| Singles | |
|---|---|
| 2021 IBG Prague Open | |
| Champion |  Franco Agamenone |
| Runner-up |  Ryan Peniston |
| Score | 6–3, 6–1 |
Aslan Karatsev was the defending champion [1] but chose not to defend his title.
Franco Agamenone won the title after defeating Ryan Peniston 6–3, 6–1 in the final.
Evgeny Karlovskiy (quarterfinals)
Alexander Ritschard (second round) Evgenii Tiurnev (first round)
Geoffrey Blancaneaux (second round)
Jonáš Forejtek (first round)
Michael Geerts (quarterfinals)
Filip Jianu (first round)
Miljan Zekić (first round, retired)| Semifinals | Final | ||||||||||||
 Genaro Alberto Olivieri | 1 | 5 | |||||||||||
| Ryan Peniston | 6 | 7 | |||||||||||
| Ryan Peniston | 3 | 1 | |||||||||||
| Franco Agamenone | 6 | 6 | |||||||||||
| Franco Agamenone | 6 | 6 | |||||||||||
 Igor Sijsling | 3 | 0 | |||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | E Karlovskiy | 6 | 6 | ||||||||||||||||||||||||
| H Casanova | 2 | 3 | 1 | E Karlovskiy | 5 | 6 | 6 | ||||||||||||||||||||
 R Molleker | 7 | 4 | 6 | R Molleker | 7 | 4 | 2 | ||||||||||||||||||||
| WC | A Paulson | 5 | 6 | 1 | 1 | E Karlovskiy | 78 | 4 | 4 | ||||||||||||||||||
 Y-h Hsu | 6 | 6 | GA Olivieri | 66 | 6 | 6 | |||||||||||||||||||||
| A Vatutin | 3 | 0 | Y-h Hsu | 3 | 4 | ||||||||||||||||||||||
| GA Olivieri | 6 | 6 | GA Olivieri | 6 | 6 | ||||||||||||||||||||||
| 5 | J Forejtek | 2 | 4 | GA Olivieri | 1 | 5 | |||||||||||||||||||||
| 3 | E Tiurnev | 66 | 2 | R Peniston | 6 | 7 | |||||||||||||||||||||
 M Pecotić | 78 | 6 | M Pecotić | 3 | 67 | ||||||||||||||||||||||
| Q | F Díaz Acosta | 6 | 6 | Q | F Díaz Acosta | 6 | 79 | ||||||||||||||||||||
| PR | M Donati | 1 | 3 | Q | F Díaz Acosta | 3 | 1 | ||||||||||||||||||||
| Q |  Z Piros | 4 | 3 | R Peniston | 6 | 6 | |||||||||||||||||||||
| Q |  U Ignatik | 6 | 6 | Q | U Ignatik | 2 | 6 | 3 | |||||||||||||||||||
| R Peniston | 6 | 4 | R Peniston | 6 | 2 | 6 | |||||||||||||||||||||
| 8 | M Zekić | 0 | 1r | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 6 | M Geerts | 6 | 6 | ||||||||||||||||||||||||
| WC | Martin Krumich | 2 | 4 | 6 | M Geerts | 6 | 6 | ||||||||||||||||||||
| J Härteis | 4 | 2 | Q | A Rybakov | 2 | 2 | |||||||||||||||||||||
| Q | A Rybakov | 6 | 6 | 6 | M Geerts | 7 | 5 | 3 | |||||||||||||||||||
 N Sánchez Izquierdo | 3 | 3 | F Agamenone | 5 | 7 | 6 | |||||||||||||||||||||
| F Agamenone | 6 | 6 | F Agamenone | 7 | 6 | ||||||||||||||||||||||
| A Cazaux | 4 | 66 | 4 | G Blancaneaux | 5 | 4 | |||||||||||||||||||||
| 4 | G Blancaneaux | 6 | 78 | F Agamenone | 6 | 6 | |||||||||||||||||||||
| 7 | FC Jianu | 64 | 2 | I Sijsling | 3 | 0 | |||||||||||||||||||||
 M Pucinelli de Almeida | 77 | 6 | M Pucinelli de Almeida | 2 | 6 | 2r | |||||||||||||||||||||
| WC | Daniel Siniakov | 4 | 3 | I Sijsling | 6 | 2 | 3 | ||||||||||||||||||||
| I Sijsling | 6 | 6 | I Sijsling | 7 | 6 | ||||||||||||||||||||||
 K Uchida | 6 | 3 | 6 | K Uchida | 5 | 3 | |||||||||||||||||||||
| N Chappell | 4 | 6 | 1 | K Uchida | 77 | 7 | |||||||||||||||||||||
| R Ortega Olmedo | 1 | 1 | 2 | A Ritschard | 64 | 5 | |||||||||||||||||||||
| 2 | A Ritschard | 6 | 6 | ||||||||||||||||||||||||
Richard Gasquet was the defending champion, but withdrew before the tournament began.
Marin Čilić won the title, defeating Roberto Bautista Agut in the final, 6–4, 6–4.
Marsel İlhan was the defending champion, but he lost in quarterfinals to Konstantin Kravchuk.
Tristan Lamasine was the defending champion but chose not to defend his title.
Marin Čilić was the two-time defending champion, but chose not to participate this year.
Kamil Majchrzak was the defending champion but chose not to defend his title.
Daniil Medvedev was the defending champion, but chose not to defend his title.
Matteo Berrettini defeated Aslan Karatsev in the final, 6–1, 3–6, 7–6(7–0) to win the men's singles tennis title at the 2021 Serbia Open.
Aslan Karatsev was the defending champion but chose not to defend his title.
John Millman was the defending champion, but lost in the quarterfinals to James Duckworth.
Andrey Rublev was the defending champion, but lost in the quarterfinals to Botic van de Zandschulp.
Aslan Karatsev defeated Andy Murray in the final, 6–3, 6–3 to win the men's singles title at the 2022 Sydney Tennis Classic. This was Murray's first ATP final since he won the 2019 European Open.
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Félix Auger-Aliassime defeated Stefanos Tsitsipas in the final, 6–4, 6–2. It was his maiden ATP Tour singles title, following eight runner-up finishes in prior finals.
Aslan Karatsev and Andrey Rublev were the defending champions but chose not to participate.
Andrey Rublev defeated Félix Auger-Aliassime in the final, 7–5, 7–6(7–4) to win the singles title at the 2022 Open 13 Provence.
Andrey Rublev defeated Jiří Veselý in the final, 6–3, 6–4 to win the men's singles title at the 2022 Dubai Tennis Championships. It was Rublev's tenth career singles title. Veselý entered the tournament ranked as the world No. 123, and was the lowest-ranked finalist in the tournament's history.
Andrey Rublev defeated Novak Djokovic in the final, 6–2, 6–7(4–7), 6–0 to win the singles tennis title at the 2022 Serbia Open.
Matteo Berrettini defeated Andy Murray in the final, 6–4, 5–7, 6–3 to win the singles tennis title at the 2022 Stuttgart Open.
Rafael Matos and David Vega Hernández defeated Ariel Behar and Gonzalo Escobar in the final, 7–6(7–5), 6–7(6–8), [10–1] to win the doubles tennis title at the 2022 Mallorca Championships. The pair earned their second ATP Tour doubles title of the season and first grass victory together.
Lorenzo Sonego defeated Alexander Bublik in the final, 7–6(7–3), 6–2 to win the singles tennis title at the 2022 Moselle Open.