ACSM2B

ACSM2B
Identifiers
Aliases	ACSM2B , ACSM2, HXMA, HYST1046, acyl-CoA synthetase medium-chain family member 2B, acyl-CoA synthetase medium chain family member 2B
External IDs	OMIM: 614359 HomoloGene: 89289 GeneCards: ACSM2B
Gene location (Human)
Chr.	Chromosome 16 (human)
End	20,576,427 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; kidney; ; renal cortex; ; sural nerve; ; left uterine tube; ; renal medulla; ; right lobe of thyroid gland; ; body of pancreas; ; left lobe of thyroid gland; ; right adrenal gland;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding ; ligase activity ; catalytic activity ; ATP binding ; metal ion binding ; butyrate-CoA ligase activity ; CoA-ligase activity ; fatty-acyl-CoA synthase activity ; fatty acid ligase activity ; molecular function ;
Cellular component	mitochondrion ; mitochondrial matrix ;
Biological process	xenobiotic metabolic process ; metabolism ; fatty acid metabolic process ; lipid metabolism ; fatty acid biosynthetic process ; acyl-CoA metabolic process ;
	Sources:Amigo / QuickGO
Orthologs
	348158
	n/a
	ENSG00000066813
	n/a
	Q68CK6
	n/a
	NM_001105069 ; NM_182617
	n/a
	NP_001098539 ; NP_872423
	n/a
	Wikidata
View/Edit Human

Last updated July 23, 2023

Acyl-coenzyme A synthetase ACSM2B, mitochondrial is an enzyme that in humans is encoded by the ACSM2B gene.^[3]^[4]

Related Research Articles

<span class="mw-page-title-main">Enoyl CoA isomerase</span>

Enoyl-CoA-(∆) isomerase (EC 5.3.3.8, also known as dodecenoyl-CoA- isomerase, 3,2-trans-enoyl-CoA isomerase, ∆3 ,∆2 -enoyl-CoA isomerase, or acetylene-allene isomerase, is an enzyme that catalyzes the conversion of cis- or trans-double bonds of coenzyme A bound fatty acids at gamma-carbon to trans double bonds at beta-carbon as below:

ACADM is a gene that provides instructions for making an enzyme called acyl-coenzyme A dehydrogenase that is important for breaking down (degrading) a certain group of fats called medium-chain fatty acids.

Triacsin C is an inhibitor of long fatty acyl CoA synthetase that has been isolated from Streptomyces aureofaciens. It blocks β-cell apoptosis, induced by fatty acids (lipoapoptosis) in a rat model of obesity. In addition, it blocks the de novo synthesis of triglycerides, diglycerides, and cholesterol esters, thus interfering with lipid metabolism.

Acyl-CoA dehydrogenases (ACADs) are a class of enzymes that function to catalyze the initial step in each cycle of fatty acid β-oxidation in the mitochondria of cells. Their action results in the introduction of a trans double-bond between C2 (α) and C3 (β) of the acyl-CoA thioester substrate. Flavin adenine dinucleotide (FAD) is a required co-factor in addition to the presence of an active site glutamate in order for the enzyme to function.

<span class="mw-page-title-main">Acyl-CoA</span>

Acyl-CoA is a group of coenzymes that metabolize fatty acids. Acyl-CoA's are susceptible to beta oxidation, forming, ultimately, acetyl-CoA. The acetyl-CoA enters the citric acid cycle, eventually forming several equivalents of ATP. In this way, fats are converted to ATP, the universal biochemical energy carrier.

Palmitoyl-CoA is an acyl-CoA thioester. It is an "activated" form of palmitic acid and can be transported into the mitochondrial matrix by the carnitine shuttle system, and once inside can participate in beta-oxidation. Alternatively, palmitoyl-CoA is used as a substrate in the biosynthesis of sphingosine.

The long chain fatty acyl-CoA ligase is an enzyme of the ligase family that activates the oxidation of complex fatty acids. Long chain fatty acyl-CoA synthetase catalyzes the formation of fatty acyl-CoA by a two-step process proceeding through an adenylated intermediate. The enzyme catalyzes the following reaction,

Acyl-CoA synthetase long-chain family member 6 is an enzyme that in humans is encoded by the ACSL6 gene. Long-chain acyl-CoA synthetases such as ACSL6, catalyze the formation of acyl-CoA from fatty acids, ATP, and CoA.

Butyrate—CoA ligase, also known as xenobiotic/medium-chain fatty acid-ligase (XM-ligase), is an enzyme that catalyzes the chemical reaction:

In enzymology, a bile acid-CoA:amino acid N-acyltransferase is an enzyme that catalyzes the chemical reaction

Long-chain-fatty-acid—CoA ligase 1 is an enzyme that in humans is encoded by the ACSL1 gene.

