AKAP10

AKAP10
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3IM4, 3TMH
Identifiers
Aliases	AKAP10 , AKAP-10, D-AKAP-2, D-AKAP2, PRKA10, A-kinase anchoring protein 10
External IDs	OMIM: 604694; MGI: 1890218; HomoloGene: 32452; GeneCards: AKAP10; OMA:AKAP10 - orthologs
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	61,821,078 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; Achilles tendon; ; trabecular bone; ; monocyte; ; nipple; ; blood; ; optic nerve; ; bone marrow cells; ; visceral pleura; ; pancreatic ductal cell;
	Top expressed in
	spermatid; ; endocardial cushion; ; zygote; ; secondary oocyte; ; renal corpuscle; ; medullary collecting duct; ; Rostral migratory stream; ; seminiferous tubule; ; spermatocyte; ; primary oocyte;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding ; protein kinase A binding ;
Cellular component	plasma membrane ; membrane ; mitochondrion ; cytoplasm ; cytosol ; protein-containing complex ;
Biological process	blood coagulation ; signal transduction ; protein localization ;
	Sources:Amigo / QuickGO
Orthologs
	11216
	56697
	n/a
	ENSMUSG00000047804
	O43572
	O88845
	NM_007202 ; NM_001330152
	NM_019921
	NP_001317081 ; NP_009133
	NP_064305
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated June 22, 2024

A kinase anchor protein 10, mitochondrial is an enzyme that in humans is encoded by the AKAP10 gene.^[4]^[5]

Function

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein interacts with both the type I and type II regulatory subunits of PKA; therefore, it is a dual-specific AKAP. This protein is highly enriched in mitochondria. It contains RGS (regulator of G protein signalling) domains, in addition to a PKA-RII subunit-binding domain. The mitochondrial localization and the presence of RGS domains may have important implications for the function of this protein in PKA and G protein signal transduction.^[5]

Interactions

AKAP10 has been shown to interact with PDZK1 ^[6] and PRKAR1A.^[4]^[7]

Related Research Articles

<span class="mw-page-title-main">Protein kinase A</span> Family of enzymes

In cell biology, protein kinase A (PKA) is a family of serine-threonine kinase whose activity is dependent on cellular levels of cyclic AMP (cAMP). PKA is also known as cAMP-dependent protein kinase. PKA has several functions in the cell, including regulation of glycogen, sugar, and lipid metabolism. It should not be confused with 5'-AMP-activated protein kinase.

cAMP-dependent protein kinase type I-alpha regulatory subunit is an enzyme that in humans is encoded by the PRKAR1A gene.

cAMP-dependent protein kinase type II-alpha regulatory subunit is an enzyme that in humans is encoded by the PRKAR2A gene.

A-kinase anchor protein 13 is a protein that in humans, is encoded by the AKAP13 gene. This protein is also called AKAP-Lbc because it encodes the lymphocyte blast crisis (Lbc) oncogene, and ARHGEF13/RhoGEF13 because it contains a guanine nucleotide exchange factor (GEF) domain for the RhoA small GTP-binding protein.

cAMP-dependent protein kinase catalytic subunit beta is an enzyme that in humans is encoded by the PRKACB gene.

Regulator of G-protein signaling 19 is a protein that in humans is encoded by the RGS19 gene.

Guanine nucleotide-binding protein subunit beta-5 is a protein that in humans is encoded by the GNB5 gene. Alternatively spliced transcript variants encoding different isoforms exist.

Gamma-aminobutyric acid receptor subunit beta-1 is a protein that in humans is encoded by the GABRB1 gene.

Regulator of G-protein signaling 7 is a protein that in humans is encoded by the RGS7 gene.

A kinase anchor protein 1, mitochondrial is an enzyme that in humans is encoded by the AKAP1 gene.

Adenylyl cyclase type 5 is an enzyme that in humans is encoded by the ADCY5 gene.

A-kinase anchor protein 8 is an enzyme that, in humans, is encoded by the AKAP8 gene.

PAS domain-containing serine/threonine-protein kinase is an enzyme that in humans is encoded by the PASK gene.

Vinexin is a protein that in humans is encoded by the SORBS3 gene.

A-kinase anchor protein 11 is an enzyme that in humans is encoded by the AKAP11 gene.

A-kinase anchor protein 6 is an enzyme that in humans is encoded by the AKAP6 gene.

Regulator of G-protein signalling 9, also known as RGS9, is a human gene, which codes for a protein involved in regulation of signal transduction inside cells. Members of the RGS family, such as RGS9, are signaling proteins that suppress the activity of G proteins by promoting their deactivation.[supplied by OMIM]

Regulator of G-protein signaling 11 is a protein that in humans is encoded by the RGS11 gene.

