The 18th Lambda Literary Awards were held in 2006, to honor works of LGBT literature published in 2005.
| Category | Winner | Nominated |
|---|---|---|
| Anthologies | E. Lynn Harris, ed., Freedom in This Village: Twenty-Five Years of Black Gay Men's Writing, 1979 to the Present [1] |
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| Belles Lettres | Martin Moran, The Tricky Part [1] |
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| Biography | Sherrill Tippins, February House [1] |
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| Children's/Young Adult | Shyam Selvadurai, Swimming in the Monsoon Sea [1] |
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| Erotica | Stacia Seaman and Radclyffe, eds., Stolen Moments: Erotic Interludes 2 [1] |
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| Gay Debut Fiction | Vestal McIntyre, You Are Not the One: Stories [1] |
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| Gay Fiction | Dennis Cooper, The Sluts [1] |
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| Gay Mystery | D. Travers Scott, One of These Things is Not Like the Other [1] |
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| Gay Poetry | Richard Siken, Crush [1] |
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| Humor | David Rakoff, Don't Get Too Comfortable [1] |
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| Lesbian Debut Fiction | Ali Liebegott, The Beautifully Worthless [1] |
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| Lesbian Fiction | Abha Dawesar, Babyji [1] |
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| Lesbian Mystery | Alicia Gaspar de Alba, Desert Blood: The Juarez Murders [1] |
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| Lesbian Poetry | June Jordan, Directed by Desire: Collected Poems [1] |
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| LGBT Studies | Susan Ackerman, When Heroes Love: The Ambiguities of Eros in the Stories of Gilgamesh and David [1] |
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| Non-Fiction | Thomas Glave, Words to Our Now [1] |
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| Romance | Radclyffe, Distant Shores, Silent Thunder [1] |
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| Science fiction, fantasy or horror | Katherine V. Forrest, Daughters of an Emerald Dusk [1] |
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| Spirituality | Cheri DiNovo, Qu(e)erying Evangelism: Growing a Community from the Outside In [1] |
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| Transgender | Charlie Anders, Choir Boy [1] |
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