| Singles | |
|---|---|
| 2022 Knoxville Challenger | |
| Champion |  Ben Shelton |
| Runner-up | Christopher Eubanks |
| Score | 6–3, 1–6, 7–6(7–4) |
Christopher Eubanks was the defending champion [1] but lost in the final to Ben Shelton.
Shelton won the title after defeating Eubanks 6–3, 1–6, 7–6(7–4) in the final.
Michael Mmoh (semifinals) Stefan Kozlov (quarterfinals) Christopher Eubanks (final) Ben Shelton (champion) Emilio Nava (first round) Aleksandar Kovacevic (quarterfinals)
Enzo Couacaud (semifinals)
Shang Juncheng (first round)| Semifinals | Final | ||||||||||||
| 1 | Michael Mmoh | 77 | 5 | 2 | |||||||||
| 3 | Christopher Eubanks | 62 | 7 | 6 | |||||||||
| 3 | Christopher Eubanks | 3 | 6 | 64 | |||||||||
| 4 | Ben Shelton | 6 | 1 | 77 | |||||||||
| 4 | Ben Shelton | 63 | 6 | 6 | |||||||||
| 7 | Enzo Couacaud | 77 | 4 | 4 | |||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | M Mmoh | 6 | 6 | ||||||||||||||||||||||||
| Q | Alexander Bernard | 0 | 0 | 1 | M Mmoh | 7 | 6 | ||||||||||||||||||||
| U Blanch | 6 | 3 | 7 | U Blanch | 5 | 3 | |||||||||||||||||||||
| Q | Tristan McCormick | 3 | 6 | 5 | 1 | M Mmoh | 6 | 6 | |||||||||||||||||||
 A Walton | 4 | 6 | 3 | T Sandgren | 3 | 4 | |||||||||||||||||||||
| Z Svajda | 6 | 4 | 6 | Z Svajda | 1 | 2 | |||||||||||||||||||||
| T Sandgren | 78 | 6 | T Sandgren | 6 | 6 | ||||||||||||||||||||||
| 5 | Em Nava | 66 | 3 | 1 | M Mmoh | 77 | 5 | 2 | |||||||||||||||||||
| 3 | C Eubanks | 6 | 6 | 3 | C Eubanks | 62 | 7 | 6 | |||||||||||||||||||
 N Álvarez Varona | 4 | 2 | 3 | C Eubanks | 77 | 6 | |||||||||||||||||||||
| Q | S Kirchheimer | 6 | 6 | Q | S Kirchheimer | 62 | 4 | ||||||||||||||||||||
| WC | Gage Brymer | 3 | 1 | 3 | C Eubanks | 6 | 6 | ||||||||||||||||||||
 P Jubb | 6 | 3 | 719 |  L Gerch | 3 | 2 | |||||||||||||||||||||
| E Escobedo | 4 | 6 | 617 | P Jubb | 7 | 62 | 4 | ||||||||||||||||||||
| Lucas Gerch | 6 | 77 | L Gerch | 5 | 77 | 6 | |||||||||||||||||||||
| 8 | J Shang | 4 | 63 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 6 | A Kovacevic | 77 | 4 | 77 | |||||||||||||||||||||||
| Alt | E Quinn | 62 | 6 | 65 | 6 | A Kovacevic | 6 | 6 | |||||||||||||||||||
| S Fanselow | 6 | 1 | 4 | Q | I Montes de la Torre | 1 | 4 | ||||||||||||||||||||
| Q | I Montes de la Torre | 3 | 6 | 6 | 6 | A Kovacevic | 5 | 4 | |||||||||||||||||||
| Q | G Hussey | 61 | 1 | 4 | B Shelton | 7 | 6 | ||||||||||||||||||||
| M Krueger | 77 | 6 | M Krueger | 2 | 1 | ||||||||||||||||||||||
| K Smith | 6 | 4 | 3 | 4 | B Shelton | 6 | 6 | ||||||||||||||||||||
| 4 | B Shelton | 4 | 6 | 6 | 4 | B Shelton | 63 | 6 | 6 | ||||||||||||||||||
| 7 | E Couacaud | 77 | 6 | 7 | E Couacaud | 77 | 4 | 4 | |||||||||||||||||||
| Ezekiel Clark | 65 | 3 | 7 | E Couacaud | 6 | 6 | |||||||||||||||||||||
| A McHugh | 6 | 710 | A McHugh | 4 | 2 | ||||||||||||||||||||||
| Q | C Kingsley | 2 | 68 | 7 | E Couacaud | 6 | 7 | ||||||||||||||||||||
 P Gunneswaran | 6 | 6 | 2 | S Kozlov | 3 | 5 | |||||||||||||||||||||
| WC |  B Bicknell | 1 | 2 | P Gunneswaran | 4 | 3 | |||||||||||||||||||||
| WC | M Damm | 79 | 3 | 2 | 2 | S Kozlov | 6 | 6 | |||||||||||||||||||
| 2 | S Kozlov | 67 | 6 | 6 | |||||||||||||||||||||||
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