| Singles | |
|---|---|
| 2018 Ladies Open Hechingen | |
| Champion |  Ekaterine Gorgodze |
| Runner-up |  Laura Siegemund |
| Final score | 6–2, 6–1 |
Tamara Korpatsch was the defending champion, but lost in the semifinals to Laura Siegemund.
Ekaterine Gorgodze won the title, defeating Siegemund in the final 6–2, 6–1.
Carina Witthöft (first round; retired) Antonia Lottner (second round)
Jil Teichmann (second round)
Bibiane Schoofs (second round) Laura Siegemund (final) Ekaterine Gorgodze (champion)
Dejana Radanović (first round; retired) Anna Zaja (semifinals)| Semifinals | Final | ||||||||||||
| 6 | Ekaterine Gorgodze | 78 | 6 | ||||||||||
| 8 | Anna Zaja | 66 | 1 | ||||||||||
| 6 | Ekaterine Gorgodze | 6 | 6 | ||||||||||
| 5 | Laura Siegemund | 2 | 1 | ||||||||||
| 5 | Laura Siegemund | 6 | 6 | ||||||||||
| Q | Tamara Korpatsch | 3 | 4 | ||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1/WC | C Witthöft | 3 | 1r | ||||||||||||||||||||||||
| K Hobgarski | 6 | 4 | K Hobgarski | 1 | 6 | 6 | |||||||||||||||||||||
 A Roșca | 6 | 4 | 2 |  A Grymalska | 6 | 3 | 1 | ||||||||||||||||||||
| A Grymalska | 2 | 6 | 6 | K Hobgarski | 2 | 6 | 2 | ||||||||||||||||||||
| S Rubini | 1 | 5 | 6 | E Gorgodze | 6 | 2 | 6 | ||||||||||||||||||||
| WC | A Gabric | 6 | 7 | WC | A Gabric | 2 | 1 | ||||||||||||||||||||
| G Gatto-Monticone | 1 | 2 | 6 | E Gorgodze | 6 | 6 | |||||||||||||||||||||
| 6 | E Gorgodze | 6 | 6 | 6 | E Gorgodze | 78 | 6 | ||||||||||||||||||||
| 3 | J Teichmann | 6 | 6 | 8 | A Zaja | 66 | 1 | ||||||||||||||||||||
| A Cadanțu | 2 | 0 | 3 | J Teichmann | 1 | 6 | 2 | ||||||||||||||||||||
| Q |  V Flink | 6 | 6 | Q | V Flink | 6 | 2 | 6 | |||||||||||||||||||
 T Mrdeža | 1 | 2 | Q | V Flink | 3 | 64 | |||||||||||||||||||||
| Q | J Niemeier | 4 | 2 | 8 | A Zaja | 6 | 77 | ||||||||||||||||||||
 D Seguel | 6 | 6 | D Seguel | 4 | 2 | ||||||||||||||||||||||
 M Hončová | 2 | 3 | 8 | A Zaja | 6 | 6 | |||||||||||||||||||||
| 8 | A Zaja | 6 | 6 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 5 | L Siegemund | 4 | 6 | 6 | |||||||||||||||||||||||
| Q |  A Zarycká | 6 | 1 | 2 | 5 | L Siegemund | 6 | 6 | |||||||||||||||||||
| R Šramková | 7 | 4 | 1 |  C Scholl | 2 | 3 | |||||||||||||||||||||
| C Scholl | 5 | 6 | 6 | 5 | L Siegemund | 6 | 6 | ||||||||||||||||||||
| WC | L Rüffer | 77 | 1 | 6 | WC | L Rüffer | 4 | 2 | |||||||||||||||||||
| LL |  E Kordolaimi | 65 | 6 | 3 | WC | L Rüffer | 6 | 6 | |||||||||||||||||||
| P Monova | 0 | 1 | 4 | B Schoofs | 2 | 3 | |||||||||||||||||||||
| 4 | B Schoofs | 6 | 6 | 5 | L Siegemund | 6 | 6 | ||||||||||||||||||||
| 7 | D Radanović | 66 | 5r | Q | T Korpatsch | 3 | 4 | ||||||||||||||||||||
| T Lukas | 78 | 6 | T Lukas | 0 | 0r | ||||||||||||||||||||||
 J Grabher | 6 | 6 | J Grabher | 6 | 3 | ||||||||||||||||||||||
| WC | A Lex | 4 | 3 | J Grabher | 3 | 3 | |||||||||||||||||||||
| Q | T Korpatsch | 2 | 6 | 6 | Q | T Korpatsch | 6 | 6 | |||||||||||||||||||
| B Haas | 6 | 1 | 3 | Q | T Korpatsch | 6 | 6 | ||||||||||||||||||||
| T Martincová | 4 | 0 | 2 | A Lottner | 4 | 0 | |||||||||||||||||||||
| 2 | A Lottner | 6 | 6 | ||||||||||||||||||||||||
Sanaz Marand and Florencia Molinero were the defending champions, but both players chose not to participate.
Laura Siegemund and Renata Voráčová were the defending champions, but both players chose not to participate.
Zhang Shuai was the defending champion, but chose not to participate.
Natela Dzalamidze and Veronika Kudermetova were the defending champions, but decided not to participate.
Maia Lumsden was the defending champion, but lost to Yanina Wickmayer in the quarterfinals.
Alison Van Uytvanck was the defending champion and successfully defended her title, defeating Markéta Vondroušová in the final, 1–6, 7–5, 6–2.
Anastasija Sevastova was the defending champion, but lost in the second round to Patricia Maria Țig.
Kristina Mladenovic and Katarzyna Piter were the champions the last time the tournament was held in 2013, but chose not to participate this year.
Olga Ianchuk was the defending champion, but chose not to participate.
Timea Bacsinszky was the defending champion, but chose not to participate.
World No. 1 Ashleigh Barty defeated Aryna Sabalenka in the final, 3–6, 6–0, 6–3 to win the women's singles tennis title at the 2021 edition of the Stuttgart Open.
Tamara Zidanšek was the two-time defending champion, having won the last edition in 2019, however she was unable to defend her title as she was still competing at the 2021 French Open, reaching the semi-final of the Grand Slam.
Simona Halep was the defending champion, having won the previous edition in 2013, but chose not to participate.
Maja Chwalińska was the defending champion but chose not to participate.
Irina Bara and Rebeka Masarova were the defending champions but lost in the semifinals to Aliona Bolsova and Andrea Gámiz.
This was the first edition of the tournament since 1987.
Elisabetta Cocciaretto was the defending champion but chose not to participate.
This was the first edition of the women's event.
This was the first edition of the women's event.
Clara Tauson is the defending champion, but chose not to participate.