Interstate 64 (I-64) is an east–west Interstate Highway in the Eastern United States. Its western terminus is at I-70, U.S. Route 40 (US 40), and US 61 in Wentzville, Missouri. Its eastern terminus is at the Bowers Hill Interchange with I-264 and I-664 at Bower's Hill in Chesapeake, Virginia. I-64 connects Greater St. Louis, the Louisville metropolitan area, the Lexington–Fayette metropolitan area, the Charleston metropolitan area, the Greater Richmond Region, and Hampton Roads.
Interstate 69 (I-69) is an Interstate Highway in the United States currently consisting of 10 unconnected segments with an original continuous segment from Indianapolis, Indiana, northeast to the Canadian border in Port Huron, Michigan, at 355.8 miles (572.6 km). The remaining separated segments are variously completed and posted or not posted sections of an extension southwest to the Mexican border in Texas. Of this extension—nicknamed the NAFTA Superhighway because it would help trade with Canada and Mexico spurred by the North American Free Trade Agreement (NAFTA)—seven pieces in Laredo, Texas; Pharr, Texas; Brownsville, Texas; Corpus Christi, Texas; Houston, Texas; northwestern Mississippi; and Memphis, Tennessee, have been built or upgraded and signposted as I-69. Indiana is currently working on a fifth segment that will extend I-69 through the entire state while a sixth segment of I-69 through Kentucky utilizing that state's existing parkway system and a section of I-24 was established by federal legislation in 2008 with several more parkway segments being upgraded since then. This brings the total length to about 880 miles (1,420 km).
U.S. Route 27 or U.S. Highway 27 (US 27) is a north–south United States Numbered Highway in the Southern and Midwestern U.S. The southern terminus is at US 1 in Miami, Florida. The northern terminus is at Interstate 69 (I-69) in Fort Wayne, Indiana. From Miami, it goes up the center of Florida, then west to Tallahassee, Florida, and north through such cities and towns as Columbus, Georgia; Rome, Georgia; Chattanooga, Tennessee; Lexington, Kentucky; Cincinnati, Ohio; Oxford, Ohio; Richmond, Indiana; and Fort Wayne, Indiana. It once extended north through Lansing, Michigan, to Cheboygan, Mackinaw City, and, for about three years, even as far as St. Ignace. US 27 was first signed in 1926, replacing what had been the eastern route of the Dixie Highway in many states.
State Road 37 (SR 37) is a major route in the U.S. state of Indiana, running as a four-lane divided highway for 110 miles of its course.
U.S. Route 641 (US 641) is a U.S. Route in Tennessee and Kentucky. It runs for 165.45 miles (266.27 km) from US 64 south of Clifton, Tennessee to an intersection with US 60 in Marion, Kentucky. While it is considered a spur route of U.S. Route 41, the two routes no longer connect.
Interstate 265 (I-265) is a 31.21-mile (50.23 km) Interstate Highway partially encircling the Louisville metropolitan area. Starting from I-65 in the southern part of Louisville, it runs through Jefferson County, Kentucky, crosses the Ohio River on the Lewis and Clark Bridge into Indiana, meets I-65 for a second time, and then proceeds westbound to terminate at the I-64 interchange.
Interstate 275 (I-275) is an 83.71-mile-long (134.72 km) highway in Ohio, Indiana, and Kentucky that forms a complete beltway around the Cincinnati metropolitan area and includes a part in a state (Indiana) not entered by the parent route. It had been the only auxiliary Interstate that enters three states, but that changed in July 2018 when I-295 in Delaware and New Jersey was extended into Pennsylvania. It is the longest beltway with an Interstate highway designation in the United States, enclosing an area of over 250,000 acres (100,000 ha). It is also the third longest beltway overall in the United States—only the Sam Houston Tollway and the Grand Parkway encircling Greater Houston are longer. For a short distance in northwest Hamilton County, it overlaps with I-74 and US Route 52 (US 52).
Kentucky Route 80 (KY 80) is a 483.55-mile-long (778.20 km) state highway in the southern part of the U.S. state of Kentucky. The route originates on the state's western border at Columbus in Hickman County and stretches across the southern portion of the state, terminating southeast of Elkhorn City on the Virginia state line. It is the longest Kentucky State Highway, though the official distance as listed in route logs is much less due to multiple concurrencies with U.S. Route 68 (US 68) and US 23.
Dixie Highway in Palm Beach and Broward counties carries two segments of the State Road 811 designation by Florida Department of Transportation, as well as the local County Road 811 in southeast Florida. The entire road comprises a section of the Dixie Highway, a National Auto Trail which eventually became a former routing of U.S. Route 1 after the route was shifted east to Federal Highway. One segment of SR 811 is in Broward County and the other is in Palm Beach County, Florida. The segments of SR 811 are supplemented by three shorter segments of CR 811, one of which is unsigned.
