| Singles | |
|---|---|
| 2021 Biella Challenger V | |
| Champion |  Juan Pablo Varillas |
| Runner-up |  Guido Andreozzi |
| Score | 6–3, 6–1 |
Daniel Masur was the defending champion [1] but chose not to defend his title.
Juan Pablo Varillas won the title after defeating Guido Andreozzi 6–3, 6–1 in the final.
Pedro Sousa (first round)
Hugo Dellien (second round)
Mackenzie McDonald (second round)
Cedrik-Marcel Stebe (first round)
Federico Gaio (quarterfinals)
Hugo Gaston (first round) Juan Pablo Varillas (champion)
Go Soeda (first round)| Semifinals | Final | ||||||||||||
| 7 | Juan Pablo Varillas | 6 | 2 | 6 | |||||||||
| Alexandre Müller | 2 | 6 | 2 | ||||||||||
| 7 | Juan Pablo Varillas | 6 | 6 | ||||||||||
| Q | Guido Andreozzi | 3 | 1 | ||||||||||
| Q | Guido Andreozzi | 7 | 6 | ||||||||||
| Alt | Andrea Collarini | 5 | 2 | ||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | P Sousa | 63 | 4 | ||||||||||||||||||||||||
 J Menezes | 77 | 6 | J Menezes | 7 | 2 | 6 | |||||||||||||||||||||
| WC |  H Međedović | 7 | 77 | WC | H Međedović | 5 | 6 | 4 | |||||||||||||||||||
 R Bemelmans | 5 | 64 | J Menezes | 4 | 3 | ||||||||||||||||||||||
| LL |  D Kuzmanov | 6 | 1 | 6 | 7 | JP Varillas | 6 | 6 | |||||||||||||||||||
| L Giustino | 3 | 6 | 3 | LL | D Kuzmanov | 1 | 7 | 60 | |||||||||||||||||||
| A Giannessi | 4 | 5 | 7 | JP Varillas | 6 | 5 | 77 | ||||||||||||||||||||
| 7 | JP Varillas | 6 | 7 | 7 | JP Varillas | 6 | 2 | 6 | |||||||||||||||||||
| 3 | M McDonald | 3 | 6 | 6 | A Müller | 2 | 6 | 2 | |||||||||||||||||||
| JM Cerúndolo | 6 | 4 | 3 | 3 | M McDonald | 77 | 2 | 4 | |||||||||||||||||||
| WC | L Vanni | 67 | 0 | L Mayer | 60 | 6 | 6 | ||||||||||||||||||||
| L Mayer | 79 | 6 | L Mayer | 3 | 4 | ||||||||||||||||||||||
 Zh Zhang | 4 | 6 | 6 | A Müller | 6 | 6 | |||||||||||||||||||||
| Q | F Meligeni Alves | 6 | 4 | 4 | Zh Zhang | 3 | 77 | 5 | |||||||||||||||||||
| A Müller | 1 | 6 | 6 | A Müller | 6 | 64 | 7 | ||||||||||||||||||||
| 6 | H Gaston | 6 | 3 | 3 | |||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 8 | G Soeda | 2 | 1 | ||||||||||||||||||||||||
| Q | M Marterer | 6 | 6 | Q | M Marterer | 3 | 3 | ||||||||||||||||||||
| Alt |  J Clarke | 7 | 6 | Alt | J Clarke | 6 | 6 | ||||||||||||||||||||
| Q |  V Galović | 5 | 2 | Alt | J Clarke | 6 | 3 | 5 | |||||||||||||||||||
| Q | G Andreozzi | 6 | 7 | Q | G Andreozzi | 3 | 6 | 7 | |||||||||||||||||||
| K Coppejans | 2 | 5 | Q | G Andreozzi | 3 | 6 | 6 | ||||||||||||||||||||
| LL |  MT Barrios Vera | 6 | 6 | LL | MT Barrios Vera | 6 | 3 | 3 | |||||||||||||||||||
| 4 | C-M Stebe | 2 | 4 | Q | G Andreozzi | 7 | 6 | ||||||||||||||||||||
| 5 | F Gaio | 63 | 77 | 6 | Alt | A Collarini | 5 | 2 | |||||||||||||||||||
| P Lorenzi | 77 | 64 | 2 | 5 | F Gaio | 6 | 6 | ||||||||||||||||||||
 F Horanský | 2 | 4 | J Domingues | 4 | 3 | ||||||||||||||||||||||
| J Domingues | 6 | 6 | 5 | F Gaio | 6 | 4 | 1 | ||||||||||||||||||||
| Alt | A Collarini | 6 | 6 | Alt | A Collarini | 4 | 6 | 6 | |||||||||||||||||||
 A Bolt | 2 | 2 | Alt | A Collarini | 6 | 7 | |||||||||||||||||||||
| WC | S Napolitano | 0 | 7 | 1 | 2 | H Dellien | 1 | 5 | |||||||||||||||||||
| 2 | H Dellien | 6 | 5 | 6 | |||||||||||||||||||||||
Cristian Garín was the defending champion but chose not to defend his title.
Guido Andreozzi was the defending champion but chose not to defend his title.
Guido Pella was the defending champion but chose not to defend his title.
Fabio Fognini was the champion in 2014, when the event was last held, but chose to compete in Dubai instead.
Cristian Garín was the defending champion, but chose not to defend his title.
Cristian Garín defeated Facundo Bagnis in the final, 6–4, 6–7(3–7), 7–5 to capture the men's singles tennis title at the 2021 Chile Open.
Henri Laaksonen was the defending champion but chose not to defend his title.
Andrea Pellegrino was the defending champion but lost in the quarterfinals to Flavio Cobolli.
Oscar Otte was the defending champion but retired in the quarterfinals to Elias Ymer.
Andrey Rublev was the defending champion, but chose to not defend his title as he and other Russian Olympic athletes were sent to Yuzhno-Sakhalinsk for training sessions.
Bernabé Zapata Miralles was the defending champion but chose not to defend his title.
Daniel Elahi Galán was the defending champion but chose not to defend his title.
Sebastián Báez was the defending champion but lost in the final to Juan Pablo Varillas.
Sumit Nagal was the defending champion but chose not to defend his title.
Hugo Dellien was the defending champion but lost in the quarterfinals to Juan Manuel Cerúndolo.
Jaume Munar was the defending champion but lost in the semifinals to Juan Ignacio Londero.
Albert Ramos Viñolas defeated Alejandro Tabilo in the final, 4–6, 6–3, 6–4 to win the singles title at the 2022 Córdoba Open.
Sebastián Báez was the defending champion but chose not to defend his title.
Francisco Cerúndolo was the defending champion but chose not to defend his title.
Defending champion Casper Ruud defeated Matteo Berrettini in the final, 4–6, 7–6(7–4), 6–2 to win the singles tennis title at the 2022 Swiss Open Gstaad.