| Doubles | |
|---|---|
| 2018 Morelos Open | |
| Champions |  Roberto Maytín  Fernando Romboli |
| Runners-up |  Evan King Nathan Pasha |
| Final score | 7–5, 6–3 |
Austin Krajicek and Jackson Withrow were the defending champions but only Krajicek chose to defend his title, partnering Matt Reid. Krajicek withdrew before the tournament began due to injury.
Roberto Maytín and Fernando Romboli won the title after defeating Evan King and Nathan Pasha 7–5, 6–3 in the final.
Marcelo Arévalo / 
Miguel Ángel Reyes-Varela (quarterfinals) Austin Krajicek / 
Matt Reid (withdrew)
Franco Agamenone / 
Sergio Galdós (quarterfinals)
Ruan Roelofse / Max Schnur (semifinals)| First round | Quarterfinals | Semifinals | Final | ||||||||||||||||||||||||
| 1 | M Arévalo MÁ Reyes-Varela | 6 | 6 | ||||||||||||||||||||||||
 R Gonzales H Reese | 3 | 4 | 1 | M Arévalo MÁ Reyes-Varela | 3 | 65 | |||||||||||||||||||||
| E King N Pasha | 712 | 6 | E King N Pasha | 6 | 77 | ||||||||||||||||||||||
| WC | L Patiño  R Quiroz | 610 | 4 | E King N Pasha | 78 | 79 | |||||||||||||||||||||
| 4 | R Roelofse M Schnur | 6 | 6 | 4 | R Roelofse M Schnur | 66 | 67 | ||||||||||||||||||||
 S Diez  R Ortega Olmedo | 4 | 4 | 4 | R Roelofse M Schnur | 710 | 78 | |||||||||||||||||||||
D Novikov  A Pavić | 6 | 6 | D Novikov A Pavić | 68 | 66 | ||||||||||||||||||||||
| WC | G López Villaseñor M Sánchez | 3 | 4 | E King N Pasha | 5 | 3 | |||||||||||||||||||||
 B Arias F Zeballos | 3 | 77 | [10] | R Maytín F Romboli | 7 | 6 | |||||||||||||||||||||
 P Krstin  D Popko | 6 | 65 | [6] | B Arias F Zeballos | 77 | 6 | |||||||||||||||||||||
| WC | Isaac Arturo Arévalo T Hank | 1 | 0 | 3 | F Agamenone S Galdós | 65 | 4 | ||||||||||||||||||||
| 3 | F Agamenone S Galdós | 6 | 6 | B Arias F Zeballos | 3 | 4 | |||||||||||||||||||||
| R Maytín F Romboli | 6 | 6 | R Maytín F Romboli | 6 | 6 | ||||||||||||||||||||||
 B Saraiva  S Verbeek | 3 | 3 | R Maytín F Romboli | 66 | 6 | [10] | |||||||||||||||||||||
LD Martínez  R Statham | w/o | LD Martínez R Statham | 78 | 4 | [8] | ||||||||||||||||||||||
| Alt |  DE Galán A González | ||||||||||||||||||||||||||
Juan Martín del Potro was the defending champion, but chose to compete in Dubai instead.
Kevin Anderson won the title after defeating Marinko Matosevic 6–4, 7–6(7–2) in the final.
Austin Krajicek and John Peers were the defending champions, but Peers chose not to compete.
Krajicek paired with Mitchell Krueger but lost in the semifinals to eventual finalists Bradley Klahn and Michael Venus.
Frank Dancevic and Peter Polansky won the title 7–5, 6–3.
Austin Krajicek and Tennys Sandgren were the defending champions. but decided not to compete.
Austin Krajicek and Rhyne Williams were the defending champions, but they did not compete.
Alexander Peya and Bruno Soares were the defending champions, but lost in the opening round to Leonardo Mayer and João Sousa.
Jean-Julien Rojer and Horia Tecău won the title, defeating Kevin Anderson and Jérémy Chardy in the final, 6–4, 6–2.
Paolo Lorenzi was the defending champion, but lost in the semifinals.
Roberto Bautista Agut was the defending champion, but lost in the second round to Nicolas Mahut.
Austin Krajicek and John-Patrick Smith were the defending champions, but Smith did not participate this year. Krajicek partnered with Nicholas Monroe, but lost in the quarterfinals to Yuki Bhambri and Michael Venus.
Andy Murray was the defending champion but chose not to participate this year.
Tomáš Berdych won the title, defeating Guillermo García-López in the final, 6–3, 7–6(9–7).
Lu Yen-hsun and Jonathan Marray were the defending champions, but Lu chose not to compete this year and Marray chose to compete in Brisbane instead.
Oliver Marach and Fabrice Martin won the title, defeating Austin Krajicek and Benoît Paire in the final, 6–3, 7–5.
This was the first edition of the tournament.
Evan King and Denis Kudla were the defending champions but only King chose to defend his title, partnering Christopher Eubanks. King successfully defended his title.
Matt Reid and John-Patrick Smith were the defending champions but chose not to defend their title.
Ken and Neal Skupski were the defending champions but lost in the semifinals to Frederik Nielsen and Joe Salisbury.
Jamie Murray and Bruno Soares were the defending champions, but lost in the first round to Robert Lindstedt and Frances Tiafoe.
Barbora Krejčíková and Rajeev Ram were the defending champions, but Ram chose not to participate. Krejčíková played alongside Nikola Mektić, and successfully defended the title, defeating Bethanie Mattek-Sands and Jamie Murray in the final 5–7, 6–4, [10–1].
Marcel Granollers and Sergiy Stakhovsky were the reigning champions from when the tournament was last held in 2019, but chose not to defend their title.
Austin Krajicek and Franko Škugor were the defending champions, but Krajicek chose to compete at the Summer Olympics and Škugor chose not to defend his title.
Łukasz Kubot and Marcelo Melo were the reigning champions from when the tournament was last held in 2019, but lost in the semifinals to Ivan Dodig and Austin Krajicek.
Thanasi Kokkinakis and Nick Kyrgios defeated Matthew Ebden and Max Purcell in the final, 7–5, 6–4 to win the men's doubles title at the 2022 Australian Open. They became the first all-Australian pair to win the title since Todd Woodbridge and Mark Woodforde in 1997, and the first wildcard champions in the Open Era. The final marked the first all-Australian men's doubles final at the Australian Open since 1980.