 2768–72. Bibcode:1982PNAS...79.2768C. doi: 10.1073/pnas.79.9.2768 . PMC 346287 . PMID 6178110.
Fiers W, Remaut E, Devos R, et al. (1983). "The human fibroblast and human immune interferon genes and their expression in homologous and heterologous cells". Philos. Trans. R. Soc. Lond. B Biol. Sci. 299 (1094): 29–38. doi:10.1098/rstb.1982.0103. PMID 6183692.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000171855 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000048806 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: IFNB1 interferon, beta 1, fibroblast".

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IFNB1

Related Research Articles

References

Further reading