Defending champion Justine Henin-Hardenne successfully defended her title, defeating Svetlana Kuznetsova in the final, 6–4, 6–4 to win the women's singles tennis title at the 2006 French Open. She won the title without losing a set during the tournament, or without facing a tiebreak in any set.
Ana Ivanovic defeated Dinara Safina in the final, 6–4, 6–3 to win the women's singles tennis title at the 2008 French Open. It was her first and only major singles title. With the win, Ivanovic also became the world No. 1; Maria Sharapova, Jelena Janković and Svetlana Kuznetsova were also in contention for the top ranking. Ivanovic dropped only one set during the tournament, to Janković in the semifinals. This marked the last time Ivanovic would reach a major quarterfinal until the 2012 US Open.
Maria Sharapova defeated Ana Ivanovic in the final, 7–5, 6–3 to win the women's singles tennis title at the 2008 Australian Open. It was her third major singles title. She did not lose a set during the tournament or face a tiebreak in any set. Sharapova also became the first Russian woman to win the title. It was Ivanovic's second runner-up finish in as many major finals, though she would win the French Open a few months later.
The 2008 Qatar Ladies Open singles was the singles event of the 2008 Qatar Ladies Open, a WTA Tier I tennis tournament held in February. Justine Henin was the defending champion, but she chose not to participate that year.
Defending champion Venus Williams successfully defended her title, defeating her sister Serena Williams in the final, 7–5, 6–4 to win the ladies' singles tennis title at the 2008 Wimbledon Championships. It was her fifth Wimbledon title and seventh major singles title overall. She won the title without losing a set, the second time she did so at a major.
Serena and Venus Williams defeated Lisa Raymond and Samantha Stosur in the final, 6–2, 6–2 to win the ladies' doubles tennis title at the 2008 Wimbledon Championships. They won the title without dropping a set. The Williams sisters played against each other in the singles final as well, in which Venus emerged victorious.
Serena Williams defeated Jelena Janković in the final, 6–4, 7–5 to win the women's singles tennis title at the 2008 US Open. It was her third US Open singles title and ninth major singles title overall. With the win, she regained the world No. 1 singles ranking for the first time since 2003. This was also her second US Open and third major overall won without losing a set during the tournament. Three of the top four seeds were in contention for the No. 1 ranking at the start of the tournament.
12th seeded Serbian Ana Ivanovic was the champion, after edging 3rd seeded Russian Svetlana Kuznetsova in a thrilling last set tie-break in the finals. Nadia Petrova was the defending champion, but lost in the quarterfinals to Svetlana Kuznetsova.
Svetlana Kuznetsova was the defending champion, but chose not to participate that year.
Martina Hingis was the defending champion, but she retired from tennis the previous year.
Svetlana Kuznetsova was the defending champion, but was forced to withdraw due to a left abdominal strain.
Ágnes Szávay was the defending champion, but lost in the second round to Anabel Medina Garrigues.
Serena Williams defeated Dinara Safina in the final, 6–0, 6–3 to win the women's singles tennis title at the 2009 Australian Open. It was her fourth Australian Open singles title and her tenth major singles title overall. With the win, Williams regained the world No. 1 ranking.
Ana Ivanovic was the defending champion, but was defeated by Vera Zvonareva in the final 7–6(7–5), 6–2, in a rematch of last year's quarterfinal.
The 2009 Sony Ericsson Open women's singles was the women's singles event of the 2009 Sony Ericsson Open, a WTA Premier Mandatory tennis tournament held in Key Biscayne, Florida in late March and early April. World No. 1 Serena Williams was the defending champion and attempting to win a record sixth title at the tournament, but she lost in the final to Victoria Azarenka, 6–3, 6–1. Azarenka won her third WTA singles title and first at the Premier or above level.
Svetlana Kuznetsova defeated Dinara Safina in the final, 6–4, 6–2 to win the women's singles tennis title at the 2009 French Open. It was her second major title, after the 2004 US Open. The final marked the third all-Russian final in major singles history, and the first since the 2004 US Open. Safina fell to 0–3 in major finals with the loss. The match was also the conclusion of a series of matches between the pair during the preceding clay court season, with Kuznetsova beating Safina to win the title in Stuttgart, and Safina avenging the loss by beating Kuznetsova in Rome.
Vera Zvonareva was the defending champion, but lost in the fourth round to Samantha Stosur.
Victoria Azarenka was the defending champion, but lost to Kim Clijsters in the fourth round.
Justine Henin defeated Samantha Stosur in the final, 6–4, 2–6, 6–1 to win the women's singles tennis title at the 2010 Stuttgart Open. This was Henin's first title since 2008, the year she first retired from professional tennis. Svetlana Kuznetsova was the defending champion, but she lost to Li Na in the second round.
Venus Williams was the two-time defending champion, but withdrew before the tournament started due to injury.
Svetlana Kuznetsova 
Ágnes Szávay 
