| Singles | |
|---|---|
| 2021 Cary Challenger II | |
| Champion |  Mitchell Krueger |
| Runner-up | Bjorn Fratangelo |
| Score | 6–4, 6–3 |
Mitchell Krueger was the defending champion [1] and successfully defended his title.
Krueger won the title after defeating Bjorn Fratangelo 6–4, 6–3 in the final.
Tennys Sandgren (first round, defaulted) Denis Kudla (semifinals)
Salvatore Caruso (second round)
Alex Bolt (first round)
Jason Jung (first round) Mitchell Krueger (champion) Michael Mmoh (quarterfinals) Bjorn Fratangelo (final)| Semifinals | Final | ||||||||||||
| 8 | Bjorn Fratangelo | 62 | 77 | 6 | |||||||||
| Aleksandar Vukic | 77 | 64 | 2 | ||||||||||
| 8 | Bjorn Fratangelo | 4 | 3 | ||||||||||
| 6 | Mitchell Krueger | 6 | 6 | ||||||||||
| 6 | Mitchell Krueger | 6 | 3 | 77 | |||||||||
| 2 | Denis Kudla | 2 | 6 | 62 | |||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | T Sandgren | 1d | |||||||||||||||||||||||||
| C Eubanks | 0 | C Eubanks | 6 | 66 | 4 | ||||||||||||||||||||||
 R Peniston | 6 | 6 | R Peniston | 4 | 78 | 6 | |||||||||||||||||||||
 P Polansky | 3 | 2 | R Peniston | 3 | 5 | ||||||||||||||||||||||
| U Blanch | 5 | 0 | 8 | B Fratangelo | 6 | 7 | |||||||||||||||||||||
| Q |  S Mochizuki | 7 | 6 | Q | S Mochizuki | 2 | 1 | ||||||||||||||||||||
| Q | A Sarkissian | 2 | 7 | 1 | 8 | B Fratangelo | 6 | 6 | |||||||||||||||||||
| 8 | B Fratangelo | 6 | 5 | 6 | 8 | B Fratangelo | 62 | 77 | 6 | ||||||||||||||||||
| 3 | S Caruso | 6 | 6 | A Vukic | 77 | 64 | 2 | ||||||||||||||||||||
| C Harrison | 3 | 3 | 3 | S Caruso | 2 | 4 | |||||||||||||||||||||
| Mi Redlicki | 4 | 4 | A Vukic | 6 | 6 | ||||||||||||||||||||||
| A Vukic | 6 | 6 | A Vukic | 3 | 6 | 6 | |||||||||||||||||||||
| S Kozlov | 5 | 0r | WC | Z Svajda | 6 | 2 | 3 | ||||||||||||||||||||
| WC | Z Svajda | 7 | 2 | WC | Z Svajda | 7 | 6 | ||||||||||||||||||||
| Q | R Hijikata | 6 | 6 | Q | R Hijikata | 5 | 3 | ||||||||||||||||||||
| 5 | J Jung | 4 | 4 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 6 | M Krueger | 6 | 6 | ||||||||||||||||||||||||
| J Kubler | 3 | 2 | 6 | M Krueger | 6 | 6 | |||||||||||||||||||||
 N Mejía | 4 | 4 | D Kelly | 4 | 4 | ||||||||||||||||||||||
| D Kelly | 6 | 6 | 6 | M Krueger | 6 | 6 | |||||||||||||||||||||
| JC Aragone | 3 | 6 | 6 | M Purcell | 3 | 2 | |||||||||||||||||||||
 M Torpegaard | 6 | 2 | 3 | JC Aragone | 2 | 2 | |||||||||||||||||||||
| M Purcell | 6 | 6 | M Purcell | 6 | 6 | ||||||||||||||||||||||
| 4 | A Bolt | 4 | 1 | 6 | M Krueger | 6 | 3 | 77 | |||||||||||||||||||
| 7 | M Mmoh | 6 | 6 | 2 | D Kudla | 2 | 6 | 62 | |||||||||||||||||||
| N Rubin | 1 | 3 | 7 | M Mmoh | 6 | 6 | |||||||||||||||||||||
| WC |  Luca Stäheli | 3 | 7 | 1 |  M Sasikumar | 4 | 4 | ||||||||||||||||||||
| M Sasikumar | 6 | 5 | 6 | 7 | M Mmoh | 63 | 3 | ||||||||||||||||||||
| Q | A Kovacevic | 77 | 6 | 2 | D Kudla | 77 | 6 | ||||||||||||||||||||
| WC | Garrett Johns | 63 | 4 | Q | A Kovacevic | 77 | 2 | 3 | |||||||||||||||||||
| D Young | 63 | 6 | 2 | 2 | D Kudla | 62 | 6 | 6 | |||||||||||||||||||
| 2 | D Kudla | 77 | 4 | 6 | |||||||||||||||||||||||
Bjorn Fratangelo was the defending champion, but was not eligible to participate.
Kimmer Coppejans won this event, defeating 5th-seed Filip Peliwo 6–1, 6–4 in the final.
Austin Krajicek and Tennys Sandgren were the defending champions. but decided not to compete.
John Millman was the defending champion but chose not to defend his title.
Bjorn Fratangelo was the defending champion but chose not to defend his title.
Kei Nishikori was the defending champion but chose not to defend his title.
Tommy Paul won the title after defeating Tennys Sandgren 6–3, 6–4 in the final.
Pedro Sousa was the defending champion but withdrew before the tournament began due to injury.
Tommy Robredo was the defending champion but retired in the first round against Maxime Janvier.
Evgeny Karlovskiy was the defending champion but lost in the first round to Stefan Kozlov.
Steve Johnson was the defending champion, but lost in the first round to Christopher Eubanks.
Thanasi Kokkinakis was the defending champion but lost in the second round to Egor Gerasimov.
James Duckworth was the defending champion but chose not to defend his title.
Bjorn Fratangelo was the defending champion but chose not to defend his title.
Mikael Torpegaard was the defending champion but lost in the first round to Lucas Catarina.
Denis Kudla was the defending champion but chose not to defend his title.
Vasek Pospisil was the defending champion but lost in the first round to Emilio Nava.
Michael Mmoh was the defending champion but lost in the semifinals to Daniel Altmaier.
Marc Polmans was the defending champion but chose not to participate.
Cameron Norrie defeated Reilly Opelka in the final, 7–6(7–1), 7–6(7–4) to win the singles title at the 2022 Delray Beach Open.
Reilly Opelka defeated John Isner in the final, 6–3, 7–6(9–7), to win the singles tennis title at the 2022 U.S. Men's Clay Court Championships. It marked Opelka's fourth career Association of Tennis Professionals (ATP) singles title and his first on clay. With Opelka's height at 6 ft 11 in (211 cm) and Isner's at 6 ft 10 in (208 cm), the combined heights of both players made the final the tallest one ever contended during the Open Era. At the age of 36, Isner was also playing to become the oldest champion at the tournament in the Open Era.