ARHGEF3

Last updated
ARHGEF3
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ARHGEF3 , GEF3, STA3, XPLN, Rho guanine nucleotide exchange factor 3
External IDs MGI: 1918954 HomoloGene: 41329 GeneCards: ARHGEF3
Gene location (Human)
Ideogram human chromosome 3.svg
Chr. Chromosome 3 (human) [1]
Human chromosome 3 ideogram.svg
HSR 1996 II 3.5e.svg
Red rectangle 2x18.png
Band 3p14.3Start56,727,418 bp [1]
End57,079,329 bp [1]
RNA expression pattern
PBB GE ARHGEF3 218501 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

50650

71704

Ensembl

ENSG00000163947

ENSMUSG00000021895

UniProt

Q9NR81

Q91X46

RefSeq (mRNA)

NM_001128615
NM_001128616
NM_001289698
NM_019555

NM_001289686
NM_001289687
NM_001289688
NM_027871

RefSeq (protein)

NP_001122087
NP_001122088
NP_001276627
NP_062455

NP_001276615
NP_001276616
NP_001276617
NP_082147

Location (UCSC) Chr 3: 56.73 – 57.08 Mb Chr 14: 27.11 – 27.4 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Rho guanine nucleotide exchange factor (GEF) 3, also known as ARHGEF3, is a human gene. [5]

Gene basic physical and functional unit of heredity

In biology, a gene is a sequence of nucleotides in DNA or RNA that codes for a molecule that has a function. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic trait. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes as well as gene–environment interactions. Some genetic traits are instantly visible, such as eye color or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that constitute life.

Contents

Function

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. This protein is similar to the NET1A protein. [5]

Interactions

ARHGEF3 has been shown to interact with RHOA [6] and RHOB. [6]

RHOA protein-coding gene in the species Homo sapiens

Ras homolog gene family, member A (RhoA) is a small GTPase protein in the Rho family. While the effects of RhoA activity are not all well known, it is primarily associated with cytoskeleton regulation, mostly actin stress fibers formation and actomyosin contractility. In humans, it is encoded by the gene RHOA. It acts upon several effectors. Among them, ROCK1 and DIAPH1 are the best described. RhoA, and the other Rho GTPases, are part of a larger family of related proteins known as the Ras superfamily, a family of proteins involved in the regulation and timing of cell division. RhoA is one of the oldest Rho GTPases, with homologues present in the genomes since 1.5 billions years. As a consequence, RhoA is somehow involved in many cellular processes which emerged throughout evolution. RhoA specifically is regarded as a prominent regulatory factor in other functions such as the regulation of cytoskeletal dynamics, transcription, cell cycle progression and cell transformation.

RHOB protein-coding gene in the species Homo sapiens

Ras homolog gene family, member B, also known as RHOB, is a protein which in humans is encoded by the RHOB gene.

Related Research Articles

ARHGEF2 protein-coding gene in the species Homo sapiens

Rho guanine nucleotide exchange factor 2 is a protein that in humans is encoded by the ARHGEF2 gene.

ARHGEF12 protein-coding gene in the species Homo sapiens

Rho guanine nucleotide exchange factor 12 is a protein that in humans is encoded by the ARHGEF12 gene.

RAB5B protein-coding gene in the species Homo sapiens

Ras-related protein Rab-5B is a protein that in humans is encoded by the RAB5B gene.

SYT3 protein-coding gene in the species Homo sapiens

Synaptotagmin-3 is a protein that in humans is encoded by the SYT3 gene.

TXLNB protein-coding gene in the species Homo sapiens

Beta-taxilin is a protein that in humans is encoded by the TXLNB gene.

KIAA1267 protein-coding gene in the species Homo sapiens

Uncharacterized protein KIAA1267 is a protein that in humans is encoded by the KIAA1267 gene.

YIPF3 protein-coding gene in the species Homo sapiens

Protein YIPF3 is a protein that in humans is encoded by the YIPF3 gene. Along with YIPF4, it is concentrated in the cis-Golgi region. There the two form a complex and may be involved in the maintenance of the Golgi structure.

ARMC9 protein-coding gene in the species Homo sapiens

LisH domain-containing protein ARMC9 is a protein that in humans is encoded by the ARMC9 gene.

TMEM47 protein-coding gene in the species Homo sapiens

Transmembrane protein 47 is a protein that in humans is encoded by the TMEM47 gene.

HMGB3 protein-coding gene in the species Homo sapiens

High-mobility group protein B3 is a protein that in humans is encoded by the HMGB3 gene.

Hippocalcin-like protein 4 protein-coding gene in the species Homo sapiens

Hippocalcin like 4, also known as HPCAL4, is a human gene.

SYT13 protein-coding gene in the species Homo sapiens

Synaptotagmin-13 is a protein that in humans is encoded by the SYT13 gene.

FARP1 protein-coding gene in the species Homo sapiens

FERM, RhoGEF and pleckstrin domain-containing protein 1 is a protein that in humans is encoded by the FARP1 gene.

STEAP3 protein-coding gene in the species Homo sapiens

Metalloreductase STEAP3 is an enzyme that in humans is encoded by the STEAP3 gene.

ZNF34 protein-coding gene in the species Homo sapiens

Zinc finger protein 34 is a protein that in humans is encoded by the ZNF34 gene.

ARHGEF9 protein-coding gene in the species Homo sapiens

Rho guanine nucleotide exchange factor 9 is a protein that in humans is encoded by the ARHGEF9 gene.

IQCE protein-coding gene in the species Homo sapiens

IQ domain-containing protein E is a protein that in humans is encoded by the IQCE gene.

LMOD3 protein-coding gene in the species Homo sapiens

Leiomodin-3 is a protein that in humans is encoded by the LMOD3 gene.

KIAA1539 protein-coding gene in the species Homo sapiens

Uncharacterized protein KIAA1539 is a protein that in humans is encoded by the KIAA1539 gene.

ARHGEF10 protein-coding gene in the species Homo sapiens

The human ARHGEF10 gene encodes the protein Rho guanine nucleotide exchange factor 10.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000163947 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021895 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 "Entrez Gene: ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3".
  6. 1 2 Arthur WT, Ellerbroek SM, Der CJ, Burridge K, Wennerberg K (Nov 2002). "XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC". J. Biol. Chem. 277 (45): 42964–72. doi:10.1074/jbc.M207401200. PMID   12221096.

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Further reading

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