AHCYL1

AHCYL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3MTG
Identifiers
Aliases	AHCYL1 , DCAL, IRBIT, PPP1R78, PRO0233, XPVKONA, adenosylhomocysteinase like 1
External IDs	OMIM: 607826; MGI: 2385184; HomoloGene: 77353; GeneCards: AHCYL1; OMA:AHCYL1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p13.3 Start 109,984,765 bp [1] End 110,023,742 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3 F2.3|3 46.83 cM Start 107,570,434 bp [2] End 107,603,876 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in external globus pallidus ventral tegmental area superior vestibular nucleus dorsal motor nucleus of vagus nerve pars reticulata internal globus pallidus subthalamic nucleus pars compacta inferior olivary nucleus inferior ganglion of vagus nerve Top expressed in central gray substance of midbrain CA3 field perirhinal cortex anterior horn of spinal cord entorhinal cortex superior colliculus neural layer of retina nucleus of stria terminalis medulla oblongata inferior colliculi More reference expression data BioGPS More reference expression data
Gene ontology Molecular function adenosylhomocysteinase activity protein binding RNA binding identical protein binding Cellular component intracellular membrane-bounded organelle cytosol extracellular exosome membrane endoplasmic reticulum plasma membrane cytoplasm endoplasmic reticulum membrane apical plasma membrane Biological process protein export from nucleus regulation of ion transmembrane transporter activity regulation of anion transport S-adenosylmethionine cycle response to calcium ion mRNA polyadenylation one-carbon metabolic process regulation of cardiac conduction positive regulation of sodium ion transport epithelial fluid transport regulation of mRNA 3'-end processing angiotensin-activated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10768 229709 Ensembl ENSG00000168710 ENSMUSG00000027893 UniProt O43865 Q80SW1 RefSeq (mRNA) NM_001242673 NM_001242674 NM_001242675 NM_001242676 NM_006621 NM_145542 NM_001357110 NM_001357111 NM_001357112 NM_001357113 RefSeq (protein) NP_001229602 NP_001229603 NP_001229604 NP_001229605 NP_006612 NP_663517 NP_001344039 NP_001344040 NP_001344041 NP_001344042 Location (UCSC) Chr 1: 109.98 – 110.02 Mb Chr 3: 107.57 – 107.6 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Putative adenosylhomocysteinase 2 is an enzyme that in humans is encoded by the AHCYL1 gene. ^{[5] [6] [7] [8]}

Interactions

AHCYL1 has been shown to interact with ITPR1. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000168710 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027893 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dekker JW, Budhia S, Angel NZ, Cooper BJ, Clark GJ, Hart DN, Kato M (Mar 2002). "Identification of an S-adenosylhomocysteine hydrolase-like transcript induced during dendritic cell differentiation". Immunogenetics. 53 (12): 993–1001. doi:10.1007/s00251-001-0402-z. PMID   11904675. S2CID   21593928.
6. Cooper BJ, Key B, Carter A, Angel NZ, Hart DN, Kato M (Aug 2006). "Suppression and overexpression of adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) influences zebrafish embryo development: a possible role for AHCYL1 in inositol phospholipid signaling". J Biol Chem. 281 (32): 22471–84. doi: 10.1074/jbc.M602520200 . PMID   16754674.
7. Ando H, Mizutani A, Matsu-ura T, Mikoshiba K (Mar 2003). "IRBIT, a novel inositol 1,4,5-trisphosphate (IP3) receptor-binding protein, is released from the IP3 receptor upon IP3 binding to the receptor". J Biol Chem. 278 (12): 10602–12. doi: 10.1074/jbc.M210119200 . PMID   12525476.
8. "Entrez Gene: AHCYL1 S-adenosylhomocysteine hydrolase-like 1".

External links

• Human AHCYL1 genome location and AHCYL1 gene details page in the UCSC Genome Browser .

Further reading

• Pawlak A, Toussaint C, Lévy I, et al. (1995). "Characterization of a large population of mRNAs from human testis". Genomics. 26 (1): 151–8. doi:10.1016/0888-7543(95)80096-5. PMID   7782076.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Cleaver JE, Afzal V, Feeney L, et al. (1999). "Increased ultraviolet sensitivity and chromosomal instability related to P53 function in the xeroderma pigmentosum variant". Cancer Res. 59 (5): 1102–8. PMID   10070969.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Imabayashi H, Mori T, Gojo S, et al. (2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis". Exp. Cell Res. 288 (1): 35–50. doi:10.1016/S0014-4827(03)00130-7. PMID   12878157.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics. 4 (9): 1240–50. doi: 10.1074/mcp.M500089-MCP200 . PMID   15951569.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.
• Shirakabe K, Priori G, Yamada H, et al. (2006). "IRBIT, an inositol 1,4,5-trisphosphate receptor-binding protein, specifically binds to and activates pancreas-type Na+/HCO3- cotransporter 1 (pNBC1)". Proc. Natl. Acad. Sci. U.S.A. 103 (25): 9542–7. doi: 10.1073/pnas.0602250103 . PMC   1480443 . PMID   16769890.