Concizumab

Last updated

Concizumab
Monoclonal antibody
Type Whole antibody
Source Humanized
Target Tissue factor pathway inhibitor
Clinical data
Trade names Alhemo
Pregnancy
category
Routes of
administration
Subcutaneous
Drug class Antihemorrhagic
ATC code
Legal status
Legal status
Identifiers
CAS Number
DrugBank
UNII
KEGG
Chemical and physical data
Formula C6462H10004N1712O2046S46
Molar mass 145887.81 g·mol−1

Concizumab, sold under the brand name Alhemo, is a monoclonal antibody used for the treatment of hemophilia B. [5] It is an anti-tissue factor pathway inhibitor. [5]

Contents

Concizumab was approved for medical use in Canada in March 2023. [4] [7]

Medical uses

Concizumab is indicated for the treatment of people with hemophilia B who have factor IX inhibitors and require routine prophylaxis to prevent or reduce the frequency of bleeding episodes. [5] [6]

Society and culture

Names

Concizumab is the international nonproprietary name. [8]

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References

  1. 1 2 "Alhemo APMDS". Therapeutic Goods Administration (TGA). 29 September 2023. Archived from the original on 10 March 2024. Retrieved 7 March 2024.
  2. "Alhemo (Novo Nordisk Pharmaceuticals Pty Ltd)". Therapeutic Goods Administration (TGA). 28 July 2023. Archived from the original on 10 March 2024. Retrieved 10 September 2023.
  3. "AusPAR: Alhemo". Therapeutic Goods Administration (TGA). 18 March 2024. Retrieved 31 March 2024.
  4. 1 2 "Alhemo Product information". Health Canada. 10 March 2023. Archived from the original on 24 March 2023. Retrieved 9 June 2023.
  5. 1 2 3 4 "Alhemo (concizumab injection) Product Monograph" (PDF). Health Canada. Archived (PDF) from the original on 3 March 2024. Retrieved 3 March 2024.
  6. 1 2 "Summary Basis of Decision for Alhemo". Health Canada . 31 May 2023. Archived from the original on 10 March 2024. Retrieved 9 June 2023.
  7. "Health Canada approves Alhemo, the first subcutaneous prophylactic treatment for people living with hemophilia B with inhibitors" (Press release). Novo Nordisk Canada. 17 April 2023. Archived from the original on 9 June 2023. Retrieved 9 June 2023 via Newswire.
  8. World Health Organization (2013). "International nonproprietary names for pharmaceutical substances (INN): recommended INN: list 70". WHO Drug Information. 27 (3). hdl: 10665/331167 .