AHCYL1

AHCYL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3MTG
Identifiers
Aliases	AHCYL1 , DCAL, IRBIT, PPP1R78, PRO0233, XPVKONA, adenosylhomocysteinase like 1
External IDs	OMIM: 607826 MGI: 2385184 HomoloGene: 77353 GeneCards: AHCYL1
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p13.3 Start 109,984,765 bp [1] End 110,023,742 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3 F2.3|3 46.83 cM Start 107,663,118 bp [2] End 107,696,560 bp [2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • adenosylhomocysteinase activity • GO:0001948 protein binding • RNA binding • identical protein binding Cellular component • intracellular membrane-bounded organelle • cytosol • extracellular exosome • membrane • endoplasmic reticulum • cell membrane • cytoplasm • endoplasmic reticulum membrane • apical plasma membrane Biological process • protein export from nucleus • regulation of ion transmembrane transporter activity • regulation of anion transport • S-adenosylmethionine cycle • response to calcium ion • mRNA polyadenylation • one-carbon metabolic process • regulation of cardiac conduction • positive regulation of sodium ion transport • epithelial fluid transport • regulation of mRNA 3'-end processing • angiotensin-activated signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10768	229709
Ensembl	ENSG00000168710	ENSMUSG00000027893
UniProt	O43865	Q80SW1
RefSeq (mRNA)	NM_001242673 NM_001242674 NM_001242675 NM_001242676 NM_006621	NM_145542 NM_001357110 NM_001357111 NM_001357112 NM_001357113
RefSeq (protein)	NP_001229602 NP_001229603 NP_001229604 NP_001229605 NP_006612	NP_663517 NP_001344039 NP_001344040 NP_001344041 NP_001344042
Location (UCSC)	Chr 1: 109.98 – 110.02 Mb	Chr 3: 107.66 – 107.7 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Putative adenosylhomocysteinase 2 is an enzyme that in humans is encoded by the AHCYL1 gene. ^{[5] [6] [7] [8]}

Interactions

AHCYL1 has been shown to interact with ITPR1. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000168710 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027893 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dekker JW, Budhia S, Angel NZ, Cooper BJ, Clark GJ, Hart DN, Kato M (Mar 2002). "Identification of an S-adenosylhomocysteine hydrolase-like transcript induced during dendritic cell differentiation". Immunogenetics. 53 (12): 993–1001. doi:10.1007/s00251-001-0402-z. PMID   11904675. S2CID   21593928.
6. Cooper BJ, Key B, Carter A, Angel NZ, Hart DN, Kato M (Aug 2006). "Suppression and overexpression of adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) influences zebrafish embryo development: a possible role for AHCYL1 in inositol phospholipid signaling". J Biol Chem. 281 (32): 22471–84. doi: 10.1074/jbc.M602520200 . PMID   16754674.
7. Ando H, Mizutani A, Matsu-ura T, Mikoshiba K (Mar 2003). "IRBIT, a novel inositol 1,4,5-trisphosphate (IP3) receptor-binding protein, is released from the IP3 receptor upon IP3 binding to the receptor". J Biol Chem. 278 (12): 10602–12. doi: 10.1074/jbc.M210119200 . PMID   12525476.
8. "Entrez Gene: AHCYL1 S-adenosylhomocysteine hydrolase-like 1".

External links

• Human AHCYL1 genome location and AHCYL1 gene details page in the UCSC Genome Browser .

Further reading

• Pawlak A, Toussaint C, Lévy I, et al. (1995). "Characterization of a large population of mRNAs from human testis". Genomics. 26 (1): 151–8. doi:10.1016/0888-7543(95)80096-5. PMID   7782076.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Cleaver JE, Afzal V, Feeney L, et al. (1999). "Increased ultraviolet sensitivity and chromosomal instability related to P53 function in the xeroderma pigmentosum variant". Cancer Res. 59 (5): 1102–8. PMID   10070969.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Imabayashi H, Mori T, Gojo S, et al. (2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis". Exp. Cell Res. 288 (1): 35–50. doi:10.1016/S0014-4827(03)00130-7. PMID   12878157.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics. 4 (9): 1240–50. doi: 10.1074/mcp.M500089-MCP200 . PMID   15951569.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.
• Shirakabe K, Priori G, Yamada H, et al. (2006). "IRBIT, an inositol 1,4,5-trisphosphate receptor-binding protein, specifically binds to and activates pancreas-type Na+/HCO3- cotransporter 1 (pNBC1)". Proc. Natl. Acad. Sci. U.S.A. 103 (25): 9542–7. doi: 10.1073/pnas.0602250103 . PMC   1480443 . PMID   16769890.