| Singles | |
|---|---|
| 2022 Monterrey Challenger | |
| Champion |  Fernando Verdasco |
| Runner-up |  Prajnesh Gunneswaran |
| Score | 4–6, 6–3, 7–6(7–3) |
Adrian Mannarino was the defending champion [1] but chose not to defend his title.
Fernando Verdasco won the title after defeating Prajnesh Gunneswaran 4–6, 6–3, 7–6(7–3) in the final.
Fernando Verdasco (champion)
Jay Clarke (second round)
Jason Jung (quarterfinals)
Cedrik-Marcel Stebe (first round)
Juan Pablo Ficovich (second round)
Maxime Janvier (first round) Prajnesh Gunneswaran (final) Geoffrey Blancaneaux (quarterfinals)| Semifinals | Final | ||||||||||||
| 1 | Fernando Verdasco | 4 | 6 | 6 | |||||||||
 Christian Harrison | 6 | 4 | 2 | ||||||||||
| 1 | Fernando Verdasco | 4 | 6 | 77 | |||||||||
| 7 | Prajnesh Gunneswaran | 6 | 3 | 63 | |||||||||
| 7 | Prajnesh Gunneswaran | 67 | 77 | 6 | |||||||||
| PR |  Go Soeda | 79 | 64 | 4 | |||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | F Verdasco | 6 | 6 | ||||||||||||||||||||||||
| PR |  Z Li | 4 | 2 | 1 | F Verdasco | 6 | 6 | ||||||||||||||||||||
| Q | A Kovacevic | 6 | 6 | Q | A Kovacevic | 4 | 2 | ||||||||||||||||||||
| Q | N Nakagawa | 2 | 2 | 1 | F Verdasco | 6 | 6 | ||||||||||||||||||||
| Q | W Blumberg | 6 | 3 | 0 | M Mmoh | 3 | 2 | ||||||||||||||||||||
 R Hijikata | 2 | 6 | 6 | R Hijikata | 77 | 1 | 4 | ||||||||||||||||||||
| M Mmoh | 6 | 6 | M Mmoh | 65 | 6 | 6 | |||||||||||||||||||||
| 6 | M Janvier | 4 | 4 | 1 | F Verdasco | 4 | 6 | 6 | |||||||||||||||||||
| 4 | C-M Stebe | 2 | 2 | C Harrison | 6 | 4 | 2 | ||||||||||||||||||||
| B Tomic | 6 | 6 | B Tomic | 2 | 5 | ||||||||||||||||||||||
| Q | S Shimabukuro | 3 | 5 | C Harrison | 6 | 7 | |||||||||||||||||||||
| C Harrison | 6 | 7 | C Harrison | 6 | 6 | ||||||||||||||||||||||
| K Uchida | 3 | 3 | 8 | G Blancaneaux | 4 | 2 | |||||||||||||||||||||
| T Robredo | 6 | 6 | T Robredo | 3 | 1 | ||||||||||||||||||||||
| WC |  A Hernández | 2 | 6 | 4 | 8 | G Blancaneaux | 6 | 6 | |||||||||||||||||||
| 8 | G Blancaneaux | 6 | 2 | 6 | |||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 7 | P Gunneswaran | 6 | 6 | ||||||||||||||||||||||||
| WC | R Harrison | 3 | 4 | 7 | P Gunneswaran | 77 | 6 | ||||||||||||||||||||
| A Rybakov | 7 | 6 | A Rybakov | 61 | 1 | ||||||||||||||||||||||
| PR |  R Statham | 5 | 3 | 7 | P Gunneswaran | 1 | 7 | 6 | |||||||||||||||||||
| Q | E Zhu | 6 | 6 | 3 | J Jung | 6 | 5 | 4 | |||||||||||||||||||
| WC | Milledge Cossu | 1 | 2 | Q | E Zhu | 2 | 5 | ||||||||||||||||||||
| Q | S Kirchheimer | 4 | 1 | 3 | J Jung | 6 | 7 | ||||||||||||||||||||
| 3 | J Jung | 6 | 6 | 7 | P Gunneswaran | 67 | 77 | 6 | |||||||||||||||||||
| 5 | JP Ficovich | 6 | 7 | PR | G Soeda | 79 | 64 | 4 | |||||||||||||||||||
 P Krstin | 2 | 5 | 5 | JP Ficovich | 6 | 2 | 2 | ||||||||||||||||||||
 V Durasovic | 2 | 77 | 3 | PR | G Soeda | 2 | 6 | 6 | |||||||||||||||||||
| PR | G Soeda | 6 | 60 | 6 | PR | G Soeda | 4 | 77 | 6 | ||||||||||||||||||
| PR | U Blanch | 6 | 4 | 6 | PR | U Blanch | 6 | 65 | 4 | ||||||||||||||||||
| J Lenz | 3 | 6 | 2 | PR | U Blanch | 77 | 6 | ||||||||||||||||||||
| T-l Wu | 4 | 3 | 2 | J Clarke | 64 | 2 | |||||||||||||||||||||
| 2 | J Clarke | 6 | 6 | ||||||||||||||||||||||||
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