| Singles | |
|---|---|
| 2021 Biella Challenger Indoor II | |
| Champion |  Kwon Soon-woo |
| Runner-up |  Lorenzo Musetti |
| Final score | 6–2, 6–3 |
This was the second of seven editions of the tournament in the 2021 tennis season. [1] Illya Marchenko was the defending champion but lost in the quarterfinals to Andreas Seppi.
Kwon Soon-woo won the title after defeating Lorenzo Musetti 6–2, 6–3 in the final.
Alejandro Davidovich Fokina (second round)
Sebastian Korda (first round) Kwon Soon-woo (champion) Andreas Seppi (semifinals)
Kamil Majchrzak (second round)
Antoine Hoang (first round) Lorenzo Musetti (final)
Evgeny Donskoy (semifinals)| Semifinals | Final | ||||||||||||
| 8 | Evgeny Donskoy | 3 | 77 | 1 | |||||||||
| 3 | Kwon Soon-woo | 6 | 64 | 6 | |||||||||
| 3 | Kwon Soon-woo | 6 | 6 | ||||||||||
| 7 | Lorenzo Musetti | 2 | 3 | ||||||||||
| 4 | Andreas Seppi | 6 | 3 | 4 | |||||||||
| 7 | Lorenzo Musetti | 3 | 6 | 6 | |||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | A Davidovich Fokina | 6 | 6 | ||||||||||||||||||||||||
 S Diez | 3 | 0 | 1 | A Davidovich Fokina | 62 | 4 | |||||||||||||||||||||
| F Gaio | 6 | 6 | F Gaio | 77 | 6 | ||||||||||||||||||||||
| LL |  H Moriya | 3 | 1 | F Gaio | 3 | 2 | |||||||||||||||||||||
| Q | C Lestienne | 5 | 712 | 77 | 8 | E Donskoy | 6 | 6 | |||||||||||||||||||
| WC | L Nardi | 7 | 610 | 60 | Q | C Lestienne | 4 | 2 | |||||||||||||||||||
 M Safwat | 3 | 4 | 8 | E Donskoy | 6 | 6 | |||||||||||||||||||||
| 8 | E Donskoy | 6 | 6 | 8 | E Donskoy | 3 | 77 | 1 | |||||||||||||||||||
| 3 | S-w Kwon | 6 | 6 | 3 | S-w Kwon | 6 | 64 | 6 | |||||||||||||||||||
 J Jung | 3 | 4 | 3 | S-w Kwon | 6 | 6 | |||||||||||||||||||||
| R Marcora | 77 | 6 | R Marcora | 2 | 2 | ||||||||||||||||||||||
 H Laaksonen | 64 | 1 | 3 | S-w Kwon | 6 | 6 | |||||||||||||||||||||
| A Giannessi | 1 | 4 |  Y Maden | 2 | 1 | ||||||||||||||||||||||
| T Fabbiano | 6 | 6 | T Fabbiano | 63 | 1 | ||||||||||||||||||||||
| Y Maden | 6 | 6 | Y Maden | 77 | 6 | ||||||||||||||||||||||
| 6 | A Hoang | 0 | 2 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 5 | K Majchrzak | 77 | 6 | ||||||||||||||||||||||||
 B Rola | 65 | 4 | 5 | K Majchrzak | 6 | 4 | 1 | ||||||||||||||||||||
| SE |  I Marchenko | 77 | 4 | 6 | SE | I Marchenko | 1 | 6 | 6 | ||||||||||||||||||
| WC | G Zeppieri | 61 | 6 | 3 | SE | I Marchenko | 4 | 5 | |||||||||||||||||||
| B Zapata Miralles | 65 | 4 | 4 | A Seppi | 6 | 7 | |||||||||||||||||||||
 M Kližan | 77 | 6 | M Kližan | 68 | 3 | ||||||||||||||||||||||
| Q | M Viola | 2 | 6 | 5 | 4 | A Seppi | 710 | 6 | |||||||||||||||||||
| 4 | A Seppi | 6 | 4 | 7 | 4 | A Seppi | 6 | 3 | 4 | ||||||||||||||||||
| 7 | L Musetti | 7 | 6 | 7 | L Musetti | 3 | 6 | 6 | |||||||||||||||||||
| WC | S Napolitano | 5 | 3 | 7 | L Musetti | 6 | 6 | ||||||||||||||||||||
| Q | B Kavčič | 3 | 2 | Alt | L Lacko | 4 | 3 | ||||||||||||||||||||
| Alt | L Lacko | 6 | 6 | 7 | L Musetti | 6 | 6 | ||||||||||||||||||||
| Q | R Brancaccio | 6 | 3 | 4 | Alt |  E Gulbis | 2 | 4 | |||||||||||||||||||
| Alt | E Gulbis | 4 | 6 | 6 | Alt | E Gulbis | 6 | 6 | |||||||||||||||||||
 D Popko | 6 | 6 | D Popko | 1 | 4 | ||||||||||||||||||||||
| 2 | S Korda | 4 | 3 | ||||||||||||||||||||||||
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