ARHGAP9

Last updated
ARHGAP9
Protein ARHGAP9 PDB 2p0d.png
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases ARHGAP9 , 10C, RGL1, Rho GTPase activating protein 9
External IDs OMIM: 610576 MGI: 2143764 HomoloGene: 13041 GeneCards: ARHGAP9
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001285785
NM_146011
NM_001359656
NM_001359657

RefSeq (protein)

n/a

Location (UCSC) Chr 12: 57.47 – 57.49 Mb Chr 10: 127.16 – 127.17 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Rho GTPase-activating protein 9 is an enzyme that in humans is encoded by the ARHGAP9 gene. [5] [6]

Function

This gene encodes a member of the Rho-GAP family of GTPase activating proteins. The protein has substantial GAP activity towards several Rho-family GTPases in vitro, converting them to an inactive GDP-bound state. It is implicated in regulating adhesion of hematopoietic cells to the extracellular matrix. Multiple transcript variants encoding different isoforms have been found for this gene. [6]

Related Research Articles

<span class="mw-page-title-main">ARHGAP1</span> Protein-coding gene in humans

Rho GTPase-activating protein 1 is an enzyme that in humans is encoded by the ARHGAP1 gene.

<span class="mw-page-title-main">ARHGAP5</span> Protein-coding gene in the species Homo sapiens

Rho GTPase-activating protein 5 is an enzyme that in humans is encoded by the ARHGAP5 gene.

<span class="mw-page-title-main">ARHGAP4</span> Protein-coding gene in humans

Rho GTPase-activating protein 4 is an enzyme that in humans is encoded by the ARHGAP4 gene. It has been shown to regulate cell motility and axonal outgrowth in vitro.

<span class="mw-page-title-main">Rnd2</span> Protein-coding gene in the species Homo sapiens

Rnd2 is a small signaling G protein, and is a member of the Rnd subgroup of the Rho family of GTPases. It is encoded by the gene RND2.

<span class="mw-page-title-main">CDC42EP1</span> Protein-coding gene in the species Homo sapiens

Cdc42 effector protein 1 is a protein that in humans is encoded by the CDC42EP1 gene.

<span class="mw-page-title-main">GEM (gene)</span> Protein-coding gene in humans

GTP-binding protein GEM is a protein that in humans is encoded by the GEM gene.

<span class="mw-page-title-main">RhoH</span> Protein-coding gene in the species Homo sapiens

RhoH is a small signaling G protein, and is a member of the Rac subfamily of the family Rho family of GTPases. It is encoded by the gene RHOH.

<span class="mw-page-title-main">BNIP2</span> Protein-coding gene in the species Homo sapiens

BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 is a protein that in humans is encoded by the BNIP2 gene.

<span class="mw-page-title-main">ARHGAP26</span> Protein-coding gene in the species Homo sapiens

Rho GTPase activating protein 26 (ARHGAP26) also known as GTPase Regulator Associated with Focal Adhesion Kinase (GRAF) is a protein that in humans is encoded by the ARHGAP26 gene.

<span class="mw-page-title-main">ARHGAP24</span> Protein-coding gene in the species Homo sapiens

Rho GTPase-activating protein 24 is an enzyme that in humans is encoded by the ARHGAP24 gene.

<span class="mw-page-title-main">SRGAP3</span> Protein-coding gene in the species Homo sapiens

SLIT-ROBO Rho GTPase-activating protein 3 is an enzyme that in humans is encoded by the SRGAP3 gene.

<span class="mw-page-title-main">ARHGAP8</span> Protein-coding gene in the species Homo sapiens

Rho GTPase-activating protein 8 is a protein that in humans is encoded by the ARHGAP8 gene.

<span class="mw-page-title-main">UBXD5</span> Protein-coding gene in the species Homo sapiens

UBX domain-containing protein 11 is a protein that in humans is encoded by the UBXN11 gene.

<span class="mw-page-title-main">SRGAP1</span> Protein-coding gene in the species Homo sapiens

SLIT-ROBO Rho GTPase-activating protein 1 is an enzyme that in humans is encoded by the SRGAP1 gene.

<span class="mw-page-title-main">CENTD1</span> Protein-coding gene in the species Homo sapiens

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the ARAP2 gene.

<span class="mw-page-title-main">ARHGAP19</span> Protein-coding gene in the species Homo sapiens

Rho GTPase-activating protein 19 is an enzyme that in humans is encoded by the ARHGAP19 gene.

<span class="mw-page-title-main">ARHGAP31</span> Protein-coding gene in the species Homo sapiens

The Rho GTPase activating protein 31 is encoded in humans by the ARHGAP31 gene. It is a Cdc42/Rac1 GTPase regulator.

<span class="mw-page-title-main">ARHGAP25</span> Protein-coding gene in the species Homo sapiens

Rho GTPase activating protein 25 is a protein that in humans is encoded by the ARHGAP25 gene. The gene is also known as KAIA0053. ARHGAP25 belongs to a family of Rho GTPase-modulating proteins that are implicated in actin remodeling, cell polarity, and cell migration.

ARHGAP29 is a gene located on chromosome 1p22 that encodes Rho GTPase activating protein (GAP) 29, a protein that mediates the cyclical regulation of small GTP binding proteins such as RhoA.

<span class="mw-page-title-main">ARHGAP44</span> Protein-coding gene in the species Homo sapiens

Rho GTPase activating protein 44 is a protein in humans that is encoded by the ARHGAP44 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000123329 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040345 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Furukawa Y, Kawasoe T, Daigo Y, Nishiwaki T, Ishiguro H, Takahashi M, Kitayama J, Nakamura Y (Jun 2001). "Isolation of a novel human gene, ARHGAP9, encoding a rho-GTPase activating protein". Biochemical and Biophysical Research Communications. 284 (3): 643–9. doi:10.1006/bbrc.2001.5022. PMID   11396949.
  6. 1 2 "Entrez Gene: ARHGAP9 Rho GTPase activating protein 9".

Further reading