ADH1C

Last updated
ADH1C
Protein ADH1C PDB 1deh.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ADH1C , ADH3, alcohol dehydrogenase 1C (class I), gamma polypeptide
External IDs OMIM: 103730; MGI: 87921; HomoloGene: 73888; GeneCards: ADH1C; OMA:ADH1C - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000669

NM_007409

RefSeq (protein)

NP_000660

NP_031435

Location (UCSC) Chr 4: 99.34 – 99.35 Mb Chr 3: 137.97 – 138 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Alcohol dehydrogenase 1C is an enzyme that in humans is encoded by the ADH1C gene. [5]

Contents

Function

This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol (beverage alcohol), retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibit high activity for ethanol oxidation and play a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. [6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000248144 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000074207 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Smith M (Mar 1986). "Genetics of Human Alcohol and Aldehyde Dehydrogenases". Advances in Human Genetics 15. Vol. 15. pp. 249–90. doi:10.1007/978-1-4615-8356-1_5. ISBN   978-1-4615-8358-5. PMID   3006456.
  6. "Entrez Gene: ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide".

Further reading