| Singles | |
|---|---|
| 2016 Soho Square Ladies Tournament | |
| Champion |  Donna Vekić |
| Runner-up |  Sara Sorribes Tormo |
| Score | 6–2, 6–7(7–9), 6–3 |
Victoria Kan is the defending champion, having won the previous edition in 2013.
Donna Vekić won the title, defeating Sara Sorribes Tormo in the final, 6–2, 6–7(7–9), 6–3.
Nao Hibino (first round)
Maria Sakkari (semifinals)
Ana Bogdan (second round) Donna Vekić (champion) Sara Sorribes Tormo (final) Sílvia Soler Espinosa (second round)
Cindy Burger (second round)
Amra Sadiković (withdrew)| Semifinals | Final | ||||||||||||
 Anastasiya Komardina | |||||||||||||
| 5 | Sara Sorribes Tormo | w/o | |||||||||||
| 5 | Sara Sorribes Tormo | 2 | 79 | 3 | |||||||||
| 4 | Donna Vekić | 6 | 67 | 6 | |||||||||
| 4 | Donna Vekić | 63 | 6 | 6 | |||||||||
| 2 | Maria Sakkari | 77 | 4 | 1 | |||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | N Hibino | 1 | 2 | ||||||||||||||||||||||||
| A Komardina | 6 | 6 | A Komardina | 5 | 6 | 6 | |||||||||||||||||||||
| Q |  J Wachaczyk | 6 | 6 | Q | J Wachaczyk | 7 | 2 | 2 | |||||||||||||||||||
 A Raina | 4 | 1 | A Komardina | 63 | 6 | 7 | |||||||||||||||||||||
| Q |  D Yastremska | 6 | 6 | Q | D Yastremska | 77 | 1 | 5 | |||||||||||||||||||
| C Dinu | 4 | 3 | Q | D Yastremska | 4 | 6 | 6 | ||||||||||||||||||||
| J Teichmann | 4 | 3 | 6 | S Soler Espinosa | 6 | 1 | 1 | ||||||||||||||||||||
| 6 | S Soler Espinosa | 6 | 6 | A Komardina | |||||||||||||||||||||||
| 3 | A Bogdan | 6 | 6 | 5 | S Sorribes Tormo | w/o | |||||||||||||||||||||
| G García Pérez | 4 | 4 | 3 | A Bogdan | 6 | 5 | 3 | ||||||||||||||||||||
| IM Bara | 5 | 6 | 2 |  L Gjorcheska | 3 | 7 | 6 | ||||||||||||||||||||
| L Gjorcheska | 7 | 1 | 6 | L Gjorcheska | 7 | 3 | 3 | ||||||||||||||||||||
 A-S Mestach | 6 | 6 | 5 | S Sorribes Tormo | 5 | 6 | 6 | ||||||||||||||||||||
 B Eraydın | 4 | 1 | A-S Mestach | 2 | 5 | ||||||||||||||||||||||
 A Amanmuradova | 6 | 3 | 1 | 5 | S Sorribes Tormo | 6 | 7 | ||||||||||||||||||||
| 5 | S Sorribes Tormo | 3 | 6 | 6 | |||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| LL |  S Samir | 4 | 4 | ||||||||||||||||||||||||
| A Rus | 6 | 6 | A Rus | 6 | 6 | ||||||||||||||||||||||
| Q |  G Gatto-Monticone | 6 | 6 | Q | G Gatto-Monticone | 1 | 4 | ||||||||||||||||||||
| WC | L Alhussein Abdel Aziz | 0 | 1 | A Rus | 0 | 6 | 1 | ||||||||||||||||||||
| Q | J Cristian | 6 | 6 | 4 | D Vekić | 6 | 4 | 6 | |||||||||||||||||||
 RL Jani | 2 | 2 | Q | J Cristian | |||||||||||||||||||||||
 L Pigossi | 1 | 1 | 4 | D Vekić | w/o | ||||||||||||||||||||||
| 4 | D Vekić | 6 | 6 | 4 | D Vekić | 63 | 6 | 6 | |||||||||||||||||||
| 7 | C Burger | 7 | 6 | 2 | M Sakkari | 77 | 4 | 1 | |||||||||||||||||||
| WC | AB Mihăilă | 5 | 2 | 7 | C Burger | 2 | 3 | ||||||||||||||||||||
 K Muchová | 6 | 6 | K Muchová | 6 | 6 | ||||||||||||||||||||||
| N Dascălu | 4 | 4 | K Muchová | 4 | 1 | ||||||||||||||||||||||
| WC | O Abou Zekry | 1 | 2 | 2 | M Sakkari | 6 | 6 | ||||||||||||||||||||
| WC | V Diatchenko | 6 | 6 | WC | V Diatchenko | 4 | 3 | ||||||||||||||||||||
| A Grymalska | 5 | 1 | 2 | M Sakkari | 6 | 6 | |||||||||||||||||||||
| 2 | M Sakkari | 7 | 6 | ||||||||||||||||||||||||
Gabrielle Andrews and Taylor Townsend were the defending champions having won the 2012 event, but neither player chose to defend their title.
Kurumi Nara was the defending champion, but chose to compete in Dubai instead.
Karin Knapp was the defending champion but chose not to enter the tournament this year.
Nao Hibino won the title, defeating Donna Vekić in the final, 6–2, 6–2.
Johanna Larsson was the defending champion, but lost in the semifinals to Kateřina Siniaková.
Johanna Konta defeated Caroline Wozniacki in the final, 6–4, 6–3 to win the women's singles tennis title at the 2017 Miami Open.
Elina Svitolina defeated Simona Halep in the final, 4–6, 7–5, 6–1 to win the women's singles tennis title at the 2017 Italian Open.
Zarina Diyas was the defending champion, but chose to participate in Nottingham instead.
Stefanie Vögele won the title, defeating Sara Sorribes Tormo in the final in straight sets: 6–4, 6–2. Johanna Larsson was the defending champion, but chose not to participate.
Naomi Broady and Sara Sorribes Tormo were the defending champions, but Broady chose not to participate and Sorribes Tormo chose to compete in Charleston instead.
Karolína Plíšková was the defending champion, but lost in the second round to Victoria Azarenka.
Anna Blinkova and Raluca Olaru were the defending champions, but chose not to participate this year.
Tatjana Maria was the defending champion, but chose not to participate this year.
Misaki Doi was the defending champion, but lost to Priscilla Hon in the first round.
Alena Fomina and Valentina Ivakhnenko were the defending champions, but lost in the semifinals to Georgina García Pérez and Sara Sorribes Tormo.
Christina McHale was the defending champion but chose to compete at the 2020 Italian Open instead.
This was the first edition of the tournament, primarily organised due to the cancellation of many tournaments during the 2020 season, because of the ongoing COVID-19 pandemic.
Veronika Kudermetova was the defending champion from 2019, when the tournament was last held as a WTA 125K series event, but she chose to compete in Dubai instead.
This was the first edition of the tournament.
Anastasia Potapova defeated Veronika Kudermetova in the final, 6–3, 6–1 to win the singles title at the 2022 İstanbul Cup. It was her maiden WTA Tour title.