| Singles | |
|---|---|
| 2021 Biella Challenger VI | |
| Champion |  Thanasi Kokkinakis |
| Runner-up |  Enzo Couacaud |
| Score | 6–3, 6–4 |
Juan Pablo Varillas was the defending champion [1] but chose not to defend his title.
Thanasi Kokkinakis won the title after defeating Enzo Couacaud 6–3, 6–4 in the final.
Paolo Lorenzi (first round)
Zhang Zhizhen (semifinals) Enzo Couacaud (final) Alexandre Müller (quarterfinals)
Dmitry Popko (first round) Alex Bolt (first round)
João Menezes (first round)
Bjorn Fratangelo (quarterfinals)| Semifinals | Final | ||||||||||||
| Q |  Tomás Martín Etcheverry | 1 | 7 | 4 | |||||||||
| 3 | Enzo Couacaud | 6 | 5 | 6 | |||||||||
| 3 | Enzo Couacaud | 3 | 4 | ||||||||||
| Thanasi Kokkinakis | 6 | 6 | |||||||||||
| Thanasi Kokkinakis | 6 | 4 | 6 | ||||||||||
| 2 | Zhang Zhizhen | 2 | 6 | 3 | |||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1/WC | P Lorenzi | 0 | 65 | ||||||||||||||||||||||||
| Q | TM Etcheverry | 6 | 77 | Q | TM Etcheverry | 4 | 77 | 4 | |||||||||||||||||||
| F Meligeni Alves | 6 | 6 | F Meligeni Alves | 6 | 60 | 0r | |||||||||||||||||||||
 J Clarke | 3 | 3 | Q | TM Etcheverry | 6 | 6 | |||||||||||||||||||||
| T Lamasine | 5 | 6 | 1 | F Mena | 3 | 2 | |||||||||||||||||||||
 D Kuzmanov | 7 | 4 | 6 | D Kuzmanov | 2 | 78 | 1 | ||||||||||||||||||||
| F Mena | 6 | 6 | F Mena | 6 | 66 | 6 | |||||||||||||||||||||
| 7 | J Menezes | 3 | 4 | Q | TM Etcheverry | 1 | 7 | 4 | |||||||||||||||||||
| 3 | E Couacaud | 6 | 6 | 3 | E Couacaud | 6 | 5 | 6 | |||||||||||||||||||
 T Kamke | 4 | 2 | 3 | E Couacaud | 77 | 5 | 6 | ||||||||||||||||||||
| Q |  T van Rijthoven | 6 | 6 | Q | T van Rijthoven | 64 | 7 | 2 | |||||||||||||||||||
| Q | Omar Giacalone | 2 | 2 | 3 | E Couacaud | 6 | 65 | 6 | |||||||||||||||||||
| A Collarini | 6 | 6 | 8 | B Fratangelo | 1 | 77 | 3 | ||||||||||||||||||||
 M Copil | 2 | 1 | A Collarini | 6 | 62 | 0r | |||||||||||||||||||||
 C İlkel | 2 | 4 | 8 | B Fratangelo | 1 | 77 | 3 | ||||||||||||||||||||
| 8 | B Fratangelo | 6 | 6 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 6 | A Bolt | 79 | 1 | 3 | |||||||||||||||||||||||
| WC | S Napolitano | 67 | 6 | 6 | WC | S Napolitano | 3 | 4 | |||||||||||||||||||
 D Istomin | 6 | 2 | 3 | T Kokkinakis | 6 | 6 | |||||||||||||||||||||
| T Kokkinakis | 3 | 6 | 6 | T Kokkinakis | 6 | 77 | |||||||||||||||||||||
 R Cid Subervi | 5 | 3 | 4 | A Müller | 4 | 61 | |||||||||||||||||||||
| Q | R Bonadio | 7 | 6 | Q | R Bonadio | 0 | 64 | ||||||||||||||||||||
| M Viola | 6 | 3 | 1 | 4 | A Müller | 6 | 77 | ||||||||||||||||||||
| 4 | A Müller | 4 | 6 | 6 | T Kokkinakis | 6 | 4 | 6 | |||||||||||||||||||
| 5 | D Popko | 2 | 6 | 62 | 2 | Zh Zhang | 2 | 6 | 3 | ||||||||||||||||||
| T-S Kwiatkowski | 6 | 1 | 77 | T-S Kwiatkowski | 6 | 77 | |||||||||||||||||||||
 E Benchetrit | 4 | 4 | U Blanch | 4 | 63 | ||||||||||||||||||||||
| U Blanch | 6 | 6 | T-S Kwiatkowski | 4 | 65 | ||||||||||||||||||||||
| M Krueger | 4 | 3 | 2 | Zh Zhang | 6 | 77 | |||||||||||||||||||||
| WC | F Cobolli | 6 | 6 | WC | F Cobolli | 6 | 4 | 2 | |||||||||||||||||||
 B Gojo | 3 | 6 | 2 | 2 | Zh Zhang | 4 | 6 | 6 | |||||||||||||||||||
| 2 | Zh Zhang | 6 | 4 | 6 | |||||||||||||||||||||||
Andrew Harris and Nick Kyrgios were the defending champions, but Harris was no longer eligible to compete in junior tennis, and thus could not defend his title.
Gaël Monfils was the defending champion, but lost to Richard Gasquet in the semifinals.
Gasquet went on to win the title, defeating Jerzy Janowicz in the final, 3–0, ret.
David Goffin was the defending champion but chose not to participate this year.
Yasutaka Uchiyama was the defending champion but chose not to defend his title.
Bradley Klahn was the defending champion but chose not to defend his title.
Peter Polansky was the defending champion but lost in the semifinals to Yasutaka Uchiyama.
Lorenzo Giustino was the defending champion but lost in the first round to Timofey Skatov.
Carlos Taberner was the defending champion but chose not to defend his title.
Casper Ruud defeated Hugo Gaston in the final, 6–3, 6–2, to win the men's singles tennis title at the 2021 Swiss Open.
Tommy Robredo was the defending champion but chose not to defend his title.
Juan Pablo Varillas was the defending champion but lost in the quarterfinals to Marcelo Tomás Barrios Vera.
João Sousa defeated Emil Ruusuvuori in the final, 7–6(11–9), 4–6, 6–1 to win the singles title at the 2022 Tata Open Maharashtra. Sousa saved three match points against Elias Ymer in the semifinals. This was his first title since 2018.
James Duckworth was the defending champion but chose not to defend his title.
Zizou Bergs was the defending champion but lost in the quarterfinals to Quentin Halys.
Kacper Żuk was the defending champion but lost in the quarterfinals to Christopher O'Connell.
Jason Kubler was the defending champion but chose not to defend his title.
Tommy Paul was the defending champion but chose not to defend his title.
Christopher O'Connell was the defending champion but chose not to defend his title.
Christopher Eubanks was the defending champion but lost in the final to Ben Shelton.
Maxime Cressy was the defending champion but chose not to defend his title.