Marcelo Demoliner and João Souza were the defending champions but they decided not to participate.
Unseeded pairs Guido Andreozzi and Máximo González defeated another unseeded pairing of Thiago Alves and Thiago Monteiro 6–4, 6–4.
Guido Andreozzi and Máximo González were the defending champions, but they chose not to compete together. Andreozzi chose to partner with Guillermo Durán, but lost in the quarterfinals to Rafael Matos and Marcelo Zormann. González chose not to compete.
Guillermo Durán and Máximo González were the defending champions, but González chose to participate at Shenzhen instead. Durán partnered with Guido Andreozzi and won the title by defeating Facundo Bagnis and Diego Schwartzman 6–3, 6–3 in the final.
Guillermo Durán and Máximo González were the defending champions, but González chose not to play this year. Guillermo Durán played alongside Andrés Molteni and lost in the first round to Guido Andreozzi and Guido Pella.
Andrej Martin and Igor Zelenay are the defending champions, but Martin did not return to defend his title. Zelenay plays alongside Mateusz Kowalczyk, they lost already in the first round to Guido Andreozzi and Nicolás Jarry.
Romain Arneodo and Fernando Romboli were the defending champions but only Romboli chose to defend his title, partnering Fabrício Neis. Romboli lost in the first round to Sergio Galdós and Federico Zeballos.
Facundo Bagnis and Ariel Behar were the defending champions but only Bagnis chose to defend his title, partnering Franco Agamenone. Bagnis lost in the first round to Sander Gillé and Joran Vliegen.
Guido Andreozzi and Guillermo Durán were the defending champions but chose not to defend their title.
Guido Andreozzi and Guillermo Durán were the defending champions but only Durán chose to defend his title, partnering Mariano Kestelboim. Durán lost in the first round to Facundo Mena and Camilo Ugo Carabelli.
Guido Andreozzi and Andrés Molteni were the defending champions but only Andreozzi chose to defend his title, partnering Thiago Seyboth Wild. Andreozzi withdrew from the tournament before his quarterfinal match.
The 2022 Challenger de Buenos Aires was a professional tennis tournament played on clay courts. It was the eleventh edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Buenos Aires, Argentina between 26 September and 2 October 2022.
Julio Peralta and Horacio Zeballos were the defending champions when the event was last held in 2015, but they chose not to defend their title.
Francesco Forti and Giulio Zeppieri were the defending champions but chose not to defend their title.
This was the first edition of the tournament.
Rafael Matos and Felipe Meligeni Alves were the defending champions but only Meligeni Alves chose to defend his title, partnering Matheus Pucinelli de Almeida. Meligeni Alves withdrew before his first round match due to injury.
Guillermo Durán and Nicolás Mejía were the defending champions but chose not to defend their title.
Ignacio Carou and Facundo Mena were the defending champions but chose not to defend their title.
Jesper de Jong and Bart Stevens were the defending champions but only de Jong chose to defend his title, partnering Max Houkes. De Jong and Houkes retired from their first round match against Boris Arias and Federico Zeballos.
Rafael Matos and Felipe Meligeni Alves were the defending champions but only Meligeni Alves chose to defend his title, partnering Matheus Pucinelli de Almeida. They withdrew before their first round match.
Facundo Mena was the defending champion but chose not to defend his title.
Guido Andreozzi 
