Wesley Koolhof and Matwé Middelkoop were the defending champions but chose not to defend their title.
David Pérez Sanz and Max Schnur were the defending champions but chose not to defend their title.
Robin Haase and Tim Pütz were the defending champions but chose not to defend their title.
Evgeny Donskoy and Mikhail Elgin were the defending champions but chose not to defend their title.
Ken and Neal Skupski were the defending champions but chose not to defend their title.
Sander Gillé and Joran Vliegen were the defending champions but only Vliegen chose to defend his title, partnering Rameez Junaid. Vliegen lost in the quarterfinals to Pedro Martínez and David Vega Hernández.
Sander Gillé and Joran Vliegen were the defending champions but chose not to defend their title.
The 2018 Advantage Cars Prague Open, also known as Advantage Cars Prague Open by Sport-Technik Bohemia for sponsorship reasons, was a professional tennis tournament played on outdoor clay courts. It was the 25th (ATP) and fourth (ITF) editions of the tournament and was part of the 2018 ATP Challenger Tour and also of the 2018 ITF Women's Circuit as 14th edition of the tournament. It took place in Prague, Czech Republic, on 23–29 July 2018.
Laurynas Grigelis and Zdeněk Kolář were the defending champions but chose not to defend their title.
Sander Arends and Antonio Šančić were the defending champions but only Šančić chose to defend his title, partnering Purav Raja. Šančić lost in the finals to Sander Gillé and Joran Vliegen.
Lorenzo Sonego and Andrea Vavassori were the defending champions but only Vavassori chose to defend his title, partnering Julian Ocleppo. Vavassori lost in the first round to Laurynas Grigelis and Alessandro Motti.
Facundo Bagnis and Ariel Behar were the defending champions but only Bagnis chose to defend his title, partnering Franco Agamenone. Bagnis lost in the first round to Sander Gillé and Joran Vliegen.
Elliot Benchetrit and Geoffrey Blancaneaux were the defending champions but only Benchetrit chose to defend his title, partnering Johan Tatlot. Benchetrit and Tatlot withdrew before the tournament began.
The men's doubles of the 2019 Advantage Cars Prague Open tournament was played on clay in Prague, Czech Republic.
Matteo Berrettini and Daniele Bracciali were the defending champions, but chose not to participate this year.
Roman Jebavý and Andrés Molteni were the defending champions, but chose not to participate together. Jebavý played alongside Matwé Middelkoop but lost in the semifinals to Philipp Oswald and Filip Polášek. Molteni partnered Leonardo Mayer but lost in the first round to Oliver Marach and Jürgen Melzer.
Sander Gillé and Joran Vliegen were the defending champions but lost in the first round to Sander Arends and David Pel.
Sander Gillé and Joran Vliegen were the defending champions but chose not to defend their title.
Sander Gillé and Joran Vliegen were the reigning champions from when the tournament was last held in 2019, but chose not to defend their title.
Rafael Matos and David Vega Hernández defeated Andrea Vavassori and Jan Zieliński in the final, 6–1, 7–5, to win the doubles tennis title at the 2022 Grand Prix Hassan II.
Sander Gillé 
Fernando Romboli 
David Vega Hernández 
