Anastasia Potapova won the title, defeating Dayana Yastremska in the final, 6–4, 6–3.
Dalma Gálfi and Fanny Stollár were the defending champions, but chose not to participate this year.
Anastasia Potapova was the defending champion, but chose to compete in the Ladies' Singles main draw as a qualifier, where she retired in the first round against Tatjana Maria.
Magdaléna Rybáriková was the defending champion, but chose not to participate.
Olga Danilović and Marta Kostyuk were the defending champions, but both players chose not to participate.
Eri Hozumi and Moyuka Uchijima were the defending champions but chose to participate with different partners. Hozumi partnered Mana Ayukawa, but lost in the first round to Wu Fang-hsien and Zhang Ying.
Zhang Shuai defeated wildcard Dayana Yastremska in the final, 3–6, 6–3, 6–4 to win the Singles title at the 2022 WTA Lyon Open. It was her first title since 2017. Yastremska was participating in her first event since fleeing her native country of Ukraine due to the 2022 Russian invasion of Ukraine.
Peangtarn Plipuech and Jessy Rompies were the defending champions but Rompies chose not to participate.
Indy de Vroome was the defending champion but chose not to participate.
Zhang Shuai was the four-time defending champion but chose not to participate.
Sophie Chang and Anna Danilina were the defending champions but Danilina chose to compete at the 2023 National Bank Open instead. Chang partnered alongside Yulia Starodubtseva, and won the tournament after Olivia Gadecki and Mai Hontama withdrew from the final.
Hsieh Yu-chieh and Jessy Rompies were the defending champions but Hsieh chose not to participate. Rompies partnered alongside Beatrice Gumulya, but they lost in the quarterfinals to Wang Xiyu and Yuan Yue.
Mai Hontama was the defending champion but chose not to participate.
Lizette Cabrera and Jang Su-jeong were the defending champions but chose not to participate.
Nuria Brancaccio and Lisa Pigato were the defending champions but Brancaccio chose not to participate. Pigato intended to partner alongside Georgia Pedone, but withdrew before their first round match with Yuliana Lizarazo and María Paulina Pérez.
Ángela Fita Boluda was the defending champion but lost in the semifinals to Yuliya Hatouka.
Viktorija Golubic was the defending champion but chose not to participate.
Jessika Ponchet and Bibiane Schoofs were the defending champions but Ponchet chose to participate in Madrid, while Schoofs competed in Oeiras.
Himeno Sakatsume was the defending champion but chose to compete in Wiesbaden instead.
Yanina Wickmayer was the defending champion but chose not to participate.
Yvonne Cavallé Reimers 
Aurora Zantedeschi 
Zhibek Kulambayeva 
Ekaterina Reyngold 
