ACTL8

ACTL8
Identifiers
Aliases	ACTL8 , CT57, actin like 8
External IDs	HomoloGene: 57127; GeneCards: ACTL8; OMA:ACTL8 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p36.13 Start 17,755,333 bp [1] End 17,827,063 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte testicle gonad right testis left testis mucosa of transverse colon rectum frontal lobe Cortex of frontal lobe n/a More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding cytoskeletal protein-membrane anchor activity Cellular component cytoplasm cytoskeleton centrosome dynactin complex cell cortex region Biological process epithelial cell differentiation establishment of mitotic spindle orientation nuclear migration along microtubule Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 81569 n/a Ensembl ENSG00000117148 n/a UniProt Q9H568 n/a RefSeq (mRNA) NM_030812 n/a RefSeq (protein) NP_110439 n/a Location (UCSC) Chr 1: 17.76 – 17.83 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Actin-like 8 is a protein in humans that is encoded by the ACTL8 gene. It is a protein that is used in making the intracellular architecture of cells. ^[3] ACTL8 expression is significantly upregulated in gastric cancer cells and is strongly associated with negative patient outcomes. ^[4]

References

1. GRCh38: Ensembl release 89: ENSG00000117148 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: Actin-like 8" . Retrieved 2012-11-02.
4. Yu, Wenhao; Zhang, Qi; Ali, Muhammad; Chen, Bangquan; Sun, Qiannan; Wang, Daorong (2024-10). "ACTL8 Promotes the Progression of Gastric Cancer Through PI3K/AKT/mTOR Signaling Pathway". Digestive Diseases and Sciences. 69 (10): 3786–3798. doi:10.1007/s10620-024-08649-6. ISSN   1573-2568. PMC   11489201 . PMID   39322809.{{cite journal}}: Check date values in: |date= (help)

External links

• Human ACTL8 genome location and ACTL8 gene details page in the UCSC Genome Browser .