AADAT

AADAT
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2QLR, 2R2N, 2VGZ, 2XH1, 3DC1, 3UE8, 4GDY, 4GE4, 4GE7, 4GE9, 4GEB, 5EUN, 5EFS
Identifiers
Aliases	AADAT , KAT2, KATII, KYAT2, aminoadipate aminotransferase
External IDs	OMIM: 611754 MGI: 1345167 HomoloGene: 56540 GeneCards: AADAT
EC number	2.6.1.39
Gene location (Human)
Chr.	Chromosome 4 (human) [1]
End	170,091,699 bp [1]
Gene location (Mouse)
Chr.	Chromosome 8 (mouse) [2]
End	60,545,677 bp [2]
Gene ontology
Molecular function	• transferase activity ; • pyridoxal phosphate binding ; • kynurenine-oxoglutarate transaminase activity ; • 2-aminoadipate transaminase activity ; • catalytic activity ; • protein homodimerization activity ; • transaminase activity ;
Cellular component	• mitochondrial matrix ; • mitochondrion ;
Biological process	• L-lysine catabolic process to acetyl-CoA via saccharopine ; • tryptophan catabolic process ; • glutamate metabolic process ; • biosynthetic process ; • 2-oxoglutarate metabolic process ; • lysine catabolic process ; • kynurenine metabolic process ; • L-kynurenine metabolic process ; • alpha-amino acid metabolic process ;
	Sources:Amigo / QuickGO
Orthologs
	51166
	23923
	ENSG00000109576
	ENSMUSG00000057228
	Q8N5Z0
	Q9WVM8
	NM_001286682 ; NM_001286683 ; NM_016228 ; NM_182662
	NM_011834
	NP_001273611 ; NP_001273612 ; NP_057312 ; NP_872603
	NP_035964
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 30, 2019

Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial, also known as alpha-aminoadipate aminotransferase and kynurenine aminotransferase 2, is a mitochondrial enzyme that in humans is encoded by the AADAT gene. It converts alpha-aminoadipate to alpha-ketoadipate. It is also one of the Kynurenine—oxoglutarate transaminases.^[5]

Enzymes are macromolecular biological catalysts that accelerate chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. Almost all metabolic processes in the cell need enzyme catalysis in order to occur at rates fast enough to sustain life. Metabolic pathways depend upon enzymes to catalyze individual steps. The study of enzymes is called enzymology and a new field of pseudoenzyme analysis has recently grown up, recognising that during evolution, some enzymes have lost the ability to carry out biological catalysis, which is often reflected in their amino acid sequences and unusual 'pseudocatalytic' properties.

In enzymology, a kynurenine-oxoglutarate transaminase is an enzyme that catalyzes the chemical reaction

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000109576 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000057228 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Goh DL, Patel A, Thomas GH, Salomons GS, Schor DS, Jakobs C, Geraghty MT (July 2002). "Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT)". Molecular Genetics and Metabolism. 76 (3): 172–80. doi:10.1016/s1096-7192(02)00037-9. PMID 12126930.

External links

Human AADAT genome location and AADAT gene details page in the UCSC Genome Browser .
PDBe-KB provides an overview of all the structure information available in the PDB for Human Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial (AADAT)

The UCSC Genome Browser is an on-line, and downloadable, genome browser hosted by the University of California, Santa Cruz (UCSC). It is an interactive website offering access to genome sequence data from a variety of vertebrate and invertebrate species and major model organisms, integrated with a large collection of aligned annotations. The Browser is a graphical viewer optimized to support fast interactive performance and is an open-source, web-based tool suite built on top of a MySQL database for rapid visualization, examination, and querying of the data at many levels. The Genome Browser Database, browsing tools, downloadable data files, and documentation can all be found on the UCSC Genome Bioinformatics website.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000109576 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000057228 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Goh DL, Patel A, Thomas GH, Salomons GS, Schor DS, Jakobs C, Geraghty MT (July 2002). "Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT)". Molecular Genetics and Metabolism. 76 (3): 172–80. doi:10.1016/s1096-7192(02)00037-9. PMID 12126930.