ALG11

ALG11
Identifiers
Aliases	ALG11 , CDG1P, GT8, alpha-1,2-mannosyltransferase, ALG11 alpha-1,2-mannosyltransferase
External IDs	OMIM: 613666; MGI: 2142632; HomoloGene: 68893; GeneCards: ALG11; OMA:ALG11 - orthologs
Gene location (Human) Chr. Chromosome 13 (human) [1] Band 13q14.3 Start 52,012,391 bp [1] End 52,079,232 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8|8 A2 Start 22,550,737 bp [2] End 22,561,643 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans Achilles tendon endometrium epithelium of colon gonad bone marrow cells placenta tonsil corpus callosum testicle Top expressed in spermatocyte genital tubercle hand tail of embryo supraoptic nucleus seminal vesicula superior cervical ganglion medullary collecting duct trigeminal ganglion substantia nigra More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity glycosyltransferase activity GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity Cellular component integral component of membrane endoplasmic reticulum membrane endoplasmic reticulum membrane Biological process mannosylation oligosaccharide-lipid intermediate biosynthetic process protein N-linked glycosylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 440138 207958 Ensembl ENSG00000253710 ENSMUSG00000063362 UniProt Q2TAA5 Q3TZM9 RefSeq (mRNA) NM_001004127 NM_001243161 NM_183142 RefSeq (protein) NP_001004127 NP_001230090 NP_898965 Location (UCSC) Chr 13: 52.01 – 52.08 Mb Chr 8: 22.55 – 22.56 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Asparagine-linked glycosylation protein 11 is an enzyme encoded by the ALG11 gene. ^[5]

See also

• Congenital disorder of glycosylation

^[6]

^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000253710 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000063362 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: asparagine-linked glycosylation 11".
6. Cipollo, JF; Trimble, RB; Chi, JH; Yan, Q; Dean, N (2001). "The yeast ALG11 gene specifies addition of the terminal alpha 1,2-Man to the Man5GlcNAc2-PP-dolichol N-glycosylation intermediate formed on the cytosolic side of the endoplasmic reticulum". J. Biol. Chem. 276 (24): 21828–40. doi: 10.1074/jbc.m010896200 . PMID   11278778.
7. Gao, XD; Nishikawa, A; Dean, N. (Jun 2004). "Physical interactions between the Alg1, Alg2, and Alg11 mannosyltransferases of the endoplasmic reticulum. 2004". Glycobiology. 14 (6): 559–70. CiteSeerX   10.1.1.572.6611 . doi:10.1093/glycob/cwh072. PMID   15044395.

External links

• Human ALG11 genome location and ALG11 gene details page in the UCSC Genome Browser .

Further reading

• Rohozinski J, Lamb DJ, Bishop CE (2006). "UTP14c is a recently acquired retrogene associated with spermatogenesis and fertility in man". Biol. Reprod. 74 (4): 644–51. doi: 10.1095/biolreprod.105.046698 . PMID   16354793.
• Rind N, Schmeiser V, Thiel C, et al. (2010). "A severe human metabolic disease caused by deficiency of the endoplasmatic mannosyltransferase hALG11 leads to congenital disorder of glycosylation-Ip". Hum. Mol. Genet. 19 (8): 1413–24. doi: 10.1093/hmg/ddq016 . PMID   20080937.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
• Cipollo JF, Trimble RB, Chi JH, Yan Q, Dean N (June 2001). "The yeast ALG11 gene specifies addition of the terminal alpha 1,2-Man to the Man5GlcNAc2-PP-dolichol N-glycosylation intermediate formed on the cytosolic side of the endoplasmic reticulum". J. Biol. Chem. 276 (24): 21828–40. doi: 10.1074/jbc.M010896200 . PMID   11278778.