| Doubles | |
|---|---|
| 2021 Tennis Napoli Cup | |
| Champions |  Dustin Brown  Andrea Vavassori |
| Runners-up |  Mirza Bašić  Nino Serdarušić |
| Score | 7–5, 7–6(7–5) |
Gero Kretschmer and Alexander Satschko were the defending champions [1] but chose not to defend their title.
Dustin Brown and Andrea Vavassori won the title after defeating Mirza Bašić and Nino Serdarušić 7–5, 7–6(7–5) in the final.
Dustin Brown / Andrea Vavassori (champions)
Sadio Doumbia / Fabien Reboul (quarterfinals)
James Cerretani / Fabian Fallert (quarterfinals) Yannick Hanfmann / 
Luca Margaroli (quarterfinals)| First round | Quarterfinals | Semifinals | Final | ||||||||||||||||||||||||
| 1 | D Brown A Vavassori | 6 | 6 | ||||||||||||||||||||||||
 VV Cornea  P Tsitsipas | 2 | 2 | 1 | D Brown A Vavassori | 6 | 77 | |||||||||||||||||||||
| PR | F Baldi J Ocleppo | 4 | 65 | ||||||||||||||||||||||||
| 1 | D Brown A Vavassori | 6 | 6 | ||||||||||||||||||||||||
 T Griekspoor B Stevens | 3 | 4 | |||||||||||||||||||||||||
| 4 | Y Hanfmann L Margaroli | 2 | 5 | ||||||||||||||||||||||||
| T Griekspoor B Stevens | 6 | 6 | T Griekspoor B Stevens | 6 | 7 | ||||||||||||||||||||||
| Alt | D Ajduković F Ninčević | 3 | 0 | 1 | D Brown A Vavassori | 7 | 77 | ||||||||||||||||||||
| M Bašić N Serdarušić | 6 | 6 | M Bašić N Serdarušić | 5 | 65 | ||||||||||||||||||||||
| WC | M Arnaldi Lorenzo Peluso | 2 | 4 | M Bašić N Serdarušić | 6 | 6 | |||||||||||||||||||||
| J Berrettini R Brancaccio | 3 | 77 | [6] | 3 | J Cerretani F Fallert | 4 | 4 | ||||||||||||||||||||
| 3 | J Cerretani F Fallert | 6 | 65 | [10] | M Bašić N Serdarušić | 77 | 7 | ||||||||||||||||||||
 A Martin  T-S Weissborn | 6 | 6 | A Martin T-S Weissborn | 64 | 5 | ||||||||||||||||||||||
| GM Moroni A Pellegrino | 3 | 3 | A Martin T-S Weissborn | 7 | 2 | [10] | |||||||||||||||||||||
| WC | F Cobolli M Gigante | 3 | 3 | 2 | S Doumbia F Reboul | 5 | 6 | [7] | |||||||||||||||||||
| 2 | S Doumbia F Reboul | 6 | 6 | ||||||||||||||||||||||||
Sander Arends and Antonio Šančić were the defending champions but chose not to defend their title.
Scott Clayton and Jonny O'Mara were the defending champions but only Clayton chose to defend his title, partnering Adil Shamasdin. Clayton lost in the semifinals to Laurynas Grigelis and Zdeněk Kolář.
Jamie Murray and Bruno Soares were the defending champions, but lost in the first round to Robert Lindstedt and Frances Tiafoe.
Julian Ocleppo and Andrea Vavassori were the defending champions but chose to defend their title with different partners. Ocleppo partnered Andrea Pellegrino but lost in the first round to David Marrero and Roberto Maytín. Vavassori partnered Andrei Vasilevski but lost in the final to Tomislav Brkić and Ante Pavić.
Andrés Artuñedo and David Pérez Sanz were the defending champions but only Artuñedo chose to defend his title, partnering Sergio Martos Gornés. Artuñedo lost in the first round to Andreas Siljeström and Andrea Vavassori.
Andre Begemann and Dustin Brown were the defending champions but only Begemann chose to defend his title, partnering Florin Mergea.
Dustin Brown and Donald Young were the defending champions but chose not to defend their title.
John Peers and Michael Venus were the defending champions, but they chose not to participate.
Austin Krajicek and Franko Škugor were the defending champions, but Krajicek chose to compete at the Summer Olympics and Škugor chose not to defend his title.
This was the first edition of the tournament.
This was the first edition of the tournament.
Dustin Brown and Antoine Hoang were the defending champions but only Brown chose to defend his title, partnering Andrea Vavassori. Brown lost in the quarterfinals to Ruben Bemelmans and Daniel Masur.
Sadio Doumbia and Fabien Reboul were the defending champions but chose not to defend their title.
Ivan and Matej Sabanov were the defending champions but lost in the quarterfinals to Matteo Arnaldi and Francesco Passaro.
Orlando Luz and Rafael Matos were the defending champions but chose not to defend their title.
Dustin Brown and Andrea Vavassori were the defending champions but only Brown chose to defend his title, partnering Evan King. Brown lost in the first round to Lukáš Klein and Igor Zelenay.
Santiago González and Andrés Molteni were the defending champions but chose not to defend their title.
Ariel Behar and Gonzalo Escobar were the defending champions but chose not to defend their title.
Ivan Dodig and Austin Krajicek defeated Matthew Ebden and John Peers in the final, 6–3, 1–6, [10–8] to win the doubles tennis title at the 2022 Tennis Napoli Cup.
Antonio Šančić and Tristan-Samuel Weissborn were the defending champions but only Weissborn chose to defend his title, partnering Romain Arneodo. Weissborn lost in the quarterfinals to Marco Bortolotti and Sergio Martos Gornés.