| 1991 Virginia Slims of Houston | |
|---|---|
| Date | April 15–21 |
| Edition | 21st |
| Category | Tier II |
| Draw | 28S / 16D |
| Prize money | $350,000 |
| Surface | Clay /outdoor |
| Location | Houston, Texas, U.S. |
| Venue | Westside Tennis Club |
| Champions | |
| Singles | |
 Monica Seles | |
| Doubles | |
 Jill Hetherington /  Kathy Rinaldi | |
The 1991 Virginia Slims of Houston was a women's tennis tournament played on outdoor clay courts at the Westside Tennis Club in Houston, Texas in the United States that was part of Tier II of the 1991 WTA Tour. It was the 21st edition of the tournament and was held from April 15 through April 21, 1991. First-seeded Monica Seles won the singles title and earned $70,000 first-prize money.