Sanchai Ratiwatana and Sonchat Ratiwatana were the defending champions but only Sonchat Ratiwatana defended his title, partnering Yi Chu-huan. Ratiwatana lost in the semifinals to Daniel Masur and Ante Pavić.
Brydan Klein and Matt Reid were the defending champions but only Reid defended his title, partnering John-Patrick Smith.
Daniel Masur and Ante Pavić were the defending champions but chose not to defend their title.
David O'Hare and Joe Salisbury were the defending champions but only Salisbury chose to defend his title, partnering Leander Paes. Salisbury lost in the final to Jeevan Nedunchezhiyan and Christopher Rungkat.
Sanchai Ratiwatana and Christopher Rungkat were the defending champions but only Rungkat chose to defend his title, partnering Roberto Maytín. Rungkat lost in the final to Austin Krajicek and Jeevan Nedunchezhiyan.
Kevin Krawietz and Andreas Mies were the defending champions but chose not to defend their title.
Hans Podlipnik Castillo and Andrei Vasilevski were the defending champions but only Vasilevski chose to defend his title, partnering Vladyslav Manafov. Vasilevski lost in the first round to Federico Gaio and Enrique López Pérez.
Lorenzo Giustino and Gonçalo Oliveira were the defending champions but only Oliveira chose to defend his title, partnering Andrei Vasilevski. Oliveira lost in the final to Jurij Rodionov and Emil Ruusuvuori.
Austin Krajicek and Jeevan Nedunchezhiyan were the defending champions but only Nedunchezhiyan chose to defend his title, partnering Purav Raja. Nedunchezhiyan lost in the semifinals to Marcus Daniell and Leander Paes.
Zdeněk Kolář and Lukáš Rosol were the defending champions but only Kolář chose to defend his title, partnering Roman Jebavý. Kolář lost in the final to Aleksandr Nedovyesov and Gonçalo Oliveira.
This was the first edition of the tournament.
Denys Molchanov and Aleksandr Nedovyesov were the defending champions but chose not to defend their title.
Ivan and Matej Sabanov were the defending champions but lost in the quarterfinals to Matteo Arnaldi and Francesco Passaro.
Antonio Šančić and Nino Serdarušić were the defending champions but chose not to defend their title.
The 2022 Lisboa Belém Open was a professional tennis tournament played on outdoor clay courts. It was the sixth (men) and second (women) editions of the tournament which were part of the 2022 ATP Challenger Tour and the 2022 ITF Women's World Tennis Tour. It took place in Lisbon, Portugal between 26 September and 2 October 2022.
Denys Molchanov and David Vega Hernández were the defending champions but chose not to defend their title.
This was the first edition of the tournament.
Sriram Balaji and Jeevan Nedunchezhiyan were the defending champions but chose not to defend their title.
Vladyslav Manafov and Oleg Prihodko were the defending champions but chose not to defend their title.
Vladyslav Manafov and Oleg Prihodko were the defending champions but they chose to defend their title with different partners. Manafov partnered Ivan Liutarevich but lost in the first round to Andrey Golubev and Denys Molchanov. Prihodko partnered Denis Klok but lost in the first round to Viktor Durasovic and Akira Santillan.
Zdeněk Kolář 
Gonçalo Oliveira 
Vladyslav Manafov 
