U.S. Route 58 is an east–west U.S. Highway that runs for 508 miles (818 km) from U.S. Route 25E just northwest of Harrogate, Tennessee, to U.S. Route 60 in Virginia Beach, Virginia. Until 1996, when the Cumberland Gap Tunnel opened, US 58 ran only inside the commonwealth of Virginia. It was then extended southwest along a short piece of former US 25E, which no longer enters Virginia, to end at the new alignment in Tennessee. For most of its alignment, it closely parallels Virginia's southern border with North Carolina.
State Route 70 is a primary state highway in Lee County, Virginia, running from the Tennessee state line to U.S. Route 58 in Jonesville. Its continuation in Tennessee, also numbered State Route 70, continues south to the North Carolina state line at North Carolina Highway 208.
State Route 71 is a primary state highway in the southwest part of the U.S. state of Virginia. It runs from Gate City northeast to Lebanon, mostly through river valleys. Despite running more east–west than north–south, it is signed north–south; it parallels the similarly-oriented U.S. Route 11 and Interstate 81.
State Route 89 is a primary state highway in the U.S. state of Virginia. The state highway runs 7.85 miles (12.63 km) from the North Carolina state line, where the highway continues as North Carolina Highway 89, north to U.S. Route 58 and US 221 in Galax.
State Route 72 is a primary state highway in the southwest part of the U.S. state of Virginia. It runs from SR 71 in Gate City north to SR 65 at Fort Blackmore, northeast with SR 65 to Dungannon, and north via Coeburn to SR 83 near Clintwood.
State Route 75 is a primary state highway in the southwest part of the U.S. state of Virginia, running southwest from U.S. Route 11 and U.S. Route 58 Alternate in Abingdon to Tennessee's State Route 44.
State Route 68 is a primary state highway in the U.S. state of Virginia. Known for most of its length as Exeter Road, the state highway runs 6.13 miles (9.87 km) from the Lee–Wise county line near Keokee, where the highway continues west as SR 606, east to U.S. Route 23 Business in Appalachia.
State Route 67 is a primary state highway in the southwest part of the U.S. state of Virginia. It runs from SR 80 near Honaker east to U.S. Route 460 at Raven, east concurrently with US 460 and US 460 Business into downtown Richlands, and north to SR 616 at Jewell Ridge on the Tazewell–Buchanan county line.
State Route 16 is a primary state highway in the southwest part of the U.S. state of Virginia. It runs from the North Carolina border at North Carolina Highway 16 north to the West Virginia border at West Virginia Route 16, passing through the towns of Troutdale, Marion, and Tazewell. Highway 16 is part of a three-state route 16 that connects the Charlotte region with northwestern West Virginia.
U.S. Route 52 in Virginia runs north–south through the southwestern part of the state along the Interstate 77 (I-77) corridor. Though an even-numbered U.S. route, it is signed north–south in Virginia. In some other states along its route, it is signed east–west. The Virginia segment is signed such that US 52 north corresponds to the general westward direction of the highway, and vice versa.
In the U.S. state of Virginia, U.S. Route 220 (US 220) is a major north-south state highway that extends from the North Carolina state line through Roanoke to the West Virginia state line. South of Roanoke, US 220 is a four-lane highway within the proposed Interstate 73 (I-73) corridor. US 220 narrows to two lanes north of Roanoke, connecting to I-64 near Clifton Forge and then paralleling the Appalachian Mountains north-northeasterly in the direction of Cumberland, Maryland.
U.S. Route 19 is a part of the U.S. Highway System that runs from Memphis, Florida to Erie, Pennsylvania. In Virginia, the highway runs 88.89 miles (143.05 km) between two pairs of twin cities: Bristol, Tennessee and Bristol, Virginia, at the Virginia–Tennessee state line, and Bluefield, Virginia and Bluefield, West Virginia, at the Virginia–West Virginia state line. Between its endpoints, US 19 has lengthy concurrencies with US 11, US 58 Alternate, and US 460 during its course connecting Abingdon, Lebanon, and Tazewell within Washington, Russell, and Tazewell counties in Southwest Virginia.
Virginia State Route 9 is a primary state highway in the U.S. state of Virginia. Known as Charles Town Pike, the state highway runs 13.08 miles (21.05 km) from the West Virginia state line near Mechanicsville, where the highway continues west as West Virginia Route 9, east to SR 7 and SR 7 Business in Paeonian Springs. SR 9 is the main east–west highway of northwestern Loudoun County, connecting Leesburg with Hillsboro and the West Virginia cities of Charles Town and Martinsburg. As a result, the state highway and its West Virginia continuation are a major, overburdened commuter route between the Eastern Panhandle of West Virginia and Washington, D.C.
State Route 63 is a primary state highway in the U.S. state of Virginia. The state highway runs 39.28 miles (63.22 km) from U.S. Route 58 Alternate in St. Paul north to SR 80 and SR 83 in Haysi.
State Route 65, formerly State Route 66, is a primary state highway in the U.S. state of Virginia. The state highway runs 34.06 miles (54.81 km) from U.S. Route 23, US 58, and US 421 in Clinchport north to US 58 Alternate in Castlewood.
State Route 8 is a primary state highway in the U.S. state of Virginia. The state highway runs 55.88 miles (89.93 km) from the North Carolina state line near Palmetto, where the highway continues south as North Carolina Highway 8, north to U.S. Route 11 in Christiansburg. SR 8 is part of a 151-mile (243 km) two-state highway 8 system and is the main north–south highway of Patrick County, Floyd County, and southern Montgomery County, connecting their respective county seats of Stuart, Floyd, and Christiansburg with each other and with the Blue Ridge Parkway. The state highway also links the New River Valley region of Virginia with Southside Virginia via US 58 and the Piedmont Triad of North Carolina via NC 8.
State Route 41 is a primary state highway in the U.S. state of Virginia. Known as Franklin Turnpike, the state highway runs 22.5 miles (36.2 km) from SR 360 northeast of Danville to SR 57 in Callands. The Virginia Department of Transportation (VDOT) officially designates the route north of U.S. Route 29 Business in Danville as a part of SR 41 but the Franklin Turnpike south and east of this point is signed as SR 41.
Virginia Byway 
KY 80 near Elkhorn City, KY 
SR 83 in Haysi 
US 19 at Rosedale 
I-81 near Meadowview 
US 11 near Meadowview
