ACP2

ACP2
Identifiers
Aliases	ACP2 , acid phosphatase 2, lysosomal, LAP
External IDs	OMIM: 171650 MGI: 87882 HomoloGene: 1217 GeneCards: ACP2
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p11.2|11p12-p11 Start 47,239,302 bp [1] End 47,248,906 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2 E1|2 50.54 cM Start 91,033,230 bp [2] End 91,044,443 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver body of pancreas right adrenal gland left adrenal gland stromal cell of endometrium jejunal mucosa salivary gland duodenum body of stomach spleen Top expressed in spermatocyte medial dorsal nucleus spermatid medial geniculate nucleus ascending aorta aortic valve superior frontal gyrus lateral geniculate nucleus subiculum olfactory epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function hydrolase activity acid phosphatase activity Cellular component integral component of membrane lysosomal membrane lysosome lysosomal lumen extracellular exosome membrane Biological process skeletal system development lysosome organization dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 53 11432 Ensembl ENSG00000134575 ENSMUSG00000002103 UniProt P11117 P24638 RefSeq (mRNA) NM_001131064 NM_001302489 NM_001302490 NM_001302491 NM_001302492 NM_001610 NM_001357016 NM_007387 NM_001357067 RefSeq (protein) NP_001289418 NP_001289419 NP_001289420 NP_001289421 NP_001601 NP_001343945 NP_031413 NP_001343996 Location (UCSC) Chr 11: 47.24 – 47.25 Mb Chr 2: 91.03 – 91.04 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Lysosomal acid phosphatase is an enzyme that in humans is encoded by the ACP2 gene. ^{[5] [6]}

Lysosomal acid phosphatase is composed of two subunits, alpha and beta, and is chemically and genetically distinct from red cell acid phosphatase. Lysosomal acid phosphatase 2 is a member of a family of distinct isoenzymes which hydrolyze orthophosphoric monoesters to alcohol and phosphate. Acid phosphatase deficiency is caused by mutations in the ACP2 (beta subunit) and ACP3 (alpha subunit) genes. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000134575 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000002103 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Shows TB, Brown JA, Lalley PA (Dec 1976). "Assignment and linear order of human acid phosphatase-2, esterase A4, and lactate dehydrogenase A genes on chromosome 11". Cytogenet Cell Genet. 16 (1–5): 231–4. doi:10.1159/000130598. PMID   975882.
6. "Entrez Gene: ACP2 acid phosphatase 2, lysosomal".

Further reading

• Moss DW, Raymond FD, Wile DB (1995). "Clinical and biological aspects of acid phosphatase". Critical Reviews in Clinical Laboratory Sciences. 32 (4): 431–67. doi:10.3109/10408369509084690. PMID   7576159.
• Gierek T, Lisiewicz T, Pilch J (1977). "Intracellular enzymatic response of lymphocytes and neutrophils in patients with cancer of the larynx". Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. 104 (2): 208–15. PMID   69583.
• Jones C, Kao FT (1979). "Regional mapping of the gene for human lysosomal acid phosphatase (ACP2) using a hybrid clone panel containing segments of human chromosome 11". Hum. Genet. 45 (1): 1–10. doi:10.1007/BF00277567. PMID   730175. S2CID   21173503.
• Geier C, von Figura K, Pohlmann R (1989). "Structure of the human lysosomal acid phosphatase gene". Eur. J. Biochem. 183 (3): 611–6. doi: 10.1111/j.1432-1033.1989.tb21090.x . PMID   2776754.
• Lemansky P, Gieselmann V, Hasilik A, von Figura K (1985). "Synthesis and transport of lysosomal acid phosphatase in normal and I-cell fibroblasts". J. Biol. Chem. 260 (15): 9023–30. doi: 10.1016/S0021-9258(17)39452-8 . PMID   3160696.
• Pohlmann R, Krentler C, Schmidt B, et al. (1989). "Human lysosomal acid phosphatase: cloning, expression and chromosomal assignment". EMBO J. 7 (8): 2343–50. doi:10.1002/j.1460-2075.1988.tb03078.x. PMC   457099 . PMID   3191910.
• Waheed A, Van Etten RL (1985). "Biosynthesis and processing of lysosomal acid phosphatase in cultured human cells". Arch. Biochem. Biophys. 243 (1): 274–83. doi:10.1016/0003-9861(85)90796-9. PMID   3904632.
• Nadler HL, Egan TJ (1970). "Deficiency of lysosomal acid phosphatase. A new familial metabolic disorder". N. Engl. J. Med. 282 (6): 302–7. doi:10.1056/NEJM197002052820604. PMID   5410815.
• Bass DA, Lewis JC, Szejda P, et al. (1981). "Activation of lysosomal acid phosphatase of eosinophil leukocytes". Lab. Invest. 44 (5): 403–9. PMID   6164873.
• Chappard D, Alexandre C, Riffat G (1983). "Histochemical identification of osteoclasts. Review of current methods and reappraisal of a simple procedure for routine diagnosis on undecalcified human iliac bone biopsies". Basic and Applied Histochemistry. 27 (2): 75–85. PMID   6193776.
• Moszczyński P, Lisiewicz J (1984). "Beta-glucuronidase of lymphocytes in ontogenetic development of man". Arch. Immunol. Ther. Exp. (Warsz.). 31 (2): 171–6. PMID   6651479.
• Radzun HJ, Parwaresch MR (1981). "Isoelectric focusing pattern of acid phosphatase and acid esterase in human blood cells, including thymocytes, T lymphocytes, and B lymphocytes". Exp. Hematol. 8 (6): 737–41. PMID   6970673.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
• Whitelock RB, Fukuchi T, Zhou L, et al. (1997). "Cathepsin G, acid phosphatase, and alpha 1-proteinase inhibitor messenger RNA levels in keratoconus corneas". Invest. Ophthalmol. Vis. Sci. 38 (2): 529–34. PMID   9040486.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Obermüller S, Kiecke C, von Figura K, Höning S (2002). "The tyrosine motifs of Lamp 1 and LAP determine their direct and indirect targeting to lysosomes". J. Cell Sci. 115 (Pt 1): 185–94. doi: 10.1242/jcs.115.1.185 . PMID   11801736.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.

External links

• Human ACP2 genome location and ACP2 gene details page in the UCSC Genome Browser .