Long-chain-fatty-acid—CoA ligase 5 is an enzyme that in humans is encoded by the ACSL5 gene.

Long-chain-fatty-acid—CoA ligase 3 is an enzyme that in humans is encoded by the ACSL3 gene.

Long-chain-fatty-acid—CoA ligase 4 is an enzyme that in humans is encoded by the ACSL4 gene.

Very long-chain acyl-CoA synthetase is an enzyme that in humans is encoded by the SLC27A2 gene.

Glycine-N-acyltransferase, also known as GLYAT, is an enzyme which in humans is encoded by the GLYAT gene.

Bile acyl-CoA synthetase is an enzyme that in humans is encoded by the SLC27A5 gene.

Long-chain fatty acid transport protein 6 is a protein that in humans is encoded by the SLC27A6 gene.

Glycine N-phenylacetyltransferase is an enzyme with systematic name phenylacetyl-CoA:glycine N-phenylacetyltransferase. This enzyme catalyses the following chemical reaction

Acyl-CoA synthetase medium chain family member 2A is a protein that in humans is encoded by the ACSM2A gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000066813 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Vessey DA, Lau E, Kelley M, Warren RS (Mar 2003). "Isolation, sequencing, and expression of a cDNA for the HXM-A form of xenobiotic/medium-chain fatty acid:CoA ligase from human liver mitochondria". J Biochem Mol Toxicol. 17 (1): 1–6. doi:10.1002/jbt.10056. PMID 12616642. S2CID 13396633.
↑ "Entrez Gene: ACSM2 acyl-CoA synthetase medium-chain family member 2".

External links

Human ACSM2B genome location and ACSM2B gene details page in the UCSC Genome Browser .

Lindner I, Rubin D, Helwig U, et al. (2006). "The L513S polymorphism in medium-chain acyl-CoA synthetase 2 (MACS2) is associated with risk factors of the metabolic syndrome in a Caucasian study population". Mol Nutr Food Res. 50 (3): 270–4. doi:10.1002/mnfr.200500241. PMID 16521160.
Yamada S, Ohira M, Horie H, et al. (2004). "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas". Oncogene. 23 (35): 5901–11. doi: 10.1038/sj.onc.1207782 . PMID 15221005.
Vessey DA, Kelley M, Warren RS (2004). "Characterization of triacsin C inhibition of short-, medium-, and long-chain fatty acid: CoA ligases of human liver". J. Biochem. Mol. Toxicol. 18 (2): 100–6. doi:10.1002/jbt.20009. PMID 15122652. S2CID 8154380.
Vessey DA, Kelley M (2001). "Characterization of the reaction mechanism for the XL-I form of bovine liver xenobiotic/medium-chain fatty acid:CoA ligase". Biochem. J. 357 (Pt 1): 283–8. doi:10.1042/0264-6021:3570283. PMC 1221953 . PMID 11415461.
Vessey DA, Kelley M, Warren RS (1999). "Characterization of the CoA ligases of human liver mitochondria catalyzing the activation of short- and medium-chain fatty acids and xenobiotic carboxylic acids". Biochim. Biophys. Acta. 1428 (2–3): 455–62. doi:10.1016/s0304-4165(99)00088-4. PMID 10434065.
Vessey DA, Hu J (1997). "Isolation from bovine liver mitochondria and characterization of three distinct carboxylic acid: CoA ligases with activity toward xenobiotics". J. Biochem. Toxicol. 10 (6): 329–37. doi:10.1002/jbt.2570100608. PMID 8934636.
Vessey DA, Hu J, Kelley M (1997). "Interaction of salicylate and ibuprofen with the carboxylic acid: CoA ligases from bovine liver mitochondria". J. Biochem. Toxicol. 11 (2): 73–8. doi:10.1002/(SICI)1522-7146(1996)11:2<73::AID-JBT4>3.0.CO;2-R. PMID 8884467.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000066813 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12616642-3] Vessey DA, Lau E, Kelley M, Warren RS (Mar 2003). "Isolation, sequencing, and expression of a cDNA for the HXM-A form of xenobiotic/medium-chain fatty acid:CoA ligase from human liver mitochondria". J Biochem Mol Toxicol. 17 (1): 1–6. doi:10.1002/jbt.10056. PMID 12616642. S2CID 13396633.

[entrez-4] "Entrez Gene: ACSM2 acyl-CoA synthetase medium-chain family member 2".

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ACSM2B

Contents

Related Research Articles

References

External links

Further reading