| Singles | |
|---|---|
| 2021 Puerto Vallarta Open | |
| Champion |  Daniel Altmaier |
| Runner-up |  Alejandro Tabilo |
| Score | 6–3, 3–6, 6–3 |
Sebastian Ofner was the defending champion [1] but chose not to defend his title.
Daniel Altmaier won the title after defeating Alejandro Tabilo 6–3, 3–6, 6–3 in the final.
Pablo Cuevas (quarterfinals, retired) Daniel Altmaier (champion) Alejandro Tabilo (final)
Ernesto Escobedo (first round) Michael Mmoh (semifinals) Christian Harrison (second round)
Wu Tung-lin (second round)
Tatsuma Ito (quarterfinals)| Semifinals | Final | ||||||||||||
| Yosuke Watanuki | 3 | 2 | |||||||||||
| 3 | Alejandro Tabilo | 6 | 6 | ||||||||||
| 3 | Alejandro Tabilo | 3 | 6 | 3 | |||||||||
| 2 | Daniel Altmaier | 6 | 3 | 6 | |||||||||
| 5 | Michael Mmoh | 4 | 2 | ||||||||||
| 2 | Daniel Altmaier | 6 | 6 | ||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | P Cuevas | 7 | 6 | ||||||||||||||||||||||||
| A Kovacevic | 5 | 4 | 1 | P Cuevas | 77 | 0 | |||||||||||||||||||||
| Alt |  MF Descotte | 62 | 7 | 6 | Alt | MF Descotte | 63 | 0r | |||||||||||||||||||
| WC |  G López Villaseñor | 77 | 5 | 0 | 1 | P Cuevas | 6 | 4 | 0r | ||||||||||||||||||
| Yo Watanuki | 6 | 6 | Yo Watanuki | 4 | 6 | 2 | |||||||||||||||||||||
| PR |  R Statham | 3 | 2 | Yo Watanuki | 65 | 7 | 6 | ||||||||||||||||||||
| Q |  L Draxl | 3 | 1 | 7 | T-l Wu | 77 | 5 | 3 | |||||||||||||||||||
| 7 | T-l Wu | 6 | 6 | Yo Watanuki | 3 | 2 | |||||||||||||||||||||
| 3 | A Tabilo | 6 | 6 | 3 | A Tabilo | 6 | 6 | ||||||||||||||||||||
 A Menéndez Maceiras | 3 | 2 | 3 | A Tabilo | 6 | 6 | |||||||||||||||||||||
| WC | Milledge Cossu | 1 | 3 | D Young | 2 | 1 | |||||||||||||||||||||
| D Young | 6 | 6 | 3 | A Tabilo | 6 | 6 | |||||||||||||||||||||
| A Rybakov | 7 | 4r | 8 | T Ito | 2 | 2 | |||||||||||||||||||||
| Q | A Hernández | 5 | 4 | Q | A Hernández | 2 | 3 | ||||||||||||||||||||
 G Brouwer | 2 | 63 | 8 | T Ito | 6 | 6 | |||||||||||||||||||||
| 8 | T Ito | 6 | 77 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 5 | M Mmoh | 6 | 6 | ||||||||||||||||||||||||
| N Chappell | 2 | 3 | 5 | M Mmoh | 7 | 4 | 6 | ||||||||||||||||||||
| WC |  J Shang | 6 | 6 | WC | J Shang | 5 | 6 | 4 | |||||||||||||||||||
| Alt | M Cuevas | 4 | 4 | 5 | M Mmoh | 79 | 6 | ||||||||||||||||||||
| K Uchida | 6 | 6 | K Uchida | 67 | 3 | ||||||||||||||||||||||
| PR | A Sarkissian | 3 | 4 | K Uchida | 6 | 6 | |||||||||||||||||||||
| A Galarneau | 7 | 64 | 7 | A Galarneau | 4 | 2 | |||||||||||||||||||||
| 4 | E Escobedo | 5 | 77 | 5 | 5 | M Mmoh | 4 | 2 | |||||||||||||||||||
| 6 | C Harrison | 6 | 6 | 2 | D Altmaier | 6 | 6 | ||||||||||||||||||||
| R Ortega Olmedo | 4 | 0 | 6 | C Harrison | 1 | 69 | |||||||||||||||||||||
| Q | Christian Langmo | 7 | 4 | 5 | Z Svajda | 6 | 711 | ||||||||||||||||||||
| Z Svajda | 5 | 6 | 7 | Z Svajda | 6 | 68 | 3 | ||||||||||||||||||||
| Q | G Nanda | 6 | 6 | 2 | D Altmaier | 4 | 710 | 6 | |||||||||||||||||||
| JC Aragone | 2 | 0 | Q | G Nanda | 3 | 3 | |||||||||||||||||||||
| Mi Redlicki | 65 | 1 | 2 | D Altmaier | 6 | 6 | |||||||||||||||||||||
| 2 | D Altmaier | 77 | 6 | ||||||||||||||||||||||||
Stan Wawrinka was the defending champion and successfully defended his title, defeating Mischa Zverev in the final, 4–6, 6–3, 6–3.
Salvatore Caruso was the defending champion but lost in the second round to Jan Choinski.
Thanasi Kokkinakis was the defending champion but chose not to defend his title.
Maxime Cressy was the defending champion but lost in the third round to Ulises Blanch.
Matías Franco Descotte was the defending champion but lost in the second round to Jurij Rodionov.
Botic van de Zandschulp was the defending champion but withdrew before his semifinal match against Taro Daniel.
Cristian Garín defeated Facundo Bagnis in the final, 6–4, 6–7(3–7), 7–5 to capture the men's singles tennis title at the 2021 Chile Open.
Hugo Dellien was the defending champion but chose not to defend his title.
Hubert Hurkacz defeated Jannik Sinner in the final, 7–6(7–4), 6–4 to win the men's singles tennis title at the 2021 Miami Open. Hurkacz claimed his first Masters 1000 singles championship and became the first Pole to win a Masters 1000 singles title.
Matteo Berrettini defeated Cameron Norrie in the final, 6–4, 6–7(5–7), 6–3, to win the singles tennis title at the 2021 Queen's Club Championships. Berrettini's win earned him his fourth career ATP Tour singles title, his first ATP 500 victory, and also made him the first player to win the tournament on their main draw debut since Boris Becker in 1985. Norrie was contesting for his first title in his fourth career final.
Jannik Sinner was the defending champion but chose not to defend his title.
Francisco Cerúndolo was the defending champion but lost in the second round to Gonçalo Oliveira.
Albert Ramos Viñolas defeated Alejandro Tabilo in the final, 4–6, 6–3, 6–4 to win the singles title at the 2022 Córdoba Open.
Sebastián Báez was the defending champion but chose not to defend his title.
Tommy Paul was the defending champion but chose not to defend his title.
Dalibor Svrčina was the defending champion but lost in the final to Sebastian Ofner.
Stefanos Tsitsipas defeated Roberto Bautista Agut in the final, 6–4, 3–6, 7–6(7–2) to win the men's singles tennis title at the 2022 Mallorca Championships.
Alejandro Tabilo was the defending champion but chose not to defend his title.
Daniel Elahi Galán was the defending champion but chose not to defend his title.
Matteo Arnaldi was the defending champion but chose not to defend his title.