| Singles | |
|---|---|
| 2015 Comerica Bank Challenger | |
| Champion |  John Millman |
| Runner-up |  Austin Krajicek |
| Final score | 7–5, 2–6, 6–3 |
Marcos Baghdatis was the defending champion but chose not to compete.
John Millman won the tournament, defeating Austin Krajicek in the final, 7–5, 2–6, 6–3.
John Millman (champion)
Malek Jaziri (quarterfinals)
Kyle Edmund (semifinals) Bjorn Fratangelo (semifinals)
Taro Daniel (quarterfinals) Matthew Ebden (quarterfinals) Austin Krajicek (final) Yoshihito Nishioka (quarterfinals)| Semifinals | Final | ||||||||||||
| 1 | John Millman | 3 | 6 | 7 | |||||||||
| 3 | Kyle Edmund | 6 | 4 | 5 | |||||||||
| 1 | John Millman | 7 | 2 | 6 | |||||||||
| 7 | Austin Krajicek | 5 | 6 | 3 | |||||||||
| 4 | Bjorn Fratangelo | 3 | 62 | ||||||||||
| 7 | Austin Krajicek | 6 | 77 | ||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | J Millman | 6 | 6 | ||||||||||||||||||||||||
| Alt | A Sarkissian | 2 | 0 | 1 | J Millman | 6 | 6 | ||||||||||||||||||||
| B Klein | 4 | 4 |  G Andreozzi | 3 | 2 | ||||||||||||||||||||||
| G Andreozzi | 6 | 6 | 1 | J Millman | 6 | 6 | |||||||||||||||||||||
 F Dustov | 1 | 6 | 6 | 5 | T Daniel | 1 | 3 | ||||||||||||||||||||
| Q | T Sandgren | 6 | 2 | 1 | F Dustov | 77 | 5 | 0 | |||||||||||||||||||
| Q |  Z Zhang | 66 | 2 | 5 | T Daniel | 65 | 7 | 6 | |||||||||||||||||||
| 5 | T Daniel | 78 | 6 | 1 | J Millman | 3 | 6 | 7 | |||||||||||||||||||
| 3 | K Edmund | 6 | 6 | 3 | K Edmund | 6 | 4 | 5 | |||||||||||||||||||
| LL | T Niki | 1 | 2 | 3 | K Edmund | 7 | 6 | ||||||||||||||||||||
 J Zopp | 4 | 4 | Q | D Nguyen | 5 | 3 | |||||||||||||||||||||
| Q | D Nguyen | 6 | 6 | 3 | K Edmund | 3 | 6 | 6 | |||||||||||||||||||
| WC | J Donaldson | 77 | 6 | 8 | Y Nishioka | 6 | 3 | 3 | |||||||||||||||||||
 G Elias | 62 | 3 | WC | J Donaldson | 6 | 3 | 3 | ||||||||||||||||||||
| WC | M Krueger | 3 | 6 | 3 | 8 | Y Nishioka | 4 | 6 | 6 | ||||||||||||||||||
| 8 | Y Nishioka | 6 | 1 | 6 | |||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 6 | M Ebden | 77 | 6 | ||||||||||||||||||||||||
| L Broady | 64 | 3 | 6 | M Ebden | 2 | 77 | 6 | ||||||||||||||||||||
| WC |  T Haas | 6 | 6 | WC | T Haas | 6 | 65 | 4 | |||||||||||||||||||
 A Rublev | 4 | 3 | 6 | M Ebden | 4 | 2 | |||||||||||||||||||||
 Y Bhambri | 2 | 2 | 4 | B Fratangelo | 6 | 6 | |||||||||||||||||||||
 E Ymer | 6 | 6 | E Ymer | 3 | 4 | ||||||||||||||||||||||
 M Copil | 6 | 5 | 2 | 4 | B Fratangelo | 6 | 6 | ||||||||||||||||||||
| 4 | B Fratangelo | 3 | 7 | 6 | 4 | B Fratangelo | 3 | 62 | |||||||||||||||||||
| 7 | A Krajicek | 64 | 6 | 79 | 7 | A Krajicek | 6 | 77 | |||||||||||||||||||
| Alt | D Novikov | 77 | 4 | 67 | 7 | A Krajicek | 6 | 6 | |||||||||||||||||||
| Q | M Zverev | 61 | 7 | 6 | Q | M Zverev | 3 | 4 | |||||||||||||||||||
| WC | TH Fritz | 77 | 5 | 3 | 7 | A Krajicek | 6 | 6 | |||||||||||||||||||
 G Clezar | 6 | 1 | 6 | 2 | M Jaziri | 3 | 4 | ||||||||||||||||||||
| S Devvarman | 2 | 6 | 3 | G Clezar | 3 | 6 | 3 | ||||||||||||||||||||
| K Khachanov | 3 | 1 | 2 | M Jaziri | 6 | 3 | 6 | ||||||||||||||||||||
| 2 | M Jaziri | 6 | 6 | ||||||||||||||||||||||||
Thomas Johansson was the defending champion but lost in the semifinal 6–4, 6–4 against Richard Krajicek.
