| Singles | |
|---|---|
| 2022 Open Harmonie mutuelle | |
| Champion |  Jack Draper |
| Runner-up |  Zizou Bergs |
| Score | 6–2, 5–7, 6–4 |
Kamil Majchrzak was the defending champion [1] but chose not to defend his title.
Jack Draper won the title after defeating Zizou Bergs 6–2, 5–7, 6–4 in the final.
Ričardas Berankis (withdrew)
Quentin Halys (semifinals) Gilles Simon (first round)
Roman Safiullin (second round, withdrew) Jack Draper (champion) Grégoire Barrère (first round) Constant Lestienne (first round, retired) Antoine Hoang (second round)| Semifinals | Final | ||||||||||||
| Antoine Escoffier | 2 | 6 | 0 | ||||||||||
| 5 | Jack Draper | 6 | 0 | 6 | |||||||||
| 5 | Jack Draper | 6 | 5 | 6 | |||||||||
| Q | Zizou Bergs | 2 | 7 | 4 | |||||||||
| Q | Zizou Bergs | 3 | 6 | 6 | |||||||||
| 2 | Quentin Halys | 6 | 3 | 1 | |||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| LL |  M Rosenkranz | 6 | 77 | ||||||||||||||||||||||||
 G Soeda | 2 | 64 | LL | M Rosenkranz | 5 | 1 | |||||||||||||||||||||
| A Escoffier | 77 | 77 | A Escoffier | 7 | 6 | ||||||||||||||||||||||
| M Janvier | 62 | 64 | A Escoffier | 6 | 1 | 6 | |||||||||||||||||||||
| Q |  F Marozsán | 3 | 4 | R Peniston | 2 | 6 | 1 | ||||||||||||||||||||
| R Peniston | 6 | 6 | R Peniston | 6 | 66 | 6 | |||||||||||||||||||||
| WC | L Van Assche | 77 | 2 | 4 | 8 | A Hoang | 1 | 78 | 3 | ||||||||||||||||||
| 8 | A Hoang | 65 | 6 | 6 | A Escoffier | 2 | 6 | 0 | |||||||||||||||||||
| 3 | G Simon | 77 | 65 | 5 | 5 | J Draper | 6 | 0 | 6 | ||||||||||||||||||
| E Karlovskiy | 65 | 77 | 7 | E Karlovskiy | 4 | 5 | |||||||||||||||||||||
| E Furness | 6 | 6 | E Furness | 6 | 7 | ||||||||||||||||||||||
 J Sels | 3 | 2 | E Furness | 2 | 1 | ||||||||||||||||||||||
| R Haase | 7 | 7 | 5 | J Draper | 6 | 6 | |||||||||||||||||||||
| WC | A Fils | 5 | 5 | R Haase | 2 | 3 | |||||||||||||||||||||
 I Marchenko | 3 | 63 | 5 | J Draper | 6 | 6 | |||||||||||||||||||||
| 5 | J Draper | 6 | 77 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 7 | C Lestienne | 2r | |||||||||||||||||||||||||
| LL | B Hassan | 3 | LL | B Hassan | 7 | 3 | 6 | ||||||||||||||||||||
| Alt |  M Jaziri | 1 | 3 | H Moriya | 5 | 6 | 4 | ||||||||||||||||||||
| H Moriya | 6 | 6 | LL | B Hassan | |||||||||||||||||||||||
| Q | Z Bergs | 6 | 6 | Q | Z Bergs | w/o | |||||||||||||||||||||
| LL |  M Pervolarakis | 3 | 1 | Q | Z Bergs | w/o | |||||||||||||||||||||
| Q |  A Galarneau | 65 | 62 | 4 | R Safiullin | ||||||||||||||||||||||
| 4 | R Safiullin | 77 | 77 | Q | Z Bergs | 3 | 6 | 6 | |||||||||||||||||||
| 6 | G Barrère | 4 | 2 | 2 | Q Halys | 6 | 3 | 1 | |||||||||||||||||||
 B Gojo | 6 | 6 | B Gojo | 1 | 66 | ||||||||||||||||||||||
| WC | H Mayot | 3 | 6 | 4 | Q | A Gray | 6 | 78 | |||||||||||||||||||
| Q | A Gray | 6 | 4 | 6 | Q | A Gray | 3 | 5 | |||||||||||||||||||
| Alt |  M Torpegaard | 6 | 69 | 3 | 2 | Q Halys | 6 | 7 | |||||||||||||||||||
| Q | H Squire | 4 | 711 | 6 | Q | H Squire | 4 | 62 | |||||||||||||||||||
| T Lamasine | 2 | 2 | 2 | Q Halys | 6 | 77 | |||||||||||||||||||||
| 2 | Q Halys | 6 | 6 | ||||||||||||||||||||||||
Kamil Majchrzak and Martin Redlicki were the defending champions, having won the event in 2013. However, neither participated in the 2014 event; Redlicki's age by the 2014 event's qualifying cutoff made him ineligible to continue to participate in junior events and Majchrzak chose not to participate.
Guillermo García López was the defending champion but chose not to defend his title.
Stefan Kozlov was the defending champion but lost in the first round to Kamil Majchrzak.
Mirza Bašić was the defending champion but lost in the first round to Martin Kližan.
Ričardas Berankis was the defending champion but lost in the semifinals to Kamil Majchrzak.
Bernard Tomic was the defending champion, but retired in the first round of the qualifying tournament against Denis Istomin.
Kamil Majchrzak was the defending champion but chose not to defend his title.
Botic van de Zandschulp was the defending champion but withdrew before his semifinal match against Taro Daniel.
Benoît Paire was the defending champion from when the event was last held in 2019, but chose to participate in Geneva instead.
Nikola Milojević was the defending champion but lost in the second round to Tomáš Macháč.
Jozef Kovalík was the defending champion but chose not to defend his title.
Jannik Sinner was the defending champion and successfully defended his title, defeating Gaël Monfils in the final, 6–3, 6–4.
Pavel Kotov was the defending champion but chose not to defend his title.
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Juan Manuel Cerúndolo was the defending champion but chose not to defend his title.
Defending champion Matteo Berrettini defeated Filip Krajinović in the final, 7–5, 6–4 to win the singles tennis title at the 2022 Queen's Club Championships and successfully defend his title. By winning his fourth title on grass and seventh career ATP Tour singles title overall, Berrettini became the first player in the Open Era to claim the title in their first two appearances at the tournament. Krajinović had never earned a tour-level win on grass before the tournament and was contesting for his first career title in his fifth final.
Alex de Minaur defeated Jenson Brooksby in the final, 6–3, 6–3 to win the singles title at the 2022 Atlanta Open. It was de Minaur's second Atlanta title, the first being in 2019.
Adrian Mannarino defeated Laslo Đere in the final, 7–6(7–1), 6–4 to win the singles tennis title at the 2022 Winston-Salem Open. Mannarino saved four match points en route to the title, in his first-round match against Christopher O'Connell.
Marc-Andrea Hüsler defeated Holger Rune in the final, 6–4, 7–6(10–8) to win the singles tennis title at the 2022 Sofia Open. It was his maiden ATP Tour title, and he saved two match points en route, in his quarterfinal match against Kamil Majchrzak. Hüsler became the fourth Swiss man, after Roger Federer, Stan Wawrinka and Marc Rosset, to win an ATP Tour title in the 21st century.
Ričardas Berankis was the defending champion but chose not to defend his title.