| Men's singles | |
|---|---|
| 2017 Fergana Challenger | |
| Champion |  Ilya Ivashka |
| Runner-up |  Nikola Milojević |
| Final score | 6–4, 6–3 |
Radu Albot was the defending champion but chose not to defend his title.
Ilya Ivashka won the title after defeating Nikola Milojević 6–4, 6–3 in the final.
Blaž Kavčič (semifinals)
Lee Duck-hee (first round) Nikola Milojević (final) Ilya Ivashka (champion)
Brayden Schnur (quarterfinals)
Alexander Kudryavtsev (first round)
Cem İlkel (quarterfinals)
Prajnesh Gunneswaran (quarterfinals)| Semifinals | Final | ||||||||||||
| 1 | Blaž Kavčič | 4 | 3 | ||||||||||
| 4 | Ilya Ivashka | 6 | 6 | ||||||||||
| 4 | Ilya Ivashka | 6 | 6 | ||||||||||
| 3 | Nikola Milojević | 4 | 3 | ||||||||||
| 3 | Nikola Milojević | 6 | 6 | ||||||||||
 Edan Leshem | 2 | 1 | |||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | B Kavčič | 64 | 6 | 6 | |||||||||||||||||||||||
 Yuya Kibi | 77 | 0 | 0 | 1 | B Kavčič | 6 | 5 | 6 | |||||||||||||||||||
 S Bangoura | 6 | 6 | S Bangoura | 2 | 7 | 2 | |||||||||||||||||||||
| Q | Dmitry Surchenko | 1 | 2 | 1 | B Kavčič | 4 | 6 | 6 | |||||||||||||||||||
| Q |  T Khabibulin | 4 | 6 | 6 | 7 | C İlkel | 6 | 4 | 0 | ||||||||||||||||||
| WC |  Amal Sultanbekov | 6 | 4 | 3 | Q | T Khabibulin | 3 | 2 | |||||||||||||||||||
| WC | Azizkhon Turgunov | 0 | 4 | 7 | C İlkel | 6 | 6 | ||||||||||||||||||||
| 7 | C İlkel | 6 | 6 | 1 | B Kavčič | 4 | 3 | ||||||||||||||||||||
| 4 | I Ivashka | 6 | 6 | 4 | I Ivashka | 6 | 6 | ||||||||||||||||||||
| Q | Pavel Tsoy | 0 | 2 | 4 | I Ivashka | 6 | 6 | ||||||||||||||||||||
| Shuichi Sekiguchi | 6 | 3 | 7 | S Sekiguchi | 2 | 2 | |||||||||||||||||||||
 V Manafov | 4 | 6 | 5 | 4 | I Ivashka | 6 | 6 | ||||||||||||||||||||
| A Yakovlev | 3 | 1 | 5 | B Schnur | 2 | 1 | |||||||||||||||||||||
| S Fomin | 6 | 6 | S Fomin | 1 | 3 | ||||||||||||||||||||||
| S Balaji | 5 | 3 | 5 | B Schnur | 6 | 6 | |||||||||||||||||||||
| 5 | B Schnur | 7 | 6 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 6 | A Kudryavtsev | 6 | 4 | 64 | |||||||||||||||||||||||
 H Hurkacz | 4 | 6 | 77 | H Hurkacz | 6 | 4 | 6 | ||||||||||||||||||||
 D Duldaev | 6 | 6 | D Duldaev | 2 | 6 | 3 | |||||||||||||||||||||
| WC | Saida'Lo Saidkarimov | 2 | 1 | H Hurkacz | 4 | 4 | |||||||||||||||||||||
| F Dustov | 6 | 1r | 3 | N Milojević | 6 | 6 | |||||||||||||||||||||
| S Fayziev | 4 | 2 | S Fayziev | 78 | 3 | 64 | |||||||||||||||||||||
| WC | Sharobiddin Abzalov | 0 | 4 | 3 | N Milojević | 66 | 6 | 77 | |||||||||||||||||||
| 3 | N Milojević | 6 | 6 | 3 | N Milojević | 6 | 6 | ||||||||||||||||||||
| 8 | P Gunneswaran | 6 | 6 | E Leshem | 2 | 1 | |||||||||||||||||||||
| Q | S Betov | 2 | 4 | 8 | P Gunneswaran | 6 | 3 | ||||||||||||||||||||
 K-M Maamoun | 65 | 6 | 3 | Y Shyla | 4 | 1r | |||||||||||||||||||||
| Y Shyla | 77 | 3 | 6 | 8 | P Gunneswaran | 77 | 65 | 3 | |||||||||||||||||||
| E Leshem | 4 | E Leshem | 63 | 77 | 6 | ||||||||||||||||||||||
| T Ismailov | 0r | E Leshem | 1 | 6 | 6 | ||||||||||||||||||||||
| V Vardhan | 64 | 6 | 77 | V Vardhan | 6 | 4 | 4 | ||||||||||||||||||||
| 2 | D-h Lee | 77 | 2 | 64 | |||||||||||||||||||||||
Teymuraz Gabashvili was the defending champion, but decided not to defend his title.
Yūichi Sugita was the defending champion but chose not to defend his title.
Two-time defending champion Rafael Nadal successfully defended his title, defeating Stefanos Tsitsipas in the final, 6–2, 6–1. By winning the title, Nadal retained the ATP no. 1 singles ranking. It was Nadal's record-extending eleventh Barcelona Open title and his 20th ATP 500 title overall, equaling Roger Federer's record. It was Tsitsipas' maiden ATP final.
Márton Fucsovics was the defending champion but chose not to defend his title.
Ilya Ivashka was the defending champion but chose not to defend his title.
Damir Džumhur was the defending champion, but lost in the quarterfinals to Stan Wawrinka.
Jo-Wilfried Tsonga was the defending champion, but lost in the second round to Gaël Monfils.
Alexander Zverev was the two-time defending champion but chose not to defend his title.
Dominic Thiem was the defending champion, but chose to compete in the Laver Cup instead.
Karen Khachanov was the defending champion, but lost in the quarterfinals to Andreas Seppi.
This was the first edition of the tournament.
Kevin Anderson was the defending champion, but chose not to participate this year.
Prajnesh Gunneswaran was the defending champion but lost in the third round to Benjamin Bonzi.
Stefanos Tsitsipas was the defending champion and successfully defended his title, defeating Félix Auger-Aliassime in the final, 6–3, 6–4.
The tournament was played on a hard surface. Due to the ongoing COVID-19 pandemic and many ATP tournaments having been cancelled, this year's event was upgraded to ATP 500 level.
Ugo Humbert was the defending champion but chose not to defend his title.
Jannik Sinner was the defending champion but chose not to defend his title.
Alexander Zverev was the defending champion from when the event was held in 2019, but chose not to defend his title.
Matteo Berrettini was the defending champion from when the event was last held in 2019, but could not participate since he was still competing in the 2021 French Open at the beginning of the tournament.
Taylor Fritz was the defending champion from when the event was last held in 2019, but withdrew before the tournament with a knee injury.