AH-7614

AH-7614

Identifiers
IUPAC name 4-methyl-N-(9H-xanthen-9-yl)benzenesulfonamide
CAS Number	6326-06-3
PubChem CID	233085
Chemical and physical data
Formula	C20H17NO3S
Molar mass	351.42 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC1=CC=C(C=C1)S(=O)(=O)NC2C3=CC=CC=C3OC4=CC=CC=C24
InChI InChI=1S/C20H17NO3S/c1-14-10-12-15(13-11-14)25(22,23)21-20-16-6-2-4-8-18(16)24-19-9-5-3-7-17(19)20/h2-13,20-21H,1H3 Key:OZCQEUZTOAAWDK-UHFFFAOYSA-N

AH-7614 is an experimental drug which acts as a potent and selective antagonist for the free fatty acid receptor FFAR4 (GPR120), though it has also been described as an inverse agonist or negative allosteric modulator. ^{[1] [2]} Agonists of FFAR4 have antiinflammatory effects and are of interest in the treatment of various conditions including diabetes and obesity, and as a selective FFAR4 antagonist AH-7614 is important for research into the function of this receptor. ^{[3] [4] [5] [6]}

References

1. Watterson KR, Hansen SV, Hudson BD, Alvarez-Curto E, Raihan SZ, Azevedo CM, et al. (June 2017). "Probe-Dependent Negative Allosteric Modulators of the Long-Chain Free Fatty Acid Receptor FFA4". Molecular Pharmacology. 91 (6): 630–641. doi:10.1124/mol.116.107821. PMC   5438128 . PMID   28385906.
2. Alshammari WS, Duncan EM, Vita L, Kenawy M, Dibnah B, Wabitsch M, et al. (July 2025). "Inverse agonism of the FFA4 free fatty acid receptor controls both adipogenesis and mature adipocyte function". Cellular Signalling. 131 111714. doi:10.1016/j.cellsig.2025.111714. PMID   40057149.
3. Senatorov IS, Moniri NH (April 2018). "The role of free-fatty acid receptor-4 (FFA4) in human cancers and cancer cell lines". Biochemical Pharmacology. 150: 170–180. doi:10.1016/j.bcp.2018.02.011. PMC   5866782 . PMID   29452095.
4. Salaga M, Bartoszek A, Binienda A, Krajewska JB, Fabisiak A, Mosińska P, et al. (August 2021). "Activation of Free Fatty Acid Receptor 4 Affects Intestinal Inflammation and Improves Colon Permeability in Mice". Nutrients. 13 (8): 2716. doi: 10.3390/nu13082716 . PMC   8399282 . PMID   34444876.
5. Morishima M, Wang P, Horii K, Horikawa K, Ono K (July 2024). "Eicosapentaenoic Acid Rescues Cav1.2-L-Type Ca²⁺ Channel Decline Caused by Saturated Fatty Acids via Both Free Fatty Acid Receptor 4-Dependent and -Independent Pathways in Cardiomyocytes". International Journal of Molecular Sciences. 25 (14): 7570. doi: 10.3390/ijms25147570 . PMC   11276759 . PMID   39062812.
6. Wang J, Cai L, Liu J, Zhang F, Zhang G, Kang H, et al. (May 2025). "Fish oil reduces intestinal fat absorption by promoting lacteal junction zippering via GPR120-VEGFR3-MLCK pathway". Journal of Advanced Research. doi:10.1016/j.jare.2025.05.026. PMID   40412483.