| Singles | |
|---|---|
| 2022 Cleveland Open | |
| Champion |  Dominic Stricker |
| Runner-up |  Yoshihito Nishioka |
| Score | 7–5, 6–1 |
Bjorn Fratangelo was the defending champion [1] but lost in the first round to Nicola Kuhn.
Dominic Stricker won the title after defeating Yoshihito Nishioka 7–5, 6–1 in the final.
Tennys Sandgren (second round)
Andreas Seppi (first round) Yoshihito Nishioka (final)
Liam Broady (second round)
Jurij Rodionov (second round) Ernesto Escobedo (quarterfinals)
Emilio Gómez (second round, retired) Jack Sock (second round, retired)| Semifinals | Final | ||||||||||||
| Thomas Fabbiano | 66 | 3 | |||||||||||
| 3 | Yoshihito Nishioka | 78 | 6 | ||||||||||
| 3 | Yoshihito Nishioka | 5 | 1 | ||||||||||
| Dominic Stricker | 7 | 6 | |||||||||||
| Michael Mmoh | 6 | 3 | 62 | ||||||||||
| Dominic Stricker | 3 | 6 | 77 | ||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | T Sandgren | 77 | 3 | 77 | |||||||||||||||||||||||
| C Harrison | 65 | 6 | 63 | 1 | T Sandgren | 6 | 4 | 1 | |||||||||||||||||||
| T Fabbiano | 7 | 6 | T Fabbiano | 3 | 6 | 6 | |||||||||||||||||||||
| M Krueger | 5 | 3 | T Fabbiano | 6 | 6 | ||||||||||||||||||||||
 C-M Stebe | 4 | 6 | 6 | C-M Stebe | 1 | 3 | |||||||||||||||||||||
 M Torpegaard | 6 | 4 | 2 | C-M Stebe | 7 | 3 | 6 | ||||||||||||||||||||
| Q |  R Hijikata | 64 | 3 | 5 | J Rodionov | 5 | 6 | 1 | |||||||||||||||||||
| 5 | J Rodionov | 77 | 6 | T Fabbiano | 66 | 3 | |||||||||||||||||||||
| 3 | Y Nishioka | 6 | 6 | 3 | Y Nishioka | 78 | 6 | ||||||||||||||||||||
 D Istomin | 1 | 1 | 3 | Y Nishioka | 6 | 1 | 6 | ||||||||||||||||||||
| Y Uchiyama | 6 | 6 | Y Uchiyama | 4 | 6 | 4 | |||||||||||||||||||||
| Q | S Fanselow | 4 | 3 | 3 | Y Nishioka | 3 | 6 | 6 | |||||||||||||||||||
| Q | R Quiroz | 4 | 79 | 4 | WC | W Blumberg | 6 | 4 | 2 | ||||||||||||||||||
| WC | W Blumberg | 6 | 67 | 6 | WC | W Blumberg | 6 | 3 | |||||||||||||||||||
 J Jung | 3 | 4 | 7 | E Gómez | 1 | 1r | |||||||||||||||||||||
| 7 | E Gómez | 6 | 6 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 8 | J Sock | 2 | 6 | 6 | |||||||||||||||||||||||
 B Schnur | 6 | 4 | 3 | 8 | J Sock | 1 | 1r | ||||||||||||||||||||
| M Mmoh | 6 | 6 | M Mmoh | 6 | 2 | ||||||||||||||||||||||
| WC | A Kovacevic | 4 | 2 | M Mmoh | 63 | 6 | 6 | ||||||||||||||||||||
| Q | A Galarneau | 77 | 77 | Q | A Galarneau | 77 | 3 | 0 | |||||||||||||||||||
| Q | U Blanch | 65 | 63 | Q | A Galarneau | 6 | 7 | ||||||||||||||||||||
| J. J. Wolf | 4 | 1 | 4 | L Broady | 1 | 5 | |||||||||||||||||||||
| 4 | L Broady | 6 | 6 | M Mmoh | 6 | 3 | 62 | ||||||||||||||||||||
| 6 | E Escobedo | 77 | 6 | D Stricker | 3 | 6 | 77 | ||||||||||||||||||||
| WC | K Smith | 63 | 4 | 6 | E Escobedo | 66 | 7 | 4 | |||||||||||||||||||
| N Kuhn | 710 | 6 | N Kuhn | 78 | 5 | 0r | |||||||||||||||||||||
| B Fratangelo | 68 | 4 | 6 | E Escobedo | 3 | 64 | |||||||||||||||||||||
 G Blancaneaux | 4 | 77 | 65 | D Stricker | 6 | 77 | |||||||||||||||||||||
| Q | Em Nava | 6 | 65 | 77 | Q | Em Nava | 6 | 3 | 4 | ||||||||||||||||||
| D Stricker | 6 | 6 | D Stricker | 3 | 6 | 6 | |||||||||||||||||||||
| 2 | A Seppi | 4 | 4 | ||||||||||||||||||||||||
Marin Čilić was the defending champion, but withdrew due to injury.
Pablo Cuevas was the defending champion but chose not to compete.
James Duckworth is the defending champion, but chose not to participate.
Marcos Baghdatis was the defending champion but chose not to compete.
Yoshihito Nishioka won the title, defeating Alexander Kudryavtsev in the final 6–3, 6–4.
Three-time defending champion Kei Nishikori successfully defended his title, defeating Taylor Fritz in the final, 6–4, 6–4 to win the singles title at the 2016 Memphis Open. Notably, this was only Fritz' third career event on the ATP Tour.
Ivo Karlović was the defending champion, but lost to John-Patrick Smith in the first round.
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This was the first edition of the men's singles tournament.
John Millman was the defending champion but chose not to defend his title.
Kevin Anderson was the defending champion, but lost in the second round to Jiří Veselý.
This was the first edition of the tournament.
Sam Querrey defeated Rafael Nadal in the final, 6–3, 7–6(7–3) to win the men's singles tennis title at the 2017 Mexican Open.
David Goffin was the defending champion, but lost in the second round to Andy Murray.
Andrey Rublev was the defending champion, but lost in the quarterfinals to Botic van de Zandschulp.
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Stefan Kozlov was the defending champion but lost in the second round to Dominic Stricker.
This was the first edition of the tournament.
Nick Kyrgios defeated Yoshihito Nishioka in the final, 6–4, 6–3 to win the men's singles tennis title at the 2022 Washington Open. It was his second Washington title, following 2019. Kyrgios saved five match points en route to the title, in the quarterfinals against Frances Tiafoe. He also did not drop serve during the tournament.
Daniil Medvedev defeated Denis Shapovalov in the final, 4–6, 6–3, 6–2 to win the singles tennis title at the 2022 Vienna Open.