| Doubles | |
|---|---|
| 2021 Wiesbaden Tennis Open | |
| Champions |  Anna Bondár  Lara Salden |
| Runners-up |  Arianne Hartono  Olivia Tjandramulia |
| Final score | 6–7(9–11), 6–2, [10–4] |
Anna Blinkova and Yanina Wickmayer were the defending champions [1] but chose not to participate.
Anna Bondár and Lara Salden won the title, defeating Arianne Hartono and Olivia Tjandramulia in the final, 6–7(9–11), 6–2, [10–4].
Lina Gjorcheska / 
Xenia Knoll (Quarterfinals) Réka Luca Jani / 
Valeriya Strakhova (First round)
Marina Melnikova / Conny Perrin (Quarterfinals) Anna Bondár / Lara Salden (Champions)| First Round | Quarterfinals | Semifinals | Final | ||||||||||||||||||||||||
| 1 | L Gjorcheska X Knoll | 1 | 4 | ||||||||||||||||||||||||
| E Kazionova E Makarova | 65 | 63 |  A Klasen A Zaja | 6 | 6 | ||||||||||||||||||||||
| A Klasen A Zaja | 77 | 77 | A Klasen A Zaja | 3 | 1 | ||||||||||||||||||||||
| 4 | A Bondár L Salden | 6 | 6 | 4 | A Bondár L Salden | 6 | 6 | ||||||||||||||||||||
| T Morderger Y Morderger | 4 | 2 | 4 | A Bondár L Salden | 6 | 6 | |||||||||||||||||||||
 D Marcinkēviča  C Scholl | 6 | 63 | [9] |  M Di Giuseppe G Gatto-Monticone | 2 | 2 | |||||||||||||||||||||
| M Di Giuseppe G Gatto-Monticone | 4 | 77 | [11] | 4 | A Bondár L Salden | 69 | 6 | [10] | |||||||||||||||||||
| A Hartono O Tjandramulia | 6 | 6 | A Hartono O Tjandramulia | 711 | 2 | [4] | |||||||||||||||||||||
| K Bartone G Poznikhirenko | 1 | 3 | A Hartono O Tjandramulia | 6 | 6 | ||||||||||||||||||||||
| H Lodewijks K van der Heijden | 3 | 0 | 3 | M Melnikova C Perrin | 4 | 3 | |||||||||||||||||||||
| 3 | M Melnikova C Perrin | 6 | 6 | A Hartono O Tjandramulia | 6 | 6 | |||||||||||||||||||||
 C Bucșa  T Mrdeža | 3 | 4 |  İ Öz  N Radišić | 3 | 3 | ||||||||||||||||||||||
| İ Öz N Radišić | 6 | 6 | İ Öz N Radišić | 6 | 6 | ||||||||||||||||||||||
| A Turati B Turati | 65 | 6 | [10] | A Turati B Turati | 0 | 2 | |||||||||||||||||||||
| 2 | RL Jani V Strakhova | 77 | 3 | [4] | |||||||||||||||||||||||
Belinda Bencic was the 2013 champion, but she did not defend her title after receiving a place in the women's singles main draw.
Belinda Bencic was the defending champion, but chose to compete in the women's singles.
Anabel Medina Garrigues and Klára Koukalová were the defending champions, but they chose not to participate.
Andreja Klepač and María Teresa Torró Flor won the title, defeating Jocelyn Rae and Anna Smith in the final, 6–1, 6–1.
Michaëlla Krajicek and Karolína Plíšková were the defending champions, but chose not to participate this year.
Chan Hao-ching and Anabel Medina Garrigues won the title, defeating Lara Arruabarrena and Raluca Olaru in the final, 6–4, 7–6(7–5).
Tami Grende and Ye Qiuyu were the defending champions, but chose not to participate.
Lara Arruabarrena and María Teresa Torró Flor were the defending champions, but chose not to compete together. Arruabarrena played alongside Paula Cristina Gonçalves, but lost in the quarterfinals to María Irigoyen and Paula Kania. Torró Flor was scheduled to team up with Shahar Pe'er, but withdrew before their first round match.
Anabel Medina Garrigues and Arantxa Parra Santonja won the title, defeating Kiki Bertens and Johanna Larsson in the final, 6–0, 6–4.
Sofya Zhuk was the defending champion, but chose not to participate this year.
Lara Arruabarrena and Xenia Knoll were the defending champions, but Arruabarrena chose not to participate this year. Knoll played alongside Anastasiya Komardina, but lost in the quarterfinals to Anna Kalinskaya and Evgeniya Rodina.
Cristina Dinu and Ganna Poznikhirenko were the defending champions, but lost to Andrea Gámiz and Paula Cristina Gonçalves in the quarterfinals.
Dayana Yastremska was the defending champion, but chose to participate in Nottingham instead.
Anastasija Sevastova was the defending champion, but lost in the second round to Patricia Maria Țig.
This was a new tournament in 2021.
This was the first edition of the tournament.
Natela Dzalamidze and Nina Stojanović were the defending champions, having won the previous edition in 2019, but Stojanović chose not to participate. Dzalamidze played alongside Paula Kania-Choduń but lost in the quarterfinals to Valentini Grammatikopoulou and Richèl Hogenkamp.
Misaki Doi and Natalia Vikhlyantseva were the defending champions but Doi chose not to participate. Vikhlyantseva played alongside Olga Govortsova but lost in the first round to Cornelia Lister and Erin Routliffe.
Flavia Pennetta won the title in 2004, but she retired from tennis in 2015.
Chantal Škamlová and Tereza Smitková were the defending champions but Škamlová chose not to participate. Smitková played alongside Tereza Mihalíková, but lost in the first round to Lara Salden and Daniela Vismane.
The 2021 Wiesbaden Tennis Open was a professional women's tennis tournament played on outdoor clay courts. It was the twelfth edition of the tournament which was part of the 2021 ITF Women's World Tennis Tour. It took place in Wiesbaden, Germany between 20 and 26 September 2021.
Barbora Krejčíková was the defending champion but chose not to participate.
Lara Salden is a Belgian tennis player.