<span class="mw-page-title-main">AKAP2</span> Protein-coding gene in the species Homo sapiens

A-kinase anchor protein 2 is an enzyme that in humans is encoded by the AKAP2 gene. It is likely involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP. Malfunction of AKAP2 is associated with Kallmann Syndrome.

The A-kinase anchoring proteins or A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. At least 20 AKAPs have been cloned. There are at least 50 members, often named after their molecular mass.

References

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000047804 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Huang LJ, Durick K, Weiner JA, Chun J, Taylor SS (November 1997). "D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain". Proc. Natl. Acad. Sci. U.S.A. 94 (21): 11184–9. Bibcode:1997PNAS...9411184H. doi: 10.1073/pnas.94.21.11184 . PMC 23409 . PMID 9326583.
1 2 "Entrez Gene: AKAP10 A kinase (PRKA) anchor protein 10".
↑ Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H (November 2003). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney Int. 64 (5): 1733–45. doi: 10.1046/j.1523-1755.2003.00266.x . PMID 14531806.
↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

External links

Human AKAP10 genome location and AKAP10 gene details page in the UCSC Genome Browser .

Lester LB, Scott JD (1997). "Anchoring and scaffold proteins for kinases and phosphatases". Recent Prog. Horm. Res. 52: 409–29, discussion 429–30. PMID 9238861.
Michel JJ, Scott JD (2002). "AKAP mediated signal transduction". Annu. Rev. Pharmacol. Toxicol. 42: 235–57. doi:10.1146/annurev.pharmtox.42.083101.135801. PMID 11807172.
Epplen C, Epplen JT (1994). "Expression of (cac)n/(gtg)n simple repetitive sequences in mRNA of human lymphocytes". Hum. Genet. 93 (1): 35–41. doi:10.1007/BF00218910. PMID 7505766. S2CID 22998633.
Wang L, Sunahara RK, Krumins A, Perkins G, Crochiere ML, Mackey M, Bell S, Ellisman MH, Taylor SS (2001). "Cloning and mitochondrial localization of full-length D-AKAP2, a protein kinase A anchoring protein". Proc. Natl. Acad. Sci. U.S.A. 98 (6): 3220–5. Bibcode:2001PNAS...98.3220W. doi: 10.1073/pnas.051633398 . PMC 30634 . PMID 11248059.
Hamuro Y, Burns L, Canaves J, Hoffman R, Taylor S, Woods V (2002). "Domain organization of D-AKAP2 revealed by enhanced deuterium exchange-mass spectrometry (DXMS)". J. Mol. Biol. 321 (4): 703–14. CiteSeerX 10.1.1.477.4850 . doi:10.1016/S0022-2836(02)00419-9. PMID 12206784.
Kammerer S, Burns-Hamuro LL, Ma Y, Hamon SC, Canaves JM, Shi MM, Nelson MR, Sing CF, Cantor CR, Taylor SS, Braun A (2003). "Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism". Proc. Natl. Acad. Sci. U.S.A. 100 (7): 4066–71. Bibcode:2003PNAS..100.4066K. doi: 10.1073/pnas.2628028100 . PMC 153049 . PMID 12646697.
Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H (2003). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney Int. 64 (5): 1733–45. doi: 10.1046/j.1523-1755.2003.00266.x . PMID 14531806.
Burns-Hamuro LL, Barraclough DM, Taylor SS (2004). "Identification and Functional Analysis of Dual-Specific a Kinase-Anchoring Protein-2". Regulators of G-Protein Signaling, Part B. Methods in Enzymology. Vol. 390. Academic Press. pp. 354–74. doi:10.1016/S0076-6879(04)90022-5. ISBN 978-0-12-182795-3. PMID 15488188.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Tingley WG, Pawlikowska L, Zaroff JG, Kim T, Nguyen T, Young SG, Vranizan K, Kwok PY, Whooley MA, Conklin BR (2007). "Gene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulation". Proc. Natl. Acad. Sci. U.S.A. 104 (20): 8461–6. Bibcode:2007PNAS..104.8461T. doi: 10.1073/pnas.0610393104 . PMC 1866184 . PMID 17485678.

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[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000047804 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9326583-4] 1 2 Huang LJ, Durick K, Weiner JA, Chun J, Taylor SS (November 1997). "D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain". Proc. Natl. Acad. Sci. U.S.A. 94 (21): 11184–9. Bibcode:1997PNAS...9411184H. doi: 10.1073/pnas.94.21.11184 . PMC 23409 . PMID 9326583.

[entrez-5] 1 2 "Entrez Gene: AKAP10 A kinase (PRKA) anchor protein 10".

[pmid14531806-6] Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H (November 2003). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney Int. 64 (5): 1733–45. doi: 10.1046/j.1523-1755.2003.00266.x . PMID 14531806.

[pmid16189514-7] Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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