| Singles | |
|---|---|
| 2021 Garden Open | |
| Champion |  Andrea Pellegrino |
| Runner-up |  Hugo Gaston |
| Score | 3–6, 6–2, 6–1 |
Henri Laaksonen was the defending champion [1] but chose not to defend his title.
Andrea Pellegrino won the title after defeating Hugo Gaston 3–6, 6–2, 6–1 in the final.
Grégoire Barrère (first round)
Hugo Dellien (first round) Paolo Lorenzi (second round)
Sebastian Ofner (quarterfinals) Hugo Gaston (final)
Juan Pablo Varillas (semifinals) Lorenzo Giustino (quarterfinals)
Steven Diez (first round)| Semifinals | Final | ||||||||||||
| 6 | Juan Pablo Varillas | 4 | 5 | ||||||||||
| 5 | Hugo Gaston | 6 | 7 | ||||||||||
| 5 | Hugo Gaston | 6 | 2 | 1 | |||||||||
| WC | Andrea Pellegrino | 3 | 6 | 6 | |||||||||
| WC | Andrea Pellegrino | 3 | 6 | 6 | |||||||||
| Q |  Vít Kopřiva | 6 | 1 | 1 | |||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | G Barrère | 64 | 4 | ||||||||||||||||||||||||
 G Andreozzi | 77 | 6 | G Andreozzi | 5 | 78 | 2 | |||||||||||||||||||||
| E Couacaud | 3 | 3 |  E Ymer | 7 | 66 | 6 | |||||||||||||||||||||
| E Ymer | 6 | 6 | E Ymer | 4 | 3 | ||||||||||||||||||||||
| Alt |  B Gojo | 2 | 3 | 6 | JP Varillas | 6 | 6 | ||||||||||||||||||||
| R Marcora | 6 | 6 | R Marcora | 3 | 0 | ||||||||||||||||||||||
| Alt | A Collarini | 2 | 6 | 2 | 6 | JP Varillas | 6 | 6 | |||||||||||||||||||
| 6 | JP Varillas | 6 | 3 | 6 | 6 | JP Varillas | 4 | 5 | |||||||||||||||||||
| 3 | P Lorenzi | 77 | 2 | 6 | 5 | H Gaston | 6 | 7 | |||||||||||||||||||
 Y Maden | 64 | 6 | 3 | 3 | P Lorenzi | 6 | 1 | 5 | |||||||||||||||||||
 A Bolt | 3 | 4 | Q | T Lamasine | 4 | 6 | 7 | ||||||||||||||||||||
| Q | T Lamasine | 6 | 6 | Q | T Lamasine | 2 | 66 | ||||||||||||||||||||
| PR | T Kokkinakis | 6 | 6 | 5 | H Gaston | 6 | 78 | ||||||||||||||||||||
 J Clarke | 2 | 4 | PR | T Kokkinakis | 2 | 3 | |||||||||||||||||||||
 E Escobedo | 3 | 4 | 5 | H Gaston | 6 | 6 | |||||||||||||||||||||
| 5 | H Gaston | 6 | 6 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 8 | S Diez | 6 | 2 | 3 | |||||||||||||||||||||||
| WC | A Pellegrino | 1 | 6 | 6 | WC | A Pellegrino | 79 | 6 | |||||||||||||||||||
| Q | F Cobolli | 7 | 5 | Q | F Cobolli | 67 | 1 | ||||||||||||||||||||
| A Vukic | 5 | 0r | WC | A Pellegrino | 2 | 6 | 6 | ||||||||||||||||||||
| WC | G Zeppieri | 6 | 6 | 4 | S Ofner | 6 | 2 | 3 | |||||||||||||||||||
| WC | S Napolitano | 3 | 4 | WC | G Zeppieri | 3 | 5 | ||||||||||||||||||||
| Q |  A Molčan | 79 | 0 | 3 | 4 | S Ofner | 6 | 7 | |||||||||||||||||||
| 4 | S Ofner | 67 | 6 | 6 | WC | A Pellegrino | 3 | 6 | 6 | ||||||||||||||||||
| 7 | L Giustino | 77 | 7 | Q | V Kopřiva | 6 | 1 | 1 | |||||||||||||||||||
| F Horanský | 62 | 5 | 7 | L Giustino | 6 | 6 | |||||||||||||||||||||
 S Stakhovsky | 6 | 3 | 7 | S Stakhovsky | 4 | 4 | |||||||||||||||||||||
| SE | M Bourgue | 4 | 6 | 5 | 7 | L Giustino | 6 | 5 | 3 | ||||||||||||||||||
| B Tomic | 6 | 6 | Q | V Kopřiva | 1 | 7 | 6 | ||||||||||||||||||||
 R Bemelmans | 3 | 4 | B Tomic | 3 | 3 | ||||||||||||||||||||||
| Q | V Kopřiva | 77 | 6 | Q | V Kopřiva | 6 | 6 | ||||||||||||||||||||
| 2 | H Dellien | 64 | 3 | ||||||||||||||||||||||||
Pablo Andújar was the two-time defending champion but lost in the first round to fellow countryman Pablo Carreño Busta.
Tommy Robredo won the title, defeating Kevin Anderson in the final, 7–6(8–6), 4–6, 6–3.
David Ferrer was the defending champion, but withdrew before the beginning of the tournament because of an ankle injury.
Carlos Berlocq won the title, defeating Fernando Verdasco in the final, 7–5, 6–1.
Benoît Paire was the defending champion, but chose to compete in Hamburg instead.
Tomáš Berdych was the defending champion and successfully defended his title, defeating Richard Gasquet in the final, 7−6(7−5), 6−7(2−7), 6−3.
Hugo Gaston and Clément Tabur won the boys' doubles tennis title at the 2018 Australian Open, defeating Rudolf Molleker and Henri Squire in the final, 6–2, 6–2.
Frances Tiafoe was the defending champion but chose not to defend his title.
Axel Geller and Hsu Yu-hsiou were the defending champions, but both players were ineligible to participate in junior events.
Tommy Paul won the title after defeating Tennys Sandgren 6–3, 6–4 in the final.
Alexander Zverev defeated top seed Stefanos Tsitsipas in the final, 6–4, 7–6(7–3) to win the men's singles tennis title at the 2021 Mexican Open.
Carlos Taberner was the defending champion but chose not to defend his title.
Tommy Robredo was the defending champion but chose not to defend his title.
Jaume Munar was the defending champion but chose not to defend his title.
Ugo Humbert was the defending champion but chose not to defend his title.
Félix Auger-Aliassime defeated Stefanos Tsitsipas in the final, 6–4, 6–2. It was his maiden ATP Tour singles title, following eight runner-up finishes in prior finals.
Defending champion Stefanos Tsitsipas defeated Alejandro Davidovich Fokina in the final, 6–3, 7–6(7–3) to win the singles tennis title at the 2022 Monte-Carlo Masters. He became the sixth player to win consecutive titles at the Monte-Carlo Masters in the Open Era. The win also earned him his second Masters 1000 title and his eighth career singles title overall.
Bernabé Zapata Miralles was the defending champion but chose not to defend his title.
Henri Laaksonen was the defending champion but lost in the first round to Evan Furness.
Jiří Veselý was the defending champion but chose not to defend his title.
Taro Daniel was the defending champion but chose not to defend his title.
Hugo Grenier was the defending champion but lost in the first round to Otto Virtanen.