AGPAT9

GPAT3
Identifiers
Aliases	GPAT3 , AGPAT 10, AGPAT8, LPAAT-theta, MAG1, AGPAT9, HMFN0839, AGPAT10, glycerol-3-phosphate acyltransferase 3
External IDs	OMIM: 610958 MGI: 3603816 HomoloGene: 13099 GeneCards: GPAT3
EC number	2.3.1.51
Gene location (Human)
Chr.	Chromosome 4 (human)
End	83,605,875 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	101,046,968 bp
RNA expression pattern
	Top expressed in
	kidney; ; renal cortex; ; duodenum; ; parietal pleura; ; heart; ; jejunal mucosa; ; testicle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity ; acyltransferase activity ; glycerol-3-phosphate O-acyltransferase activity ; 1-acylglycerol-3-phosphate O-acyltransferase activity ; sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity ;
Cellular component	integral component of membrane ; endoplasmic reticulum membrane ; endoplasmic reticulum ; membrane ;
Biological process	phosphatidic acid biosynthetic process ; CDP-diacylglycerol biosynthetic process ; metabolism ; regulation of TOR signaling ; lipid metabolism ; phospholipid biosynthetic process ; triglyceride biosynthetic process ;
	Sources:Amigo / QuickGO
Orthologs
	84803
	231510
	ENSG00000138678
	ENSMUSG00000029314
	Q53EU6
	Q8C0N2
	NM_001256421 ; NM_001256422 ; NM_032717
	NM_172715
	NP_001243350 ; NP_001243351 ; NP_116106
	NP_766303
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 06, 2022

Glycerol-3-phosphate acyltransferase 3 (GPAT-3) is an enzyme that in humans is encoded by the AGPAT9 gene.^[5]^[6]^[7]^[8] GPAT-3 is also known as:

Function

Glycerol-3-phosphate (G3P) acyltransferases (GPAT; EC 2.3.1.15), such as GPAM and GPAT3 (this enzyme), catalyze the initial step of de novo triacylglycerol (TAG) synthesis by converting glycerol-3-phosphate (G3P) to lysophosphatidic acid (LPA).^[6]

Related Research Articles

Lysophosphatidic acid receptor 2 also known as LPA₂ is a protein that in humans is encoded by the LPAR2 gene. LPA₂ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).

In enzymology, a 1-acylglycerol-3-phosphate O-acyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a glycerol-3-phosphate O-acyltransferase is an enzyme that catalyzes the chemical reaction

Lysophosphatidic acid receptor 3 also known as LPA₃ is a protein that in humans is encoded by the LPAR3 gene. LPA₃ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).

Lipid phosphate phosphohydrolase 1 also known as phosphatidic acid phosphatase 2a is an enzyme that in humans is encoded by the PPAP2A gene.

Adipose triglyceride lipase, also known as patatin-like phospholipase domain-containing protein 2 and ATGL, is an enzyme that in humans is encoded by the PNPLA2 gene. ATGL catalyses the first reaction of lipolysis, where triacylglycerols are hydrolysed to diacylglycerols.

1-acyl-sn-glycerol-3-phosphate acyltransferase beta is an enzyme that in humans is encoded by the AGPAT2 gene.

DNA topoisomerase 3-beta-1 is an enzyme that in humans is encoded by the TOP3B gene.

1-acyl-sn-glycerol-3-phosphate acyltransferase alpha is an enzyme that in humans is encoded by the AGPAT1 gene.

Lysophospholipid acyltransferase 5 is an enzyme that in humans is encoded by the LPCAT3 gene. It is homologous to other membrane-bound O-acyltransferases.

Beta-crystallin A4 is a protein that in humans is encoded by the CRYBA4 gene.

Glycerol-3-phosphate acyltransferase 1, mitochondrial is an enzyme that in humans is encoded by the GPAM gene.

Dehydrogenase/reductase SDR family member 2 is an enzyme that in humans is encoded by the DHRS2 gene.

Adenosine kinase is an enzyme that in humans is encoded by the ADK gene.

1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon is an enzyme that in humans is encoded by the AGPAT5 gene.

The human gene AGK encodes the enzyme mitochondrial acylglycerol kinase.

Glycine-N-acyltransferase, also known as GLYAT, is an enzyme which in humans is encoded by the GLYAT gene.

1-acylglycerol-3-phosphate O-acyltransferase ABHD5 is an enzyme that in humans is encoded by the ABHD5 gene.

1-acyl-sn-glycerol-3-phosphate acyltransferase gamma is an enzyme that in humans is encoded by the AGPAT3 gene. The protein encoded by this gene is an acyltransferase that converts lysophosphatidic acid into phosphatidic acid, which is the second step in the de novo phospholipid biosynthetic pathway. The encoded protein may be an integral membrane protein. Two transcript variants encoding the same protein have been found for this gene.

Glycerol-3-phosphate acyltransferase 4 is a protein that in humans is encoded by the GPAT4 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000138678 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029314 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Clark HF, Gurney AL, Abaya E, et al. (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697 . PMID 12975309.
1 2 Cao J, Li JL, Li D, Tobin JF, Gimeno RE (December 2006). "Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis". Proc. Natl. Acad. Sci. U.S.A. 103 (52): 19695–700. doi: 10.1073/pnas.0609140103 . PMC 1702318 . PMID 17170135.
↑ Tang W, Yuan J, Chen X, Gu X, Luo K, Li J, Wan B, Wang Y, Yu L (September 2006). "Identification of a novel human lysophosphatidic acid acyltransferase, LPAAT-theta, which activates mTOR pathway". J. Biochem. Mol. Biol. 39 (5): 626–35. doi: 10.5483/BMBRep.2006.39.5.626 . PMID 17002884.
↑ "Entrez Gene: AGPAT9: 1-acylglycerol-3-phosphate O-acyltransferase 9".

External links

Human GPAT3 genome location and GPAT3 gene details page in the UCSC Genome Browser .

Tang W, Yuan J, Chen X, et al. (2006). "Identification of a novel human lysophosphatidic acid acyltransferase, LPAAT-theta, which activates mTOR pathway". J. Biochem. Mol. Biol. 39 (5): 626–35. doi: 10.5483/BMBRep.2006.39.5.626 . PMID 17002884.
Yamada S, Ohira M, Horie H, et al. (2004). "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas". Oncogene. 23 (35): 5901–11. doi: 10.1038/sj.onc.1207782 . PMID 15221005.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000138678 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029314 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12975309-5] Clark HF, Gurney AL, Abaya E, et al. (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697 . PMID 12975309.

[pmid17170135-6] 1 2 Cao J, Li JL, Li D, Tobin JF, Gimeno RE (December 2006). "Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis". Proc. Natl. Acad. Sci. U.S.A. 103 (52): 19695–700. doi: 10.1073/pnas.0609140103 . PMC 1702318 . PMID 17170135.

[pmid17002884-7] Tang W, Yuan J, Chen X, Gu X, Luo K, Li J, Wan B, Wang Y, Yu L (September 2006). "Identification of a novel human lysophosphatidic acid acyltransferase, LPAAT-theta, which activates mTOR pathway". J. Biochem. Mol. Biol. 39 (5): 626–35. doi: 10.5483/BMBRep.2006.39.5.626 . PMID 17002884.

[entrez-8] "Entrez Gene: AGPAT9: 1-acylglycerol-3-phosphate O-acyltransferase 9".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

AGPAT9

Contents

Function

Related Research Articles

References

External links

Further reading