Maxime Authom and Ruben Bemelmans are the defending champions, having won the event in 2012, but lost in the first round.
Christopher Kas and Dick Norman were the defending champion, but Norman chose to compete.
Kas chose to compete with Paul Hanley, but they lost in the first round to Niels Desein and Tim Pütz.
Jürgen Melzer and Philipp Petzschner were the defending champions, but decided not to compete.
Jamie Murray and John Peers were the defending champions, but decided not to compete.
Édouard Roger-Vasselin and Igor Sijsling were the defending champions, but chose not to participate.
Vasek Pospisil and Jack Sock won the title, defeating Steve Johnson and Sam Querrey in the final, 6–3, 5–7, [10–5].
Illya Marchenko and Sergiy Stakhovsky were the defending tennis doubles champions, but neither player chose to participate.
Henri Kontinen and Andreas Siljeström were the defending champions, but they did not compete that year.
Ken Skupski and Neal Skupski won the title, defeating Norbert Gombos and Adam Pavlásek in the final, 6–3, 7–6(7–3).
Ryan Agar and Sebastian Bader were the defending champions, but they did not participate this year.
Daniel Nestor and Édouard Roger-Vasselin were the defending champions, but chose not to participate together. Nestor played alongside Aisam-ul-Haq Qureshi, but lost in the first round to Rohan Bopanna and Donald Young. Roger-Vasselin teamed up with Steve Johnson, but lost in the first round to Jamie Murray and Bruno Soares.
Treat Huey and Frederik Nielsen were the defending champions but chose to defend their title with different partners. Huey partnered Robert Lindstedt but lost in the final to James Cerretani and Neal Skupski. Nielsen partnered Andreas Siljeström but lost in the semifinals to Huey and Lindstedt.
Nikola Mektić and Franko Škugor were the defending champions but chose not to defend their title.
Roman Jebavý and Jiří Veselý were the defending champions, but Veselý chose not to participate this year. Jebavý played alongside Florin Mergea, but lost in the first round to Dominic Inglot and Robert Lindstedt.
Marcus Daniell and Aisam-ul-Haq Qureshi were the defending champions but only Qureshi chose to defend his title, partnering Divij Sharan. Qureshi lost in the quarterfinals to Alex Bolt and Lleyton Hewitt.
Bob and Mike Bryan were the defending champions, but Bob was unable to compete due to an injury. Mike played alongside James Cerretani, but lost in the first round to Scott Clayton and Joe Salisbury.
Aisam-ul-Haq Qureshi and Rajeev Ram were the defending champions but Ram chose not to participate and Qureshi chose to compete in Båstad instead.
James Cerretani and Neal Skupski were the defending champions but only Skupski chose to defend his title, partnering Luke Bambridge. Skupski successfully defended his title.
Rohan Bopanna and Pablo Cuevas were the defending champions, but Bopanna chose to compete in Basel and Cuevas chose to compete in Lima instead.
Luke Bambridge and Neal Skupski were the defending champions but only Bambridge chose to defend his title, partnering Ben McLachlan. Bambridge lost in the quarterfinals to Treat Huey and Adil Shamasdin.
Evan King and Hunter Reese were the defending champions but chose not to defend their title.
Ena Shibahara and Wesley Koolhof defeated Ulrikke Eikeri and Joran Vliegen in the final, 7–6(7–5), 6–2 to win the mixed doubles tennis title at the 2022 French Open.
Neal Skupski 
John-Patrick Smith 
Ruben Bemelmans 
Jonathan Eysseric 
