| Singles | |
|---|---|
| 2021 President's Cup II | |
| Champion |  Andrey Kuznetsov |
| Runner-up |  Jason Kubler |
| Score | 6–3, 2–1 ret. |
Max Purcell was the defending champion [1] but chose not to defend his title.
Andrey Kuznetsov won the title after Jason Kubler retired trailing 3–6, 1–2 in the final.
Roman Safiullin (withdrew)
Sergiy Stakhovsky (second round)
Jay Clarke (first round)
Hugo Grenier (quarterfinals)
Peter Polansky (quarterfinals)
Jesper de Jong (second round)
Tseng Chun-hsin (second round) Wu Tung-lin (first round)| Semifinals | Final | ||||||||||||
| Pavel Kotov | 2 | 77 | 4 | ||||||||||
| Andrey Kuznetsov | 6 | 64 | 6 | ||||||||||
| Andrey Kuznetsov | 6 | 2 | |||||||||||
| Jason Kubler | 3 | 1r | |||||||||||
| Jason Kubler | 6 | 6 | |||||||||||
| Q | Oleksii Krutykh | 1 | 3 | ||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| LL |  E Kırkın | 2 | 3 | ||||||||||||||||||||||||
| R Peniston | 6 | 6 | R Peniston | 6 | 6 | ||||||||||||||||||||||
 A Bega | 3 | 6 | 3 | Y-h Hsu | 3 | 4 | |||||||||||||||||||||
| Y-h Hsu | 6 | 1 | 6 | R Peniston | 4 | 2 | |||||||||||||||||||||
| P Kotov | 3 | 6 | 6 | P Kotov | 6 | 6 | |||||||||||||||||||||
| Q |  E Leshem | 6 | 1 | 4 | P Kotov | 6 | 77 | ||||||||||||||||||||
 D Yevseyev | 6 | 0 | 3 | 6 | J de Jong | 3 | 63 | ||||||||||||||||||||
| 6 | J de Jong | 4 | 6 | 6 | P Kotov | 2 | 77 | 4 | |||||||||||||||||||
| 3 | J Clarke | 66 | 4 | A Kuznetsov | 6 | 64 | 6 | ||||||||||||||||||||
| A Kuznetsov | 78 | 6 | A Kuznetsov | 6 | 7 | ||||||||||||||||||||||
| WC | B Zhukayev | 6 | 6 | WC | B Zhukayev | 2 | 5 | ||||||||||||||||||||
 L Catarina | 2 | 4 | A Kuznetsov | 6 | 3 | 6 | |||||||||||||||||||||
| A Zakharov | 0 | 2 | 5 | P Polansky | 2 | 6 | 2 | ||||||||||||||||||||
 M Jaziri | 6 | 6 | M Jaziri | 6 | 5 | 64 | |||||||||||||||||||||
| Q | A Dubrivnyy | 5 | 65 | 5 | P Polansky | 3 | 7 | 77 | |||||||||||||||||||
| 5 | P Polansky | 7 | 77 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 7 | C-h Tseng | 6 | 6 | ||||||||||||||||||||||||
| C Denolly | 4 | 4 | 7 | C-h Tseng | 6 | 3 | 5 | ||||||||||||||||||||
| J Kubler | 6 | 7 | J Kubler | 0 | 6 | 7 | |||||||||||||||||||||
 K Sultanov | 3 | 5 | J Kubler | 77 | 6 | ||||||||||||||||||||||
| WC | Dostanbek Tashbulatov | 3 | 2 | 4 | H Grenier | 64 | 1 | ||||||||||||||||||||
| I Nedelko | 6 | 6 | I Nedelko | 5r | |||||||||||||||||||||||
 Y-s Chung | 77 | 3 | 1 | 4 | H Grenier | 6 | |||||||||||||||||||||
| 4 | H Grenier | 65 | 6 | 6 | J Kubler | 6 | 6 | ||||||||||||||||||||
| 8 | T-l Wu | 2 | 2 | Q | O Krutykh | 1 | 3 | ||||||||||||||||||||
| Q | O Krutykh | 6 | 6 | Q | O Krutykh | 4 | 7 | 6 | |||||||||||||||||||
 M Bašić | 6 | 6 | M Bašić | 6 | 5 | 2 | |||||||||||||||||||||
| A Santillan | 2 | 2 | Q | O Krutykh | 3 | 6 | 7 | ||||||||||||||||||||
| WC | G Lomakin | 3 | 63 |  N Chappell | 6 | 3 | 5 | ||||||||||||||||||||
| N Chappell | 6 | 77 | N Chappell | 77 | 6 | ||||||||||||||||||||||
| Q |  B Lock | 3 | 6 | 5 | 2 | S Stakhovsky | 64 | 4 | |||||||||||||||||||
| 2 | S Stakhovsky | 6 | 3 | 7 | |||||||||||||||||||||||
Gene Mayer was the defending champion, but did not participate this year.
Brian Gottfried was the defending champion and won in the final 6–2, 6–3, 7–5 against Mel Purcell.
Elizabeth Sayers and John Fitzgerald were the defending champions but lost in the final 2–6, 7–5, 6–4 against Manuela Maleeva and Tom Gullikson.
Gilles Müller was the defending champion, but lost in the second round to Matthew Ebden.
Michael Mmoh was the defending champion but chose not to defend his title.
Maverick Banes was the defending champion but lost in the first round to Shintaro Imai.
Alexei Popyrin was the defending champion but chose not to defend his title.
Blaž Kavčič was the defending champion but chose not to defend his title.
Jordan Thompson was the defending champion but chose not to defend his title.
Rogério Dutra Silva was the defending champion but chose not to defend his title.
Ričardas Berankis was the defending champion but chose not to defend his title.
Alexander and Mischa Zverev were the defending champions, but lost to Adrian Mannarino and Fabrice Martin in the quarterfinals.
Evgeny Donskoy was the defending champion but chose not to defend his title.
J. J. Wolf was the defending champion but lost in the semifinals to Stefan Kozlov.
Reilly Opelka defeated John Isner in the final, 6–3, 7–6(9–7), to win the singles tennis title at the 2022 U.S. Men's Clay Court Championships. It marked Opelka's fourth career Association of Tennis Professionals (ATP) singles title and his first on clay. With Opelka's height at 6 ft 11 in (211 cm) and Isner's at 6 ft 10 in (208 cm), the combined heights of both players made the final the tallest one ever contended during the Open Era. At the age of 36, Isner was also playing to become the oldest champion at the tournament in the Open Era.
Matthew Ebden and Max Purcell defeated Ivan and Matej Sabanov in the final, 6–3, 6–3 to win the doubles tennis title at the 2022 U.S. Men's Clay Court Championships. They did not drop a set en route to their first ATP Tour doubles title as a team.
Daniil Medvedev defeated the defending champion Cameron Norrie in the final, 7–5, 6–0 to win the singles tennis title. It was his 14th career ATP Tour title, his first of the season, and his first since the 2021 US Open eleven months earlier.
Stuart Parker was the defending champion but lost in the qualifying competition to Giovanni Fonio.
Zsombor Piros was the defending champion but chose not to defend his title.
Kamil Majchrzak was the defending champion but chose not to defend his title.