State Road 101 in the U.S. state of Indiana is a north–south state highway in the eastern portion of Indiana that exists in four sections with a combined length of 79.42 miles (127.81 km).
State Road 62 (SR 62) in the U.S. state of Indiana is an east–west route that travels 204 miles (328 km) from the Illinois state line in the southwest corner of Indiana to the Louisville, Kentucky area, then northeast toward the Cincinnati, Ohio area.
State Road 69 (SR 69) is a part of the Indiana State Road system that runs between Hovey Lake Fish and Wildlife Area and Griffin in US state of Indiana. The 35.07 miles (56.44 km) of SR 69 that lie within Indiana serve as a major conduit. Some of the highway is listed on the National Highway System. Various sections are urban two-lane highway, three-lane highway and rural two-lane highway. The highway passes through residential, industrial and commercial properties.
State Road 75, the highest two-digit route in the U.S. state of Indiana consists of two discontinuous north–south segments.
U.S. Route 31W is the westernmost of two parallel routes for U.S. Route 31 from Nashville, Tennessee to Louisville, Kentucky.
Interstate 65 (I-65) in the US state of Indiana traverses from the south-southeastern Falls City area bordering Louisville, Kentucky, through the centrally located capital city of Indianapolis, to the northwestern Calumet Region of the Hoosier State which is part of the Chicago metropolitan area. The Indiana portion of I-65 begins in Jeffersonville after crossing the Ohio River and travels mainly north, passing just west of Columbus prior to reaching the Indianapolis metro area. Upon reaching Indianapolis, the route alignment of I-65 begins to run more to the northwest and subsequently passes Lafayette on that city's east and north sides. Northwest of there, in west-central Jasper County, the route again curves more northward as it approaches the Calumet Region. Shortly after passing a major junction with I-80 and I-94, I-65 reaches its northern national terminus in Gary at I-90 which is carried on the Indiana East–West Toll Road. I-65 covers 261.27 miles (420.47 km) in the state of Indiana. This is one of the principal Interstate Highways that cross the state, and, more specifically, intersect at the city of Indianapolis, that has given the state the nickname of "Crossroads of America".
Interstate 69 (I-69) currently has two discontinuous segments of freeway in the US state of Indiana. The original 157.8-mile-long (254.0 km) highway, completed in November 1971, runs northeasterly from the state capital of Indianapolis, to the city of Fort Wayne, and then proceeds north to the state of Michigan. This original segment is also known as segment of independent utility 1 (SIU 1) in the national plan for expansion of I-69.
Interstate 64 (I-64) in the US state of Indiana is a major east–west highway providing access between Illinois and Kentucky. It passes through southern Indiana as part of its connection between the two metropolitan areas of St Louis, Missouri, and Louisville, Kentucky.
Arkansas Highway 60 is a state highway that exists in five separate sections in Arkansas. The longest and most well-known segment of 54.19 miles (87.21 km) runs from Highway 28 in Plainview east to U.S. Route 65B (US 65B) in Conway. A segment in western Logan County of 2.64 miles (4.25 km) begins at the Old Highway 10 at the Sebastian County line and runs east to Highway 10. A third segment of 10.80 miles (17.38 km) begins at Highway 252 near Lavaca and runs east to Highway 41 at Peter Pender. A fourth segment runs 1.34 miles (2.16 km) from US 64 and runs across Interstate 40/Interstate 540 (I-40/I-540) to Highway 282. A fifth route of 2.34 miles (3.77 km) begins at Highway 282 near Rudy and runs north to County Road 23 (CR 23).
U.S. Route 31 (US 31) is a part of the United States Numbered Highway System that runs from Spanish Fort, Alabama, to Mackinaw City, Michigan. It enters the U.S. state of Indiana via the George Rogers Clark Memorial Bridge between Louisville, Kentucky, and Clarksville, Indiana. The 266.02 miles (428.12 km) of US 31 that lie within Indiana serve as a major conduit. Some of the highway is listed on the National Highway System. Various sections are rural two-lane highway and urbanized four- or six-lane divided expressway. The northernmost community along the highway is South Bend near the Michigan state line.
U.S. Route 231 is the longest numbered highway in Indiana, covering over 284 miles (457 km). It is a main north–south highway in the western part of the state. The southern terminus of US 231 is at the Kentucky state line and the northern terminus is at US 41 just south of St. John. The highway is a mixture of expressway and two-lane roadway. The expressway portions exist mainly in southern Indiana and around the Lafayette area, with the rest mainly being two lanes.
KY 69 at Cannelton 
SR 37 near Tell City 
SR 62 / SR 66 at Sulphur 
I-64 near Sulphur
SR 37 / SR 64 at English 
