| Doubles | |
|---|---|
| 2021 Heilbronner Neckarcup | |
| Champions |  Nathaniel Lammons Jackson Withrow |
| Runners-up |  André Göransson  Sem Verbeek |
| Score | 6–7(4–7), 6–4, [10–8] |
Kevin Krawietz and Andreas Mies were the defending champions [1] but chose not to defend their title.
Nathaniel Lammons and Jackson Withrow won the title after defeating André Göransson and Sem Verbeek 6–7(4–7), 6–4, [10–8] in the final.
Aisam-ul-Haq Qureshi / 
Andrei Vasilevski (semifinals) Sander Arends / 
Divij Sharan (semifinals) Nathaniel Lammons / Jackson Withrow (champions)
Rafael Matos / Felipe Meligeni Alves (quarterfinals)| First round | Quarterfinals | Semifinals | Final | ||||||||||||||||||||||||
| 1 | A-u-H Qureshi A Vasilevski | 77 | 6 | ||||||||||||||||||||||||
 L Glasspool  M Reid | 3 | 6 | [10] | L Glasspool M Reid | 61 | 4 | |||||||||||||||||||||
 LD Martínez  D Vega Hernández | 6 | 4 | [8] | 1 | A-u-H Qureshi A Vasilevski | 4 | 4 | ||||||||||||||||||||
| 4 | R Matos F Meligeni Alves | 6 | 6 | A Göransson S Verbeek | 6 | 6 | |||||||||||||||||||||
 I Sabanov M Sabanov | 3 | 0 | 4 | R Matos F Meligeni Alves | 4 | 65 | |||||||||||||||||||||
 D Masur  D Molchanov | 62 | 63 | A Göransson S Verbeek | 6 | 77 | ||||||||||||||||||||||
| A Göransson S Verbeek | 77 | 77 | A Göransson S Verbeek | 77 | 4 | [8] | |||||||||||||||||||||
| WC |  T Altuna A Çelikbilek | 4 | 4 | 3 | N Lammons J Withrow | 64 | 6 | [10] | |||||||||||||||||||
| D Kudla M McDonald | 6 | 6 | D Kudla M McDonald | 64 | 2 | ||||||||||||||||||||||
 DE Galán T Griekspoor | 3 | N Lammons J Withrow | 77 | 6 | |||||||||||||||||||||||
| 3 | N Lammons J Withrow | w/o | 3 | N Lammons J Withrow | 6 | 6 | |||||||||||||||||||||
M Polmans  A Sitak | 6 | 6 | 2 | S Arends D Sharan | 3 | 3 | |||||||||||||||||||||
| WC | A Begemann D Brown | 4 | 4 | M Polmans A Sitak | 2 | 6 | [8] | ||||||||||||||||||||
 T Daniel B Zapata Miralles | 2 | 5 | 2 | S Arends D Sharan | 6 | 3 | [10] | ||||||||||||||||||||
| 2 | S Arends D Sharan | 6 | 7 | ||||||||||||||||||||||||
Austin Krajicek and Jackson Withrow were the defending champions but only Withrow chose to defend his title, partnering Mitchell Krueger. Withrow lost in the first round to Lloyd Harris and Ruan Roelofse.
Robert Galloway and Nathaniel Lammons were the defending champions but only Lammons chose to defend his title, partnering Hunter Reese. Lammons lost in the first round to Sekou Bangoura and Sebastian Korda.
Martin Redlicki and Jackson Withrow were the defending champions but only Redlicki chose to defend his title, partnering Diego Hidalgo. Redlicki lost in the first round to Nam Ji-sung and Song Min-kyu.
Romain Arneodo and Andrei Vasilevski were the defending champions but chose not to defend their title.
Ariel Behar and Gonzalo Escobar were the defending champions but chose not to defend their title.
Pavel Kotov and Roman Safiullin were the defending champions but chose not to defend their title.
This was the second of seven editions of the tournament in the 2021 tennis season. Luis David Martínez and David Vega Hernández were the defending champions but lost in the quarterfinals to Nathaniel Lammons and Jackson Withrow.
This was the second edition of the tournament in the 2021 tennis season. Denys Molchanov and Aleksandr Nedovyesov were the defending champions but only Nedovyesov chose to defend his title, partnering Viktor Troicki. Nedovyesov lost in the semifinals to Nathan Pasha and Max Schnur.
Sadio Doumbia and Fabien Reboul were the defending champions and successfully defended their title, defeating Guido Andreozzi and Guillermo Durán 7–5, 6–3 in the final.
Santiago González and Aisam-ul-Haq Qureshi were the defending champions but chose not to defend their title.
Chris Guccione and Rajeev Ram were the defending champions but chose not to defend their title.
Ruben Gonzales and Ruan Roelofse were the defending champions but chose to defend their title with different partners. Gonzales partnered Hunter Johnson but lost in the first round to Hans Hach Verdugo and Miguel Ángel Reyes-Varela. Roelofse partnered Christopher Rungkat but lost in the quarterfinals to William Blumberg and Max Schnur.
Christopher Eubanks and Kevin King were the defending champions but chose not to defend their title.
Simone Bolelli and Máximo González were the defending champions but Bolelli chose not to participate. González was scheduled to partner Nicolás Jarry, but Jarry withdrew with a right elbow injury before their first round match.
Martín Cuevas and Paolo Lorenzi were the defending champions but chose not to defend their title.
Nathaniel Lammons and Jackson Withrow were the defending champions but only Withrow chose to defend his title, partnering Denys Molchanov. Withrow lost in the quarterfinals to Andrej Martin and Tristan-Samuel Weissborn.
Vít Kopřiva and Jiří Lehečka were the defending champions but chose not to defend their title.
Robert Lindstedt and Jonny O'Mara were the defending champions but chose not to defend their title.
Nathaniel Lammons and Jackson Withrow defeated Jason Kubler and Luke Saville in the final, 7–6(7–5), 6–2 to win the doubles tennis title at the 2022 San Diego Open.
Ivan Dodig and Austin Krajicek defeated Nicolas Mahut and Édouard Roger-Vasselin in the final, 6–4, 7–6(7–5) to win the doubles tennis title at the 2022 Swiss Indoors.