ARHGAP24

ARHGAP24
Identifiers
Aliases	ARHGAP24 , FILGAP, RC-GAP72, RCGAP72, p73, p73RhoGAP, Rho GTPase activating protein 24
External IDs	OMIM: 610586 MGI: 1922647 HomoloGene: 32754 GeneCards: ARHGAP24
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4q21.23-q21.3 Start 85,475,150 bp [1] End 86,002,668 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 E5 Start 102,481,391 bp [2] End 102,897,937 bp [2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity Cellular component • cytoplasm • cytosol • adherens junction • cell junction • cell projection • cytoskeleton • focal adhesion Biological process • multicellular organism development • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • cell differentiation • regulation of small GTPase mediated signal transduction • angiogenesis • signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	83478	231532
Ensembl	ENSG00000138639	ENSMUSG00000057315
UniProt	Q8N264	Q8C4V1
RefSeq (mRNA)	NM_001025616 NM_001042669 NM_001287805 NM_031305 NM_001346093	NM_001286468 NM_029270 NM_146161 NM_001346585
RefSeq (protein)	NP_001020787 NP_001036134 NP_001274734 NP_001333022 NP_112595	NP_001273397 NP_001333514 NP_083546 NP_666273
Location (UCSC)	Chr 4: 85.48 – 86 Mb	Chr 5: 102.48 – 102.9 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Rho GTPase-activating protein 24 is an enzyme that in humans is encoded by the ARHGAP24 gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000138639 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000057315 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–435. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
6. Katoh M, Katoh M (Aug 2004). "Identification and characterization of ARHGAP24 and ARHGAP25 genes in silico". International Journal of Molecular Medicine. 14 (2): 333–8. doi:10.3892/ijmm.14.2.333. PMID   15254788.
7. "Entrez Gene: ARHGAP24 Rho GTPase activating protein 24".

External links

• Human ARHGAP24 genome location and ARHGAP24 gene details page in the UCSC Genome Browser .

Further reading

• Sanger Centre, The; Washington University Genome Sequencing Cente, The (Nov 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–108. doi: 10.1101/gr.8.11.1097 . PMID   9847074.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–292. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Lee SY, Obata Y, Yoshida M, Stockert E, Williamson B, Jungbluth AA, Chen YT, Old LJ, Scanlan MJ (Mar 2003). "Immunomic analysis of human sarcoma". Proceedings of the National Academy of Sciences of the United States of America. 100 (5): 2651–2656. doi: 10.1073/pnas.0437972100 . PMC   151395 . PMID   12601173.
• Su ZJ, Hahn CN, Goodall GJ, Reck NM, Leske AF, Davy A, Kremmidiotis G, Vadas MA, Gamble JR (Aug 2004). "A vascular cell-restricted RhoGAP, p73RhoGAP, is a key regulator of angiogenesis". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12212–12217. doi: 10.1073/pnas.0404631101 . PMC   514459 . PMID   15302923.
• Lavelin I, Geiger B (Feb 2005). "Characterization of a novel GTPase-activating protein associated with focal adhesions and the actin cytoskeleton". The Journal of Biological Chemistry. 280 (8): 7178–7185. doi: 10.1074/jbc.M411990200 . PMID   15611138.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Ohta Y, Hartwig JH, Stossel TP (Aug 2006). "FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling". Nature Cell Biology. 8 (8): 803–814. doi:10.1038/ncb1437. PMID   16862148. S2CID   5754772.