| Doubles | |
|---|---|
| 2017 Tiburon Challenger | |
| Champions |  André Göransson  Florian Lakat |
| Runners-up |  Marcelo Arévalo  Miguel Ángel Reyes-Varela |
| Final score | 6–4, 6–4 |
Matt Reid and John-Patrick Smith were the defending champions but chose not to defend their title.
André Göransson and Florian Lakat won the title after defeating Marcelo Arévalo and Miguel Ángel Reyes-Varela 6–4, 6–4 in the final.
Marcelo Arévalo / Miguel Ángel Reyes-Varela (final)
Luke Bambridge / 
David O'Hare (semifinals) Brydan Klein / Joe Salisbury (quarterfinals)
Miķelis Lībietis / Andreas Siljeström (quarterfinals)| First round | Quarterfinals | Semifinals | Final | ||||||||||||||||||||||||
| 1 | M Arévalo MÁ Reyes-Varela | 64 | 6 | [11] | |||||||||||||||||||||||
 D King C Norrie | 77 | 3 | [9] | 1 | M Arévalo MÁ Reyes-Varela | 77 | 6 | ||||||||||||||||||||
| WC |  D Baughman M Mmoh | 6 | 66 | [6] | PR |  R Bemelmans  F Dancevic | 65 | 4 | |||||||||||||||||||
| PR | R Bemelmans F Dancevic | 0 | 78 | [10] | 1 | M Arévalo MÁ Reyes-Varela | 6 | 6 | |||||||||||||||||||
| 3 | B Klein J Salisbury | 3 | 6 | [10] | PR |  A González  R Quiroz | 3 | 4 | |||||||||||||||||||
| D Kudla M McDonald | 6 | 1 | [8] | 3 | B Klein J Salisbury | 3 | 6 | [3] | |||||||||||||||||||
| PR | A González R Quiroz | 7 | 6 | PR | A González R Quiroz | 6 | 4 | [10] | |||||||||||||||||||
| WC | John Lamble B Saraiva | 5 | 4 | 1 | M Arévalo MÁ Reyes-Varela | 4 | 4 | ||||||||||||||||||||
| S Bangoura E King | 6 | 4 | [12] | WC | A Göransson F Lakat | 6 | 6 | ||||||||||||||||||||
| WC | A Göransson F Lakat | 2 | 6 | [14] | WC | A Göransson F Lakat | 6 | 6 | |||||||||||||||||||
M Krueger  R Roelofse | 1 | 6 | [7] | 4 | M Lībietis A Siljeström | 4 | 3 | ||||||||||||||||||||
| 4 | M Lībietis A Siljeström | 6 | 2 | [10] | WC | A Göransson F Lakat | 6 | 7 | |||||||||||||||||||
H Hach Verdugo  R Ramanathan | 1 | 1 | 2 | L Bambridge D O'Hare | 3 | 5 | |||||||||||||||||||||
| Q | T Fawcett  E Leshem | 6 | 6 | Q | T Fawcett E Leshem | 4 | 4 | ||||||||||||||||||||
| T Sandgren T Smyczek | 3 | 6 | [5] | 2 | L Bambridge D O'Hare | 6 | 6 | ||||||||||||||||||||
| 2 | L Bambridge D O'Hare | 6 | 3 | [10] | |||||||||||||||||||||||
Roberto Maytín and Hans Podlipnik-Castillo are the defending champions, but Maytín has partnered with Miguel Ángel Reyes-Varela and Podlipnik-Castillo has chosen not to participate. Roberto Maytín and Miguel Ángel Reyes-Varela are defeated by Ariel Behar and Giovanni Lapentti in the quarterfinals.
Daniele Bracciali and Potito Starace were the defending champions, but could not defend their title due to being banned from tennis for betting offences.
Evan King and Denis Kudla were the defending champions but only King chose to defend his title, partnering Christopher Eubanks. King successfully defended his title.
The doubles event at the 2017 Milo Open Cali was won by Marcelo Arévalo and Miguel Ángel Reyes-Varela. Nicolás Jarry and Hans Podlipnik-Castillo were the defending champions but chose not to defend their title and did not participate in the 2017 event. Arévalo and Reyes-Varela won the title after defeating Sergio Galdós and Fabrício Neis 6–3, 6–4 in the final.
Ariel Behar and Fabiano de Paula were the defending champions but chose to defend their title with different partners. Behar partnered Attila Balázs but lost in the semifinals to Marcelo Arévalo and Miguel Ángel Reyes-Varela. De Paula partnered Sergio Galdós but lost in the first round to Hugo Dellien and Federico Zeballos.
Roberto Quiroz and Caio Zampieri were the defending champions but only Quiroz chose to defend his title, partnering Yannick Hanfmann. Quiroz lost in the quarterfinals to Jay Clarke and Kevin Krawietz.
Ruan Roelofse and Christopher Rungkat were the defending champions but chose not to defend their title.
Aisam-ul-Haq Qureshi and Rajeev Ram were the defending champions but Ram chose not to participate and Qureshi chose to compete in Båstad instead.
Juan Sebastián Cabal and Treat Huey were the defending champions, but Huey chose not to participate and Cabal chose to compete in Washington instead.
This was the first edition of the tournament.
Marcelo Arévalo and Miguel Ángel Reyes-Varela were the defending champions but only Arévalo chose to defend his title, partnering Roberto Maytín. Arévalo lost in the first round to Luis David Martínez and David Pérez Sanz.
Christopher Eubanks and Evan King were the defending champions but only King chose to defend his title, partnering Nathan Pasha. King lost in the first round to Thanasi Kokkinakis and Matt Reid.
Juan Ignacio Londero and Luis David Martínez were the defending champions but only Londero chose to defend his title, partnering Tomás Lipovsek Puches. Londero lost in the semifinals to Leander Paes and Miguel Ángel Reyes-Varela.
Leander Paes and Purav Raja were the defending champions but only Paes chose to defend his title, partnering Miguel Ángel Reyes-Varela. Paes lost in the quarterfinals to Alex Lawson and Jackson Withrow.
Marcelo Arévalo and Miguel Ángel Reyes-Varela were the defending champions and successfully defended their title, defeating Ariel Behar and Roberto Quiroz 1–6, 6–4, [12–10] in the final.
Marcelo Arévalo and Miguel Ángel Reyes-Varela were the defending champions, but lost in the first round to Hans Hach Verdugo and Dennis Novikov.
Thanasi Kokkinakis and Matt Reid were the defending champions but only Reid chose to defend his title, partnering Jonny O'Mara. Reid lost in the first round to Egor Gerasimov and Li Zhe.
Leander Paes and Miguel Ángel Reyes-Varela were the defending champions but only Reyes-Varela chose to defend his title, partnering Marcelo Arévalo. Reyes-Varela lost in the semifinals to Orlando Luz and Luis David Martínez.
Marcelo Arévalo and Roberto Maytín were the defending champions but chose to defend their title with different partners. Arévalo partnered Miguel Ángel Reyes-Varela but lost in the first round to Ruben Gonzales and Ruan Roelofse. Maytín partnered Robert Galloway but lost in the first round to Nathan Pasha and Max Schnur.
Feliciano López and Stefanos Tsitsipas defeated Marcelo Arévalo and Jean-Julien Rojer in the final, 7–5, 6–4 to win the doubles title at the 2022 Mexican Open.