AADAT

AADAT
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2QLR, 2R2N, 2VGZ, 2XH1, 3DC1, 3UE8, 4GDY, 4GE4, 4GE7, 4GE9, 4GEB, 5EUN, 5EFS
Identifiers
Aliases	AADAT , KAT2, KATII, KYAT2, aminoadipate aminotransferase
External IDs	OMIM: 611754; MGI: 1345167; HomoloGene: 56540; GeneCards: AADAT; OMA:AADAT - orthologs
EC number	2.6.1.39
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4q33 Start 170,060,222 bp [1] End 170,091,699 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8 B3.1|8 30.85 cM Start 60,958,966 bp [2] End 60,998,711 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver gonad testicle body of uterus canal of the cervix ganglionic eminence ventricular zone right coronary artery endometrium smooth muscle tissue Top expressed in right kidney proximal tubule human kidney left lobe of liver yolk sac renal pelvis otic vesicle embryo renal calyx proximal straight tubule More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity pyridoxal phosphate binding kynurenine-oxoglutarate transaminase activity 2-aminoadipate transaminase activity catalytic activity protein homodimerization activity transaminase activity Cellular component mitochondrial matrix mitochondrion Biological process L-lysine catabolic process to acetyl-CoA via saccharopine tryptophan catabolic process glutamate metabolic process biosynthesis 2-oxoglutarate metabolic process lysine catabolic process kynurenine metabolic process L-kynurenine metabolic process alpha-amino acid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51166 23923 Ensembl ENSG00000109576 ENSMUSG00000057228 UniProt Q8N5Z0 Q9WVM8 RefSeq (mRNA) NM_001286682 NM_001286683 NM_016228 NM_182662 NM_011834 RefSeq (protein) NP_001273611 NP_001273612 NP_057312 NP_872603 NP_035964 Location (UCSC) Chr 4: 170.06 – 170.09 Mb Chr 8: 60.96 – 61 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial, also known as alpha-aminoadipate aminotransferase and kynurenine aminotransferase 2, is a mitochondrial enzyme that in humans is encoded by the AADAT gene. It converts alpha-aminoadipate to alpha-ketoadipate. It is also one of the kynurenine—oxoglutarate transaminases. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000109576 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000057228 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Goh DL, Patel A, Thomas GH, Salomons GS, Schor DS, Jakobs C, Geraghty MT (July 2002). "Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT)". Molecular Genetics and Metabolism. 76 (3): 172–80. doi:10.1016/s1096-7192(02)00037-9. PMID   12126930.

External links

• Human AADAT genome location and AADAT gene details page in the UCSC Genome Browser .
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial (AADAT)