AADAC

AADAC
Identifiers
Aliases	AADAC , CES5A1, DAC, arylacetamide deacetylase
External IDs	OMIM: 600338 MGI: 1915008 HomoloGene: 37436 GeneCards: AADAC
EC number	3.1.1.3
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q25.1 Start 151,814,073 bp [1] End 151,828,488 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 D Start 60,025,717 bp [2] End 60,040,160 bp [2]
RNA expression pattern Bgee Top expressed in liver jejunal mucosa small intestine duodenum adrenal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function serine hydrolase activity GO:0004091 carboxylic ester hydrolase activity catalytic activity hydrolase activity lipase activity deacetylase activity triglyceride lipase activity Cellular component organelle membrane integral component of membrane endoplasmic reticulum membrane endoplasmic reticulum membrane intracellular membrane-bounded organelle Biological process xenobiotic metabolic process metabolism positive regulation of triglyceride catabolic process catabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	13	67758
Ensembl	ENSG00000114771	ENSMUSG00000027761
UniProt	P22760	Q99PG0
RefSeq (mRNA)	NM_001086	NM_023383
RefSeq (protein)	NP_001077	NP_075872
Location (UCSC)	Chr 3: 151.81 – 151.83 Mb	Chr 3: 60.03 – 60.04 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Arylacetamide deacetylase is an enzyme that in humans is encoded by the AADAC gene. ^{[5] [6]}

Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000114771 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027761 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Probst MR, Beer M, Beer D, Jeno P, Meyer UA, Gasser R (Sep 1994). "Human liver arylacetamide deacetylase. Molecular cloning of a novel esterase involved in the metabolic activation of arylamine carcinogens with high sequence similarity to hormone-sensitive lipase". J Biol Chem. 269 (34): 21650–6. doi: 10.1016/S0021-9258(17)31855-0 . PMID   8063807.
6. "Entrez Gene: AADAC arylacetamide deacetylase (esterase)".

Further reading

• Probst MR, Jenö P, Meyer UA (1991). "Purification and characterization of a human liver arylacetamide deacetylase". Biochem. Biophys. Res. Commun. 177 (1): 453–9. doi:10.1016/0006-291X(91)92005-5. PMID   2043131.
• Yamazaki K, Kusano K, Tadano K, Tanaka I (1997). "Radiation hybrid mapping of human arylacetamide deacetylase (AADAC) locus to chromosome 3". Genomics. 44 (2): 248–50. doi:10.1006/geno.1997.4879. PMID   9299245.
• Ozols J (1998). "Determination of lumenal orientation of microsomal 50-kDa esterase/N-deacetylase". Biochemistry. 37 (28): 10336–44. doi:10.1021/bi9807916. PMID   9665742.
• Mziaut H, Korza G, Hand AR, et al. (1999). "Targeting proteins to the lumen of endoplasmic reticulum using N-terminal domains of 11beta-hydroxysteroid dehydrogenase and the 50-kDa esterase". J. Biol. Chem. 274 (20): 14122–9. doi: 10.1074/jbc.274.20.14122 . PMID   10318829.
• Trickett JI, Patel DD, Knight BL, et al. (2001). "Characterization of the rodent genes for arylacetamide deacetylase, a putative microsomal lipase, and evidence for transcriptional regulation". J. Biol. Chem. 276 (43): 39522–32. doi: 10.1074/jbc.M101764200 . PMID   11481320.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Saito S, Iida A, Sekine A, et al. (2003). "Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population". J. Hum. Genet. 48 (5): 249–70. doi: 10.1007/s10038-003-0021-7 . PMID   12721789.
• Frick C, Atanasov AG, Arnold P, et al. (2004). "Appropriate function of 11beta-hydroxysteroid dehydrogenase type 1 in the endoplasmic reticulum lumen is dependent on its N-terminal region sharing similar topological determinants with 50-kDa esterase". J. Biol. Chem. 279 (30): 31131–8. doi: 10.1074/jbc.M313666200 . PMID   15152005.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.

External links

• AADAC human gene location in the UCSC Genome Browser .
• AADAC human gene details in the UCSC Genome Browser .