Juan Martín del Potro was the defending champion, but chose to compete in Dubai instead.
Kevin Anderson won the title after defeating Marinko Matosevic 6–4, 7–6(7–2) in the final.
Jordan Kerr and David Martin were the defending champions but decided not to participate.
Austin Krajicek and John Peers won the title, defeating Tennys Sandgren and Rhyne Williams 6–1, 7–6(7–4) in the final.
Devin Britton and Austin Krajicek were the defending champions but Britton decided not to participate.
Krajicek partnered with Tennys Sandgren, but lost in the final to the British pairing of Edward Corrie and Daniel Smethurst 7–6(7–5), 0–6, [10–7].
This was the first edition of the tournament.
Nicolas Mahut was the defending champion, but lost in the quarterfinals to Samuel Groth.
Lleyton Hewitt won the title, defeating Ivo Karlović in the final, 6–3, 6–7(4–7), 7–6(7–3).
Austin Krajicek won his maiden ATP Challenger Tour singles title, beating João Souza 7–5, 6–3
Austin Krajicek and Tennys Sandgren were the defending champions.
Rajeev Ram was the defending champion, but lost in the second round to Daniel Nguyen.
John Isner was the two-time defending champion, and he won the title for the third straight year, defeating Marcos Baghdatis in the final, 6–3, 6–3.
Austin Krajicek and John-Patrick Smith were the defending champions, but Smith did not participate this year. Krajicek partnered with Nicholas Monroe, but lost in the quarterfinals to Yuki Bhambri and Michael Venus.
Dennis Novikov won the all American final, beating Ryan Harrison 6–4, 7–5
Andy Murray was the defending champion but chose not to participate this year.
Tomáš Berdych won the title, defeating Guillermo García-López in the final, 6–3, 7–6(9–7).
Kei Nishikori was the defending champion, but lost to Benoît Paire in the semifinals.
Ruben Bemelmans was the defending champion, but decided not to defend his title.
Nicolas Mahut was the defending champion and successfully defended his title, defeating Gilles Müller in the final, 6–4, 6–4.
Marcelo Arévalo and Miguel Ángel Reyes-Varela were the defending champions, but lost in the first round to Hans Hach Verdugo and Dennis Novikov.
Philipp Oswald and Filip Polášek were the defending champions, but chose to participate with different partners. Oswald partnered Marcus Daniell and lost in the quarterfinals to Marcel Granollers and Horacio Zeballos. Polášek partnered Ivan Dodig and lost in the semifinals to Austin Krajicek and Franko Škugor.
Austin Krajicek and Franko Škugor were the defending champions, but Krajicek chose to compete at the Summer Olympics and Škugor chose not to defend his title.
Łukasz Kubot and Marcelo Melo were the reigning champions from when the tournament was last held in 2019, but lost in the semifinals to Ivan Dodig and Austin Krajicek.