| Doubles | |
|---|---|
| 2021 IBG Prague Open | |
| Champions |  Victor Vlad Cornea  Petros Tsitsipas |
| Runners-up |  Martin Krumich Andrew Paulson |
| Final score | 6–3, 3–6, [10–8] |
Sander Arends and David Pel were the defending champions [1] but chose not to defend their title.
Victor Vlad Cornea and Petros Tsitsipas won the title after defeating Martin Krumich and Andrew Paulson 6–3, 3–6, [10–8] in the final.
Ruben Gonzales / 
Ruan Roelofse (first round)
Hsu Yu-hsiou / 
Benjamin Lock (quarterfinals)
Fabian Fallert / 
Hunter Johnson (quarterfinals) Victor Vlad Cornea / Petros Tsitsipas (champions)| First round | Quarterfinals | Semifinals | Final | ||||||||||||||||||||||||
| 1 | R Gonzales R Roelofse | 5 | 1 | ||||||||||||||||||||||||
 F Agamenone  H Casanova | 7 | 6 | F Agamenone H Casanova | 2 | 6 | [10] | |||||||||||||||||||||
| WC | J Forejtek Marek Gengel | 7 | 6 | WC | J Forejtek M Gengel | 6 | 3 | [6] | |||||||||||||||||||
 N Hardt  K Uchida | 5 | 3 | F Agamenone H Casanova | 6 | 62 | [4] | |||||||||||||||||||||
| 3 | F Fallert H Johnson | 6 | 2 | [10] | WC | M Krumich A Paulson | 2 | 77 | [10] | ||||||||||||||||||
 I Sijsling G Smits | 1 | 6 | [4] | 3 | F Fallert H Johnson | 4 | 6 | [4] | |||||||||||||||||||
 T Gabashvili A Vatutin | 1 | 62 | WC | M Krumich A Paulson | 6 | 2 | [10] | ||||||||||||||||||||
| WC | Martin Krumich A Paulson | 6 | 77 | WC | M Krumich A Paulson | 3 | 6 | [8] | |||||||||||||||||||
 O Roca Batalla N Sánchez Izquierdo | 4 | 66 | 4 | VV Cornea P Tsitsipas | 6 | 3 | [10] | ||||||||||||||||||||
 M Geerts  R Peniston | 6 | 78 | M Geerts R Peniston | 3 | 6 | [12] | |||||||||||||||||||||
| WC | Jiří Jeníček T Kodat | 4 | 5 | 4 | VV Cornea P Tsitsipas | 6 | 3 | [14] | |||||||||||||||||||
| 4 | VV Cornea P Tsitsipas | 6 | 7 | 4 | VV Cornea P Tsitsipas | w/o | |||||||||||||||||||||
| E Karlovskiy E Tiurnev | 2 | 2 |  G Blancaneaux A Cazaux | ||||||||||||||||||||||||
| G Blancaneaux A Cazaux | 6 | 6 | G Blancaneaux A Cazaux | 77 | 6 | ||||||||||||||||||||||
 M Cuevas GA Olivieri | 3 | 4 | 2 | Y-h Hsu B Lock | 65 | 2 | |||||||||||||||||||||
| 2 | Y-h Hsu B Lock | 6 | 6 | ||||||||||||||||||||||||
Potito Starace and Adrian Ungur were the defending champions, but Starace did not defend his title while Ungur partnering Victor Vlad Cornea lost in the first round. Victor Crivoi and Petru-Alexandru Luncanu won the title beating Ilija Bozoljac and Dušan Lajović in the final 6–4, 6–3.
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Victor Vlad Cornea and Fabian Fallert were the defending champions but lost in the final to Marco Bortolotti and Vitaliy Sachko.
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Nikola Ćaćić and Yang Tsung-hua were the defending champions but chose not to defend their title.
Gonçalo Oliveira and Andrei Vasilevski were the defending champions but chose not to defend their title.
Igor Sijsling and Tim van Rijthoven were the defending champions but chose not to defend their title.
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